Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin

Abstract

Cirsium japonicum DC is a perennial plant that is widely distributed throughout China. Flavonoids are the major active constituents of C. japonicum, which has been reported to possess many bioactivities. This study was designed to investigate the protective effects of flavonoids from C. japonicum against liver injury using carbon tetrachloride (CCl4)-induced hepatocyte injury, with silymarin as a positive control. Silymarin is a mixture of flavonoids from Silybum marianum, a traditional European food plant with clear hepatoprotective effects. The results indicated that the pretreatment with C. japonicum flavonoids could significantly reverse CCl4-induced L02 cell viability decrease similarly to silymarin. Analysis of flavonoids of C. japonicum and silymarin by HPLC showed that these two mixtures may contain one common component, which may be the major active ingredient responsible for their hepatoprotective effects. It is concluded that C. japonicum could be developed into functional foods with hepatoprotective efficacy, similarly to S. marianum.

Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice

“…ABTS scavenging ability was assessed according to a previously described method [ 50 ], with some modifications. In specific, ABTS+ was prepared by mixing ABTS stock solution (5 mL, 7 mM in pH 7.4 phosphate buffer solution) with 2.45 mM potassium persulfate (5 mL).…”

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

“…Chinese physicians usually use CH to treat hemorrhage, hypertension, and hepatitis. Recent pharmacological reports indicated that CH exhibits various pharmacological activities such as hemostatic, hepatoprotective, antidiabetic, anti-inflammatory, antibacterial, and sedative activities [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Due to its taxonomy (Asteraceae family) and morphology being similar to Silybum marianum (L.) Gaertn.…”

A review for discovering hepatoprotective herbal drugs with least side effects on kidney

“…Hepatoprotective effects of silymarin on carbon tetrachloride (125,126), phenylhydrazine (127,128), tert-Butyl hydroperoxide (129), thioacetamide (130,131), galactosamine (129,132), paracetamol (133), erythromycin estolate (134,135), microcystin (136) and amanita phalloids toxin (137) have been shown. Numerous studies have suggested that silymarin has significant antiinflammatory effects on hepatic tissue and that it regulates inflammatory mediators such as tumor necrosis factor (TNF) (120), TNF-alpha (138), interleukin-6, nitrous oxide, and interleukin-1 receptor antagonist (139).…”