Hepatoprotective effect of aqeous methanolic extract of &lt;i&gt;Rumex dentatus&lt;/i&gt; in paracetamol induced hepatotoxicity in mice

Saleem, Mohammad; Ahmed, Bilal; Karim, Mahrukh; Ahmed, Sibtain; Ahmad, Muhammad Ijaz; Qadir, Muhammad Imran; Syed, Nawazish-i-Husain

doi:10.3329/bjp.v9i3.18874

Cited by 24 publications

(20 citation statements)

References 39 publications

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“…The current data indicated that treatment of HCC group with R. vesicarius extract elicited significant reduction in serum AST, ALT, ALP and γ-GT activity relative to the untreated HCC group. These results are in agreement with Chen (2010) and Saleem et al (2014) who reported that R. dentatus significantly controlled the elevation of liver enzymes. This hepatoprotective action is possibly ascribed to the presence of many active constituents.…”

Section: Discussionsupporting

confidence: 93%

“…Photomicrograph of liver tissue section of HCC group treated with R. vesicarius extract showed very few inflammatory cells infiltration in the hepatic parenchyma. In accordance of our results Saleem et al (2014) reported that animals treated with aqueous methanolic extract of R. dentatus showed almost normal hepatocytes and normal structural organization of the liver.…”

Section: Discussionsupporting

confidence: 93%

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Significance of Rumex Vesicarius as Anticancer Remedy Against Hepatocellular Carcinoma: a Proposal-Based on Experimental Animal Studies

Shahat¹,

Alsaid²,

Kotob³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Rumex vesicarius is an edible herb distributed in Egypt and Saudi Arabia. The whole plant has significant value in folk medicine and it has been used to alleviate several diseases. Hepatocellular carcinoma (HCC), the major primary malignant tumor of the liver, is one of the most life-threatening human cancers. The goal of the current study was to explore the potent role of Rumex vesicarius extract against HCC induced in rats. Thirty adult male albino rats were divided into 3 groups: (I): Healthy animals received orally 0.9 % normal saline and served as negative control group, (II): HCC group in which rats were orally administered N-nitrosodiethylamine NDEA, (III): HCC group treated orally with R. vesicarius extract in a dose of 400 mg/kg b.wt daily for two months. ALT and AST, ALP and γ-GT activities were estimated. CEA, AFP, AFU, GPC-3, Gp-73 and VEGF levels were quantified. Histopathological examination of liver tissue sections was also carried out. The results of the current study showed that the treatment of the HCC group with R. vesicarius extract reversed the significant increase in liver enzymes activity, CEA, AFP, AFU, glypican 3, golgi 73 and VEGF levels in serum as compared to HCC-untreated counterparts. In addition, the favorable impact of R. vesicarius treatment was evidenced by the marked improvement in the histopathological features of the liver of the treated group. In conclusion, the present experimental setting provided evidence for the significance of R. vesicarius as anticancer candidate with a promising anticancer potential against HCC. The powerful hepatoprotective properties, the potent antiangiogenic activity and the effective antiproliferative capacity are responsible for the anticancer effect of this plant.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Significance of Rumex Vesicarius as Anticancer Remedy Against Hepatocellular Carcinoma: a Proposal-Based on Experimental Animal Studies

Shahat¹,

Alsaid²,

Kotob³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Moreover, various important bioactive compounds, such as chlorogenic acid, quercetin, myricitin, vitamin C, and kaempferol, have been identified in these roots. Saleem et al (2014) demonstrated hepatoprotective effect of R. dentatus against paracetamol-induced liver damage in mice. Given the medicinal importance of R. dentatus , the purpose of the present study was to investigate it for possible anticancer activity, using the MDA-MB-231 breast cancer cell line.…”

