Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Abstract

Objective:To study the effect of Quinoa seed on carbon tetrachloride (CCL 4 )-induced liver toxicity in Swiss albino male mice. Methods:Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl 4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl 4 -treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted. Results:The results showed that the treatment with Quinoa seed powder significantly reduced CCl 4 -induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies. Conclusion:Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl 4 -induced liver damage in Swiss albino male mice.

Influence of Feeding Quinoa (Chenopodium quinoa) Seeds and Prickly Pear Fruit (Opuntia ficus indica) Peel on the Immune Response and Resistance to Aeromonas sobria Infection in Nile Tilapia (Oreochromis niloticus)

“…Supplementation with QU seed and PP peel at the level of 20% in the diet of the fish challenged with A. sobria showed a significant modulation in the activities of the enzymes AST, ALT, and ALP. This finding agrees with Saxena et al [86], who reported that treatment with QU seed powder significantly reduced the activities of CCl4-induced hepatic enzymes in Swiss albino mice (Mus musculus). Moreover, pretreatment with PP extract significantly reduced the levels of serum hepatic enzymes elevated upon lithium exposure in Wistar rats (Rattus norvegicus) [16].…”

Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of Chenopodium quinoa Sprouts against CCl4-Induced Oxidative Stress in Rats

“…These results are consistent with Halaby et al [ 55 ] who indicated the attenuation effect of quinoa seeds on ALT (30%) and AST (40%) enzymes in rats with induced hypercholesterolemia. Similarly, Saxena et al [ 56 ] confirmed the effects of quinoa extracts on elevated serum ALT and AST enzymes in rats against CCl4-induced oxidative stress. The TBILI indicates the liver injury and CCl 4 had a significantly higher level than NR and treated groups (Si-Vit E, RQS, and YEQ).…”

Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-β1 Pathway

“…A previous study indicated quinoa seed ( Chenopodium quinoa) showed a hepatoprotective effect against CCl 4 -induced liver damage. Chenopodium quinoa seed lowered CCl 4 -induced AST and ALT activities and liver damage by raising SOD and GSH levels [ 15 ]. However, the mechanisms associated with the protection against CCl 4 -induced inflammation and fibrosis were still unclear.…”