Hepatoprotective Effect of Lactobacillus Plantarum Against Salmonella Typhimurium in Mice

Zedan, Zahraa K.

doi:10.22401/jnus.14.4.17

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Comparing the results to the positive control which is the silymarin, there is only a slight elevation of the serum ALT in the group treated with lactic acid bacteria. This is also the same to the study of Zedan [11], wherein the capacity of Lactobacillus plantarum to protect the liver was elucidated by the low levels of AST and ALT in the serum of mice [11].…”

Section: Journal Of Dairy and Veterinary Sciencessupporting

confidence: 62%

Hepatoprotective and Histologic effects of Lactic Acid Bacteria on Carbon Tetrachloride – Induced Liver Injury in Albino Rats (Rattus Albus)

Hinay

2019

JDVS

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Liver disease has long been a problem to the public health. There are different etiologic agents to this problem such as hepatotoxins and alcoholism, which contribute to liver damage or necrosis, biologic factors such as bacteria, parasites and viruses, metabolic diseases, and even drug exposure to paracetamol or carbon tetrachloride etc. Hence, a growing need to provide an effective and safe drug has become a trend because current modern available drugs have side effects and bring about inherent toxicities. Two locally known commercially fermented products were used as the source of lactic acid bacteria. These were the coconut toddy (tuba) and Visayan fermented fish (guinamos). Three distinct colonies were isolated -two from the guinamos coded as GUI -01 and GUI -02, and one from the tuba coded as TUB -01. However, only the colony isolated from tuba was subcultured in MRS broth as it was stipulated in the delimitations of the study to use only bacteria of genus Lactobacillus. The colony isolated from the tuba was characterized as Gram positive, catalase negative, oxidase negative, non -spore forming bacilli in single and clusters. The MRS broths incubated for 72 hours at 37ºC were pelleted by centrifugation and re-suspended in 0.1M Phosphate Buffer Solution (pH 7.4).The isolates were investigated for their hepatoprotective and histologic effects on carbon tetrachloride -induced liver injury in Albino rats (R. albus), along with Silymarin as the positive control. For four days, the albino rat test groups were administered with a single dose lactic acid bacteria suspension, while positive control group was induced with a single dose silymarin. Results showed only slight elevations of serum ALT and AST on group induced with LAB, as compared to the levels of serum ALT and AST on group induced with silymarin. Using One -way Analysis of Variance, it was suggested that lactic acid bacteria has comparable effects to the hepatoprotective effects of Silymarin against carbon tetrachloride. This result was supplemented by the histopathologic exams of rat liver sections showing normal histology.

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Section: Journal Of Dairy and Veterinary Sciencessupporting

confidence: 62%

Hepatoprotective and Histologic effects of Lactic Acid Bacteria on Carbon Tetrachloride – Induced Liver Injury in Albino Rats (Rattus Albus)

Hinay

2019

JDVS

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“…Moreover, recent several studies have shown that specific strains of probiotics are effective at inhibiting the liver injury, or hepatic encephalopathy (HE) (Nanji et al, 1994;Kim et al, 2003;Solga, 2003;Zhao et al, 2004;Han et al, 2005a;Osman et al, 2007;Yun et al, 2007;Zedan, 2011;Ou et al, 2012;Wang et al, 2013). In addition, in a previous study, we found B. adolescentis SPM0212 has potential anti-hepatitis B virus activity (Lee et al, 2013).…”

mentioning

confidence: 60%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

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Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

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Hepatoprotective Effect of Lactobacillus Plantarum Against Salmonella Typhimurium in Mice

Cited by 2 publications

References 17 publications

Hepatoprotective and Histologic effects of Lactic Acid Bacteria on Carbon Tetrachloride – Induced Liver Injury in Albino Rats (Rattus Albus)

Hepatoprotective and Histologic effects of Lactic Acid Bacteria on Carbon Tetrachloride – Induced Liver Injury in Albino Rats (Rattus Albus)

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

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