Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice

Cho, Byoung Ok; Yin, Hong; Fang, Chong Zhou; Jeong, Seung Il; Jang, Seon Il

doi:10.1007/s10068-015-0294-6

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…The results revealed that DLE administration reduced the levels of AST, ALT and ALP, suggesting that DLE attenuated the liver damage caused by HFD. The author's previous study has also demonstrated similar activities in acetaminophen-induced acute liver damage in mice (38).…”

Section: Discussionmentioning

confidence: 65%

“…In previous studies, plant extracts have been reported to protect against obesity-induced oxidative damage in mice (41,42). Our previous study also demonstrated that DLE protects against UVB-induced oxidative damage and acetaminophen-induced oxidative liver damage in mice (38,43). Therefore, it can be suggested that DLE may be a potent antioxidant used for preventing the oxidative stress associated with HFD-induced obesity.…”

Section: Discussionmentioning

confidence: 80%

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Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Kim

Cho²,

Jang³

2018

Int J Mol Med

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Diospyros (D.) lotus has been demonstrated to have antioxidant and anti-inflammatory properties. The purpose of the present study was to evaluate the effect of D. lotus leaf water extract (DLE) on high-fat diet (HFD)-induced obesity in c57BL/6 mice. The present study first investigated the effect of DLE on the lipid accumulation and triglyceride (TG) contents in 3T3-L1 cells, and the results revealed that treatment with DLE suppressed the lipid accumulation and TG level. Subsequently, the anti-obesity effects of DLE were investigated in vivo. Oral administration of DLE reduced the body weight gain, food efficiency ratio, and liver and visceral fat weight in mice fed with a HFD. DLE administration in these mice also reduced TG, total cholesterol, low-density lipoprotein cholesterol, glucose, insulin and leptin levels, as well as the atherogenic index. Furthermore, DLE administration decreased hepatic steatosis, as well as serum aspartate transaminase, alanine transaminase and alkaline phosphatase levels in mice fed with HFD. It was further observed that treatment of the HFD-fed mice with DLE prevented lipid peroxidation, while it recovered glutathione depletion and the activities of superoxide dismutase, catalase and glutathione peroxidase. In conclusion, the current study suggests that the anti-obesity effect of DLE may provide positive insights as a potential functional food ingredient for the prevention of obesity.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 80%

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Kim

Cho²,

Jang³

2018

Int J Mol Med

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“…The protein expression of hepatic TNF-α is increased 4 hr after APAP treatment and gets to the highest level at 10 hr (Ishida et al, 2004). n = 6 are increased in primary human hepatocytes and mice with APAP treatment (Cho et al, 2015;Kim et al, 2017). Moreover, TNF-α can induce the release of other proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, TNF-α can induce the release of other proinflammatory cytokines. The levels of IL-6 and IL-12 are increased in primary human hepatocytes and mice with APAP treatment (Cho et al, 2015;Kim et al, 2017). Inhibition of proinflammatory cytokines production attenuates inflammation-mediated hepatocyte injury following APAP toxicity (Devkar et al, 2016;Hussan et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Silkworm pupa oil attenuates acetaminophen‐induced acute liver injury by inhibiting oxidative stress‐mediated NF‐κB signaling

Long

Song

Zhao

et al. 2019

Food Science & Nutrition

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Acetaminophen (APAP) overdose causes severe hepatotoxicity and acute liver failure. The current study aims to investigate the protection effects of silkworm pupa oil (SPO) against acute hepatic injury in APAP‐exposed Kunming mice. Our results showed that the liver index and the levels of serum alanine transaminase (ALT) and aspartate transaminase (AST) in mice subjected to APAP treatment were decreased by SPO. Supplement of SPO also restored hepatic histopathological alterations induced by APAP. The APAP‐induced increase in proinflammatory cytokines, including TNF‐α, IL‐6, and IL‐12, was reversed by SPO, which was mediated by the reduction of nuclear factor (NF)‐κB p65 expression and the increase in the expression of IκB‐α in liver tissue. Moreover, SPO inhibited APAP‐triggered oxidative stress by decreasing MDA level and increasing the activities of SOD and GSH‐Px. Collectively, SPO attenuated hepatic injury induced by APAP, which attributed to the suppression of oxidative stress‐mediated NF‐κB signaling. Our findings suggest that SPO supplementation may be potential strategy against acute hepatic injury.

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“…Furthermore, lotus is a traditional medicinal plant in Asian countries including China, ailand, India, Japan, and Korea [4,5]. In traditional Chinese medical science, lotus seeds have the functions of invigorating the spleen, stopping diarrhea, tonifying the kidney, astringent essence, nourishing the heart, and calming mind [6,7]. In Korea, the lotus seed is one of the most well-known traditional herbal medicines for the treatment of cardiovascular diseases [8].…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of the Freshness of Lotus Seeds Using Surface Desorption Atmospheric Pressure Chemical Ionization-Mass Spectrometry with Multivariate Analyses

Chi

Huang

et al. 2019

Journal of Food Quality

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In order to explore a new method to detect the freshness of lotus seeds, the lotus seeds stored for 0, 1, 2, and 3 years, respectively, were used as experimental materials and analyzed by DAPCI-MS (desorption atmospheric pressure chemical ionization-mass spectrometry). The obtained data were processed by principal component analysis (PCA) and backpropagation artificial neural networks (BP-ANNs). The result showed that DAPCI-MS could obtain abundant chemical material information from the slice surface of lotus seeds. The BP-ANNs model could be applied not only to distinguish fresh and aged lotus seeds with the testing set accuracies of 95.0% and 91.7%, respectively, but also to classify lotus seeds with different storage times with the testing set accuracies of 90.0%, 85.0%, 85.0%, and 90.0%, respectively. The paper developed a fast, convenient, and accurate method for the freshness detection of lotus seed and would provide reliable reference value for rapid authentication of food freshness by the rapid mass spectrometry technique.

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Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice

Cited by 13 publications

References 30 publications

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Silkworm pupa oil attenuates acetaminophen‐induced acute liver injury by inhibiting oxidative stress‐mediated NF‐κB signaling

Rapid Determination of the Freshness of Lotus Seeds Using Surface Desorption Atmospheric Pressure Chemical Ionization-Mass Spectrometry with Multivariate Analyses

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