Hepatoprotective and Reno-protective Effects of Artichoke Leaf Extract and Rosemary Extract against Paracetamol Induced Toxicity in Albino Rats

Fadlalla, Eman Aly Sadeek; Galal, Sahar M.

doi:10.9734/jpri/2020/v32i3230935

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Hepatoprotective activity is amongst the biological activities that is reported for R. officinalis extracts in a model of azathioprine-induced toxicity in rats [15], acetaminopheninduced liver damage [16,17], gentamicin-treated rats [18], hepatic damage induced by hypotermic-ischemia in rats [19] and alcoholic liver disease [20], being assigned to the essential oil composition [21] and to its composition in polyphenols [17][18][19], among which rosmarinic acid is the most representative [16]. Nevertheless, this biological activity is less documented and, to the best of our knowledge, there is no clear evidence on the compounds that are responsible for this activity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hepatoprotective Activity and Oxidative Stress Reduction of Rosmarinus officinalis L. Shoots Tincture in Rats with Experimentally Induced Hepatotoxicity

et al. 2021

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Rosmarinus officinalis L. is a widely known species for its medicinal uses, that is also used as raw material for the food and cosmetic industry. The aim of the present study was to offer a novel perspective on the medicinal product originating from this species and to test its hepatoprotective activity. The tested sample consisted in a tincture obtained from the fresh young shoots. Compounds that are evaluated for this activity are polyphenols and terpenoids, that are identified and quantified by HPLC–UV–MS and GC–MS. Antioxidant activity was assessed in vitro, using the DPPH, FRAP and SO assays. Hepatoprotective activity was tested in rats with experimentally-induced hepatotoxicity. In the chemical composition of the tincture, phenolic diterpenes (carnosic acid, carnosol, rosmanol, rosmadial) and rosmarinic acid were found to be the majority compounds, alongside with 1,8-cineole, camphene, linalool, borneol and terpineol among monoterpenes. In vitro, the tested tincture proved significant antioxidant capacity. Results of the in vivo experiment showed that hepatoprotective activity is based on an antioxidant mechanism. In this way, the present study offers a novel perspective on the medicinal uses of the species, proving significant amounts of polyphenols and terpenes in the composition of the fresh young shoots tincture, that has proved hepatoprotective activity through an antioxidant mechanism.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Hepatoprotective Activity and Oxidative Stress Reduction of Rosmarinus officinalis L. Shoots Tincture in Rats with Experimentally Induced Hepatotoxicity

et al. 2021

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“…In few cases, the diseased process is basically to the liver. Liver damage is always linked with necrosis of cells, rise in lipid peroxidation of tissue, and decrease in the GSH levels of tissues 3 . Along this levels of various biochemical markers in serum like AST, ALT ALP, triglycerides, cholesterol, bilirubin, are elevated.…”

Section: Introductionmentioning

confidence: 99%

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Vakkalagadda¹,

Ravula²,

Parameshwar³

et al. 2021

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The methanolic extract of leaves of C.dicoccum was evaluated for its hepatoprotective activity against paracetamol induced hepatotoxicity since it is reported to cause oxidative stress in the animal thereby altering the enzymatic levels. Fresh leaves were collected, shade dried and extract was prepared by cold maceration followed by drying in a rota-vapour using methanol to obtain MECD as a sticky semi-solid mass. Thirty rats were taken and divided into 5 equal groups where, Group I, II, and III served as Normal Control, Negative control (PCM 3g/kg), and Positive control (Silymarin 200mg/kg) respectively; whereas, Group IV and V served as test groups where the rats were pre-treated orally with MECD 200mg/kg and 400mg/kg respectively for six days before administering PCM. On the 8 th day all groups except Group I was administered with PCM (3g/kg). 48 hours post PCM induction, the animals were anesthetized, blood samples were obtained via retro-orbital sinus plexus and then the rats were sacrificed. The serum was assessed for the evaluation parameters like AST, ALT, ALP, and bilirubin levels. Apart from these; SOD, CAT, and MDA levels were also evaluated and it was concluded that treatment with MECD restored the levels to normal thereby exhibiting hepatoprotective activity. Moreover, histopathological evaluation was carried out to assess the liver for inflammation, infiltration, or necrosis where the MECD treated rats showed promising results.

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Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling Pathway

Cao,

Liu,

Wang

et al. 2024

Pharmacognosy Magazine

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Background Hepatocellular carcinoma (HCC) is the third principal reason for tumor-linked fatalities globally. There is no effective cure for HCC due to rapid progression and poor prognosis. Rosmanol (RM) is a phenolic diterpene antioxidant that exhibits anti-inflammatory and anticancer properties. Purpose This research aims to examine the chemopreventive efficacy of RM on the PI3K/Akt pathway as a potential mechanism for its protective effect against N-diethylnitrosamine (DEN)-induced HCC. Materials and Methods Wistar albino male rats were separated into four sets: normal control (NC); DEN-induced HCC model; DEN+RM (40 mg/kg bw); and RM (40 mg/kg bw) alone. To evaluate the chemopreventive mechanism, we assessed the change in body weight, liver weight, hepatotoxicity markers, antioxidant enzymes, lipid peroxidation, proliferation proteins, cytokines, histopathology, and western blot. Results and Conclusion Our data revealed that RM could reduce the loss of body weight, liver weight, toxicity enzymes, oxidative stress, inflammation, and restructuring of the hepatocellular architecture against DEN-stimulated HCC rats. RM-alone treated rats exhibited comparable activity with NC. Furthermore, RM attenuates PCNA and cyclin-D1 protein expression by the regulation of the PI3K/Akt pathway. The possible chemopreventive activities of RM may be owing to its antioxidative, anti-inflammatory, and antiproliferative effects. Thus, RM may aid as an innovative remedial agent for HCC treatment.

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Hepatoprotective and Reno-protective Effects of Artichoke Leaf Extract and Rosemary Extract against Paracetamol Induced Toxicity in Albino Rats

Cited by 4 publications

References 44 publications

Evaluation of Hepatoprotective Activity and Oxidative Stress Reduction of Rosmarinus officinalis L. Shoots Tincture in Rats with Experimentally Induced Hepatotoxicity

Evaluation of Hepatoprotective Activity and Oxidative Stress Reduction of Rosmarinus officinalis L. Shoots Tincture in Rats with Experimentally Induced Hepatotoxicity

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling Pathway

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