Section: Introductionmentioning

confidence: 93%

Rumex dentatus Inhibits Cell Proliferation, Arrests Cell Cycle, and Induces Apoptosis in MDA-MB-231 Cells through Suppression of the NF-κB Pathway

et al. 2017

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Background: Rumex dentatus, commonly known as tooth docked, is widely used in traditional system of medicines. Although it is well reported for its biological activities and medicinal value, only few studies have been carried out to assess its anticancer potential.Purpose: This study seeks to evaluate the anticancer activity of leaf extracts of R. dentatus against breast cancer MDA-MB-231 cell line, a triple negative human breast cancer cell line with invasive properties and to identify the molecular targets underlying its mechanism of action.Methods: Cytotoxicity of plant extracts was determined against breast cancer cells, using the MTT assay. Flow cytometry was performed to analyze the changes in cell cycle and apoptotic effect, if any. Cells were also studied for their wound healing and invasive potential as well as for Western blotting of apoptotic genes and nuclear factor-kappaB (NF-κB) pathway.Results: The results revealed that R. dentatus methanol (RM) and chloroform (RC) extracts of R. dentatus had the highest inhibition of cell proliferation in a concentration- and time-dependent manner. This inhibitory effect was found to be linked to arrest of cell cycle at the G0/G1 phase, along with induction of apoptosis and accumulation in the sub-G1 phase. Moreover, it was shown that both RM and RC inhibited the proliferation of the malignant cells and induced apoptosis by repressing the activation of NF-κB and its subsequent transcripts, Bcl-xl, Bcl-2, Cyclin D1, survivin, and XIAP. Apoptosis was also confirmed in the cells as suggested by caspase-3 detection. RM and RC also abrogated IκBa phosphorylation in the malignant cells as well as reduced the invasive and migratory capabilities of these cells.Conclusion: Our findings suggest that the methanol and chloroform extracts of R. dentatus may have anti-cancer compounds that are potentially useful in the treatment of human breast cancer.

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“…The aerial and roots parts of different plants belong to the Polygonaceae family, including Rumex , have been used as a natural source of traditional medicines in several therapeutic uses, such as anti-inflammatory, antioxidants, antianalgesic, and antimicrobial activities [ 10 , 11 ]. They are also used for the treatment of certain diseases like cancer, tumor, and diseases related to liver and urinary/kidney functions [ 12 , 13 ]. There are some reports in the literature about the evaluation of some species of Rumex which have exhibited health-promoting effects and have been used as traditional foods and herbal remedy.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L.

Saoudi

Bouajila

Rahmani

et al. 2021

International Journal of Analytical Chemistry

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Rumex crispus L. (R. crispus) is regarded as an aromatic plant. It was used for its excellent biological properties in traditional medicine. The aerial part was extracted successively by maceration with three solvents increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) to evaluate their chemical compositions and biological activities. The extracts were rich in phenolic compounds (13.0 to 249.8 mg GAE/g of dry weight (dw)). The MeOH extract has presented remarkable IC50 = 6.2 μg/mL for anti-DPPH and 31.6 μg/mL for anti-AChE. However, the DCM extract has the highest cytotoxic activity against the two cancer cells (HCT-116 and MCF-7) (69.2 and 77.2% inhibition at 50 μg/mL, respectively). Interestingly, GC-MS analysis enabled to identify three new compounds in R. crispus extracts, such as L-(−)-arabitol (5), D-(−) fructopyranose (7) detected only in MeOH extract, and 2, 5-dihydroxyacetophenone (3) detected in all extracts. For HPLC chromatograms, cardamonin (8), 5-hydroxy-3′-methoxyflavone (17), and 3′-hydroxy-b-naphthoflavone (18) showed the highest concentrations of 74.0, 55.5, and 50.4 mg/g of dw, respectively, among others who are identified. Some phenolic compounds were identified and quantified by HPLC in more than one organic extract, such as 4′, 5-dihydroxy-7-methoxyflavone (13), 4′, 5-dihydroxy-7-methoxyflavone (14), 5-hydroxy-3′-methoxyflavone (17), and 3′-hydroxy-b-naphthoflavone (18), were found for the first time in the R. crispus extracts. Our results showed that the biological activities of this plant might be linked to their phenolic compounds and that the polar extracts could be considered as new natural supplements to be used in food and pharmaceuticals.

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Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

Cited by 24 publications

References 39 publications

Significance of Rumex Vesicarius as Anticancer Remedy Against Hepatocellular Carcinoma: a Proposal-Based on Experimental Animal Studies

Significance of Rumex Vesicarius as Anticancer Remedy Against Hepatocellular Carcinoma: a Proposal-Based on Experimental Animal Studies

Rumex dentatus Inhibits Cell Proliferation, Arrests Cell Cycle, and Induces Apoptosis in MDA-MB-231 Cells through Suppression of the NF-κB Pathway

Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L.

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