Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

Abstract

Background: In absence of reliable hepatoprotective drug in modern medicine, the traditional herbal medicines have been emphasized. Present study was designed to assess hepatoprotective effect of aqueous extract of Melothria perpusilla (AEMP) against carbon tetrachloride (CCl4) induced liver injury.Methods: Five groups of animals with 6 rats in each were treated for 7 days. Group I received 1% gum acacia in distilled water (1 ml/200 g p.o.) daily. Group II, III, IV and V received CCl4 in liquid paraffin (1 ml/kg s.c.) on day 2, 4 and 6. Group III, IV and V were treated respectively with silymarin (100 mg/kg p.o.), AEMP- 200 and 400 mg/kg p.o. daily. On day 8, liver injury was assessed by measuring serum ALT, AST, ALP and bilirubin.Results: ALT, AST, ALP and bilirubin were significantly reduced in groups receiving both CCl4 and AEMP when compared with CCl4 treated group.Conclusions: AEMP produced hepatoprotective effect against CCl4 induced liver injury.

Amino acid profiles and anti-nutritional contents of traditionally consumed six wild vegetables

“…Singh et al 6 recently conducted an in vivo model study in albino rats with ethyl acetate extract of Melothria perpusilla and reported a significant reduction of intestinal glucose absorption. Similarly, aqueous extract of Melothria perpusilla was studied by Yengkhom et al 7 and they reported hepatoprotective property against CCl4 induced liver injury in the albino rats. This plant also possesses antioxidant and antimicrobial properties.…”

Traditional Medicinal Plant Melothria Perpusilla L. (Cucurbitaceae): Their Botanical, Phytochemical and Pharmacological Overview

“…The advantage of these technologies leads to high volume are therefore the subject of much research for applications in medicine, especially in cancer treatment [13,14]. In Manipur, India the traditional medicine practitioners use specific plants for treatment of different disorders in the form of fresh preparation, decoction and powder of the whole or parts of the plant [15]. A number of compounds of this group have been investigated for their cytotoxic, hepatoprotective, antiinflammatory and cardiovascular effects [34].…”