Hepatoprotective, Antioxidant and Cytotoxic Potential of Aloe niebuhriana Latex Extract from Yemen

Moharram, Bushra Abdulkarim; Al‐Doaiss, Amin A.; Al-Mahbashi, Hassan M.; Alkahtani, Muneera; Alfaifi, M. A.; Elbehairi, Serag Eldin I.; Saif-Ali, Riyadh

doi:10.36468/pharmaceutical-sciences.675

Cited by 3 publications

(3 citation statements)

References 22 publications

(31 reference statements)

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“…The present study also found that FT3 or FT4 was decreased in patients with erythrodermic psoriasis, and the proportion of patients with normal TSH was as high as 42.59% [16]. This may be due to diffuse erythema and repeated shedding of scales in erythrodermic psoriasis patients, resulting in the loss of large amounts of water, protein, and other nutrients, causing water and electrolyte disturbances, metabolic abnormalities such as hypoproteinemia, and severe symptoms of systemic wasting.…”

Section: Discussionsupporting

confidence: 69%

Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis

Wang

et al. 2021

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Objective. The aim of this study was to investigate the relationship between different psoriasis types and thyroid dysfunction. Methods. The data of patients diagnosed with psoriasis between January 2013 and October 2018 who underwent thyroid function tests were collected. Free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) were measured. The thyroid function of patients with psoriasis vulgaris, pustular psoriasis, erythrodermic psoriasis, and psoriatic arthritis was evaluated, and the differences in hormone levels and antibodies in the pituitary-thyroid axis with psoriasis type were analyzed. Results. The data of a total of 468 patients were analyzed in this study. The proportion of normal hormone levels was higher among vulgaris patients ( P < 0.001 ), while the erythrodermic patients were more likely to have decreased FT3 or FT4 but normal TSH ( P < 0.001 ). FT3 levels were lower in pustular patients ( P < 0.05 ), FT4 levels were lower in erythrodermic patients ( P < 0.05 ), and TSH levels were higher in patients with psoriatic arthritis ( P < 0.05 ). TPOAb levels were higher than normal in all patients, but there was no significant difference in the levels of TPOAb and TGAb among 4 types of the patients. Conclusion. Psoriasis is related to thyroid dysfunction, especially in patients with atypical psoriasis types. The possibility of complications should be considered in erythrodermic patients.

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Section: Discussionsupporting

confidence: 69%

Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis

Wang

et al. 2021

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“…These results were in agreement with other study that reported weak cytotoxicity of other Aloe species. Moharram et al [18] reported that Aloe niebuhriana latex extract exhibited a weak cytotoxicity effect against MCF-7, HepG2 and HCT-116 cancer cell line. Fox et al [19] also reported that Aloe vera, Aloe ferox and Aloe marlothii exhibited weak cytotoxicity effect towards the HaCaT cells using MTT assay.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Activity of Ethanolic Extract of Aloe saudiarabica and Aloe shadensis against Three Human Cancer Cell Line

Algarni¹

2021

JPRI

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Aloe saudiarabica and Aloe shadensis are a rare species of the genus Aloe found only in Saudi Arabia. The cytotoxic activity of both plants were evaluated in the current study using three different human cancer cell line, lung carcinoma (A-549), breast adenocarcinoma (MCF-7) and liver cancer (HepG2), assessed by WST-1 cell viability assays. The results indicate that the Aloe saudiarabica and Aloe shadensis showed weak cytotoxic effects against all three tested cancer cell lines, with an IC50 value of >300 μg/ml. In addition, HepG2 cells were more sensitive to Aloe saudiarabica treatment than MCF-7 and A549 cells, while MCF-7 cells were more sensitive to Aloe shadensis treatment than HepG2 and A549 cells. This study also identified the characteristic chemical constituents of the two plants using gas chromatography-mass spectrometry technique and the result indicated that 9-octadecenoic acid (Z)-, methyl ester (32.23%) was the main compound of Aloe saudiarabica while methyl 9-octadecenoate (17.28%) was the main compound of Aloe shadensis. In conclusion, the in vitro evaluation of Aloe saudiarabica and Aloe shadensis methanolic extraction showed low cytotoxicity on the viability of A-549, MCF-7 and HepG2 cell lines.

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“…Aloe niebuhriana showed weak cytotoxic activity towards MCF-7, human liver cancer HepG2 and HCT-116 cell lines. However, studies of other Aloe species have shown a similar cytotoxic effect towards normal human keratinocytes ( Moharram et al., 2020 ). Hence, this cytotoxic effect may not be restricted to cancer cells.…”

Section: Anticancer Properties Of Latex-bearing Plant Extractsmentioning

confidence: 94%

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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Hepatoprotective, Antioxidant and Cytotoxic Potential of Aloe niebuhriana Latex Extract from Yemen

Cited by 3 publications

References 22 publications

Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis

Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis

Cytotoxic Activity of Ethanolic Extract of Aloe saudiarabica and Aloe shadensis against Three Human Cancer Cell Line

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

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