Hepatoprotective Effect of Indigenous Medicinal Plants-A Review

Abstract

Liver is an important part in human beings and plays a very important and major role in metabolism and excretion of xenobiotics from the body. Further, hepatotoxicity is caused by different types of toxic chemicals, such as antibiotics and chemotherapeutic agents, paracetamol (C 8 H 9 NO 2 ), thioacetamide (C 2 H 5 NS), carbon tetrachloride (CCl 4 ), silymarin (C 2 5H 22 O 10 ), ethanol (C 2 H 5 OH) and excessive alcohol intake and microbes is well researched. The markedly available synthetic drugs to treat liver sickness in this condition also cause further damage to the liver. Therefore, herbal medicines have become increasingly famous and their utilization is wide-spread. In medicinal plant derived drugs, that have been utilized in the treatment of liver diseases for a long time, the protection of a healthy liver has been essential for the overall well-being of an individual. Liver injury induced by toxins is more common now-a-days. Herbal remedies are focused in the pharmaceutical industry to evolve a safe route for liver disorders and it is very low cost, no side effects compared with synthetic drugs. Therefore, hepatoprotective plants such as Avicennia alba, Anisochilus carnosus, Baliospermum montanum, Centella asiatica, Clitoria ternatea, Eclipta alba, Justicia adhatada, Phyllanthus emblica, Pisonia grandis and Syzgium cumini were reviewed. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.

Hepatoprotective effect of the ethanol extract of Detarium senegalense stem bark in albino Wistar

“…A single drug cannot be effective for all types of severe liver diseases. Therefore, an effective formulation using indigenous medicinal plants has to be developed with proper pharmacological experiments and clinical trials [9].…”

The Potential of Purple Sweet Potato-based Food Bar as an Immunomodulator and Hepatoprotector Against Diethylnitrosamine-induced Mice

“…Liver damage can be prevented by utilizing compounds with hepatoprotective properties, where these compounds can mitigate the effects of toxic substances that may damage the liver or even repair damaged liver tissue. Some bioactive plant compounds responsible for hepatoprotective effects include polyphenols, flavonoids, tannins, ascorbic acid, and polysaccharides [12].…”

Quantitative ethnobotanical study in Gafargaon Sub-district and unveiling drug candidates through molecular docking and dynamics simulation approaches

“…Over 50% of all pharmaceutical drugs can be traced back to their origins in ethnomedicine (Van Wyk et al, 1997;Suchana et al, 2022). Recently, the use of ethnomedicinal plant-based formularies have gained popularity over the use of synthetic drugs focusing issues, such as safety and efficacy which demands a more rigorous and scientific documentation of indigenous medicinal knowledge (Minnady et al, 2022). Lack of plant identification skill is a hindrance to this endeavor which might results in inappropriate selection of taxa for specific ailment and at this point taxonomic expertise is very much essential (Hadiati et al, 2022).…”