Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2–NFκB pathways

Iqbal, Neelum; Zubair, Hafiz Muhammad; Almutairi, Mikhlid H.; Abbas, Muhammad; Akhtar, Muhammad Furqan; Aleya, Lotfi; Kamel, M Abd El-Nabi; Saleem, Ammara; Jabeen, Qaiser; Noreen, Sobia; Abdel‐Daim, Mohamed M.

doi:10.1016/j.biopha.2022.113840

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…The potential hepatopreventive effect of may be attributed to its richness in phenolic compounds, especially flavonoids. Flavonoid-rich plants are well documented to exhibit hepatoprotective effects by inhibiting key enzymes involved in inflammatory processes, such as PARP-1, TNF-α, and IL-6 ( Iqbal et al, 2022 ; Huang and kraus, 2023 ). Taking account of the pivotal implication of inflammation in hepatic injury prompted by CCl 4 , ROS are not only the source of liver damage, they initiated inflammation by releasing proinflammatory cytokines from activated macrophages ( Lin et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

“…Taking account of the pivotal implication of inflammation in hepatic injury prompted by CCl 4 , ROS are not only the source of liver damage, they initiated inflammation by releasing proinflammatory cytokines from activated macrophages ( Lin et al, 2012 ). CCl 4 activates Kupffer cells to release TNF-α which stimulates the release of IL-1β, and IL-6 that eventually cause hepatic necrosis and alter plasmatic biomarkers ( Iqbal et al, 2022 ; Lu et al, 2015 ). Besides oxidative stress triggers the expression of NF-κB expediting the synthesis of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

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Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

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In this current study, we explored the preventive capacity of the aqueous extract of Orobanche foetida (OF), a root holoparasite, against CCl4 prompt hepatotoxicity in rats. LC-MS/MS profiling revealed the existence of 32 compounds belonging to organic acids, benzoic acid derivatives, and hydroxycinnamic acids along with their glycosides and derivatives as well as several flavonoids. In vitro, OF demonstrated substantial antioxidant potential at DPPH and ABTS assays. Results showed that the pretreatment with OF for 6 weeks at the doses (25 mg/kg bw) and (50 mg/kg bw) countered the CCl4-induced liver injury by restoring liver injuries indicators (ALT, AST, LDH, ALP, GGT and bilirubin), normalizing lipid profile (TC, TG, LDL-C, and HDL-C), as well as, impeding DNA fragmentation. Furthermore, OF blocked the hepatic oxidative stress spurred by CCl4 administration through boosting antioxidant enzymes (GSH, CAT, and SOD) responsible of diminishing lipid peroxidation. exhibited an anti-inflammatory effect by downregulating TNF-α and IL-6 levels. OF suppressive effect on proinflammatory cytokines is further exerted by its capacity to modulate the expression of the NF-κB gene. In silico investigation revealed that among the 32 identified compounds, vanillic acid glucoside and dihydroxybenzoic acid glucoside have strong and stable bindings with the active sites of three key inflammatory proteins (PARP-1, TNF-α, IL-6), which could highlight the antioxidant and anti-inflammatory capacity of. Overall, this research provides a preliminary pharmacological support for the medicinal applications of Orobanche foetida for addressing inflammatory and hepato-pathological conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

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“…Phytochemicals can interfere with many targets, including NF-kB pathways [ 12 , 13 , 14 , 15 ]. Thus, they can be related to regulating many other processes and cascades of inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

et al. 2023

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Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative colitis (UC) and Crohn’s disease (CD). IBD can be associated with the activation of nuclear factors, such as nuclear factor-kB (NF-kB), leading to increased transcription of pro-inflammatory mediators that result in diarrhea, abdominal pain, bleeding, and many extra-intestinal manifestations. Phytochemicals can interfere with many inflammation targets, including NF-κB pathways. Thus, this review aimed to investigate the effects of different phytochemicals in the NF-KB pathways in vitro and in vivo models of IBD. Fifty-six phytochemicals were included in this study, such as curcumin, resveratrol, kaempferol, sesamol, pinocembrin, astragalin, oxyberberine, berberine hydrochloride, botulin, taxifolin, naringin, thymol, isobavachalcone, lancemaside A, aesculin, tetrandrine, Ginsenoside Rk3, mangiferin, diosgenin, theanine, tryptanthrin, lycopene, gyngerol, alantolactone, mangostin, ophiopogonin D, fisetin, sinomenine, piperine, oxymatrine, euphol, artesunate, galangin, and nobiletin. The main observed effects related to NF-kB pathways were reductions in tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, interferon-gamma (IFN-γ), and cyclooxygenase-2 (COX-2), and augmented occludin, claudin-1, zonula occludens-1, and IL-10 expression levels. Moreover, phytochemicals can improve weight loss, stool consistency, and rectal bleeding in IBD. Therefore, phytochemicals can constitute a powerful treatment option for IBD in humans.

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Anti‐inflammatory and anti‐hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis‐associated visceral pain

Libero,

Lucarini,

Recinella

et al. 2024

Phytotherapy Research

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Inflammatory bowel disease (IBD) is a morbid condition characterized by relapsing–remitting inflammation of the colon, accompanied by persistent gut dysmotility and abdominal pain. Different reports demonstrated biological activities of aged black garlic (ABG), including anti‐inflammatory and antioxidant effects. We aimed to investigate beneficial effects exerted by ABGE on colon inflammation by using ex vivo and in vivo experimental models. We investigated the anti‐inflammatory effects of an ABG water extract (ABGE) on rat colon specimens exposed to E. coli lipopolysaccharide (LPS), a known ex vivo experimental model of ulcerative colitis. We determined gene expression of various biomarkers involved in inflammation, including interleukin (IL)‐1β, IL‐6, nuclear factor‐kB (NF‐kB), tumor necrosis factor (TNF)‐α. Moreover, we studied the acute effects of ABGE on visceral pain associated with colitis induced by 2,4‐di‐nitrobenzene sulfonic acid (DNBS) injection in rats. ABGE suppressed LPS‐induced gene expression of IL‐1β, IL‐6, NF‐kB, and TNF‐α. In addition, the acute administration of ABGE (0.03–1 g kg−1) dose‐dependently relieved post‐inflammatory visceral pain, with the higher dose (1 g kg−1) able to significantly reduce both the behavioral nociceptive response and the entity of abdominal contraction (assessed by electromyography) in response to colorectal distension after the acute administration in DNBS‐treated rats. Present findings showed that ABGE could represent a potential strategy for treatment of colitis‐associated inflammatory process and visceral pain. The beneficial effects induced by the extract could be related to the pattern of polyphenolic composition, with particular regard to gallic acid and catechin.

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Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2–NFκB pathways

Cited by 11 publications

References 41 publications

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

Anti‐inflammatory and anti‐hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis‐associated visceral pain

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