Hepatoprotective effect of Apocynum venetum L extract on fatty liver disease of 2K1C rats with high-fat and refined-carbohydrate diet

Yang, Xiaoling; Wu, Xiangqi; Jie-ren, Yang; Huang, Zheng-Ming; Chen, Hongyan; Cao, Wenjun; Gen, Miao; Wang, Jianhua; Wen, Hang-Yuan

doi:10.11569/wcjd.v17.i2.135

Cited by 3 publications

(7 citation statements)

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“…Although Apocynum venetum showed no apparent inhibition of TNF-␣ production, it exhibited a potential inhibitory effect against TNF-␣-induced cell death (Xiong et al, 2000). In addition, Apocynum venetum extract (100 and 200 mg/kg/day for 8 weeks) showed protective effects in rats with fatty liver disease and metabolic syndrome, comparable to those treated with captopril (30 mg/kg/day for 8 weeks) (Yang et al, 2009).…”

Section: Hepatoprotective Effectmentioning

confidence: 97%

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Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review

Xie

Zhang

Wang

et al. 2012

Journal of Ethnopharmacology

130

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Section: Hepatoprotective Effectmentioning

confidence: 97%

“…The available literature suggests that there are likely multiple potent mechanisms, such as antihypertensive effect and amelioration of insulin allergy (Yang et al, 2009), that are responsible for the hepatoprotective effects of Apocynum venetum. Further investigations are needed to fully elucidate the exact mechanisms.…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review

Xie

Zhang

Wang

et al. 2012

Journal of Ethnopharmacology

130

View full text Add to dashboard Cite

“…Previous studies demonstrated that A. venetum could prevent xenobiotic compounds induced liver injury as well as fatty liver disease. It has been considered that the anti-oxidant properties of A. venetum were responsible for its hepatoprotective effects (Xiong et al, 2000;Yang et al, 2009). In our present study, pretreatment with ALE significantly improved the survival rates of mice that were intoxicated with a lethal dose of APAP (500 mg/mL), as well as attenuated APAP overdose (300 mg/mL) induced the increase of serum aminotransferase and hepatic histopathological lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Yang et al (2009) demonstrated that ALE has protective effect agianst fatty liver disease of rats with metabolic syndrome. The potent anti-oxidant and radical scavenging activities of flavonoids present in ALE were considered to play a major role in preventing liver disease (Xiong et al, 2000;Yang et al, 2009), however, active constituents of ALE and the underlying mechanisms remain to be fully established. Hence, the present study was aimed to investigate the effect of ALE on liver injury induced by APAP overdose and to explore its possible mechanism.…”

Section: Introductionmentioning

confidence: 97%

“…A. venetum leaf extract (ALE) has also been proven for its protective effect against chemicals-induced toxicity including carbon tetrachloride, D-galactosamine/lipopolysaccharide and D-galactosamine/TNF--induced liver injury (Xiong et al, 2000). Yang et al (2009) demonstrated that ALE has protective effect agianst fatty liver disease of rats with metabolic syndrome. The potent anti-oxidant and radical scavenging activities of flavonoids present in ALE were considered to play a major role in preventing liver disease (Xiong et al, 2000;Yang et al, 2009), however, active constituents of ALE and the underlying mechanisms remain to be fully established.…”

Section: Introductionmentioning

confidence: 99%

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Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice

et al. 2015

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Apocynum venetum L. (A. venetum) has long been used in oriental folk medicine for the treatment of some liver diseases; however, the underlying mechanisms remain to be fully elucidated. Acetaminophen (APAP) is a widely used analgesic drug that can cause acute liver injury in overdose situations. In this study, we investigated the potential protective effect of A. venetum leaf extract (ALE) against APAP-induced hepatotoxicity. Mice were intragastrically administered with ALE once daily for 3 consecutive days prior to receiving a single intraperitoneal injection of APAP. The APAP group showed severe liver injury characterized by the noticeable fluctuations in the following parameters: serum aminotransferases; hepatic malondialdehyde (MDA), 3-nitrotyrosine (3-NT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione (GSH). These liver damages induced by APAP were significantly attenuated by ALE pretreatments. A collective analysis of histopathological examination, DNA laddering and western blot for caspase-3 and cytochrome c indicated that the ALE is also capable of preventing APAP-induced hepatocyte death. Hyperoside, isoquercitrin and their derivatives have been identified as the major components of ALE using HPLC-MS/MS. Taken together, the A. venetum possesses hepatoprotective effects partially due to its anti-oxidant action.

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The chloroplast genome sequence and phylogenetic analysis of Apocynum venetum L.

et al. 2022

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Apocynum venetum L. (Apocynaceae) is valuable for its medicinal compounds and fiber content. Native A. venetum populations are threatened and require protection. Wild A. venetum resources are limited relative to market demand and a poor understanding of the composition of A. venetum at the molecular level. The chloroplast genome contains genetic markers for phylogenetic analysis, genetic diversity evaluation, and molecular identification. In this study, the entire genome of the A. venetum chloroplast was sequenced and analyzed. The A. venetum cp genome is 150,878 bp, with a pair of inverted repeat regions (IRA and IRB). Each inverted repeat region is 25,810 bp, which consist of large (LSC, 81,951 bp) and small (SSC, 17,307 bp) single copy areas. The genome-wide GC content was 38.35%, LSC made up 36.49%, SSC made up 32.41%, and IR made up 43.3%. The A. venetum chloroplast genome encodes 131 genes, including 86 protein-coding genes, eight ribosomal RNA genes, and 37 transfer RNA genes. This study identified the unique characteristics of the A. venetum chloroplast genome, which will help formulate effective conservation and management strategies as well as molecular identification approaches for this important medicinal plant.

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Hepatoprotective effect of Apocynum venetum L extract on fatty liver disease of 2K1C rats with high-fat and refined-carbohydrate diet

Cited by 3 publications

References 0 publications

Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review

Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review

Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice

The chloroplast genome sequence and phylogenetic analysis of Apocynum venetum L.

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