Hepatoprotective effect of Cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats

Abstract

Cinnamon is used to flavor most foods in Arabian countries. The aim of this study was to evaluate the medicinal importance, reflecting an important trend in research. The hepatoprotective activity of aqueous and ethanolic extracts of cinnamon was investigated against carbon tetrachloride (CCl 4 ) induced lipid peroxidation and hepatic injury in rats. The elevated serum AST and ALT enzymatic activities induced by CCl 4 were significantly restored to near normal by oral administration of 200 mg/kg of either extracts once daily for 7 days, as compared to untreated rats. There was a significant elevation in the level of liver malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in CCl 4 intoxicated rats. The results obtained indicated that ethanolic extract has more potent hepatoprotective action than water extract against CCl 4 by lowering the MDA level and elevating antioxidants enzymes activities (SOD and CAT). The possible mechanism of this activity may be free radical-scavenging polyphenol compounds. The hepatoprotective properties were documented by the histopathological data obtained. Consequently, this extract can be used as a therapeutic regime in treatment of some hepatic disorders without any side effects. Further study will be done for separation and identification of active components and for testing antitumor activity.

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

“…Studies have shown that antioxidants and plant extracts can play a protective role in inhibiting pesticide-induced toxicity (65,66) . Our results were in agreement with Moselhy et al (21,58) and Mohamed et al (54) in their study of protective effect of myoporum laetum against oxidative stress induced by profenofos in rats. Results are expressed as mean ± SD for four samples **: Significance at P< 0.02 ***: Significance at P< 0.01…”

“…The elevated of serum cholesterol and triglycerides were significantly reduced in the animal groups treated with cinnamon extract (Table 9). These results were in agreement with Moselhy and Ali (21) in the study of protective effect of cinnamon on CCl 4 intoxicated rats. …”

“…Co-administration of water extract of cinnamon to profenofos treated rats (group 4) daily for 30 days along with profenofos residues greatly prevented the deviation in the liver function indices in relation to profenofos residues treated rats (group 3). The reduction of AST and ALT activities by the cinnamon extract is an indication of repair of hepatic tissue damage induced by profenofos residues; our results are in agreement with those obtained by administration of water extract of cinnamon to intoxicated animals with CCl4 induced suppression of increased ALT and AST activities in rats and frogs (21,58) . Thus, administration aqueous extracts of cinnamon revealed hepatoprotective activity against the toxic effect of profenofos.…”

“…Intake of 3g or 6g of cinnamon bark reduced serum glucose in people with type 2 diabetes (20) . Cinnamon extracts have also demonstrated hepatoprotective and antioxidant effects in CCL4-intoxicated rats (21) .…”

Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo

“…Various reports have demonstrated that oxidative stress plays a vital role in liver toxicity induced by such substances as alcohol, carbon tetrachloride, chemotherapeutic agents, and acetaminophen (dos Santos et al, 2007;Kostopanagiotou et al, 2009;Moselhy and Ali, 2009;Samuhasaneeto et al, 2009). Reactive oxygen species (ROS), generated during oxidative stress, are extremely reactive and may modify and inactivate cellular lipids, proteins, DNA, and RNA, and thus cause cell damage.…”