Hepatoprotective effect of leaf extracts of &lt;i&gt;Crassocephalum rubens&lt;/i&gt; (Juss. ex Jacq.) S. Moore in rifampicin-induced oxidative stress in Swiss mice

Omoregie, Ehimwenma Sheena; Okugbo, Osariemen Tinu; Oikeh, Ehigbai I.; Irabor, Francis

doi:10.4314/jpb.v12i2.5

Cited by 5 publications

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“…The level of proanthocyanidins in plant extracts has been associated with several in vitroantioxidant activities. This result agrees with those recorded by other researcherswho reported the presence of some phytochemicals in different solvent extracts of the leaves, fruit or other plant parts of A. boonei and other plant species [Omoregie et al, (2014); Olubodun and Osagie, (2016); Olubodun et al, (2021)]. The observed differences may be a result of the differences in the plant materials, the variety of chemical constituents in the plant materials and their differing solubility properties in different solvents, the compounds to be isolated and/or methods of extraction (Olubodun et al, 2021).The study revealed that ethanol is better for extraction of phytochemicals in A. boonei stem-bark when compared with aqueous extraction The potential antioxidant activities of phytochemicals were suggested to be the reason for their medical properties since oxidative stress is implicated in most disease conditions (Nkono et al, 2014).…”

Section: Discussionsupporting

confidence: 93%

“…In the result of this study, there was a slight increase in the reductive potential as concentration increased, especially in the ethanol extract, while the aqueous extract maintained a relatively steady range. This study agrees with the study of other researchers who recorded that A. boonei leaves (Omoregie et al, 2014), root-bark possesses antioxidant effects (Obiagwu et al, 2014). This study therefore suggests that the antioxidant activity of the extracts of A. boonei may be responsible for its medicinal properties, hence its use for the management of different ailments.…”

Section: Discussionsupporting

confidence: 92%

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Comparative Analysis of Phytochemical Constituents and Antioxidant Properties of Aqueous and Ethanol Extracts of Alstonia boonei Stem-Bark

Izum,

Olubodun

2023

The Bioscientist Journal

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The plant Alstonia boonei is extensively used in traditional medicine because of its therapeutic properties. Over the years, researchers have been looking for the active medicinal agents in different plant species and as such, the type of extraction solvent plays a major role. This study aim to investigate the comparative analysis of phytochemical constituents and antioxidant properties of aqueous and ethanol extracts of A. boonei stem-bark. The stem-bark of A. boonei was collected, dried, pulverized and extracted with ethanol and distilled water using maceration method. The extract was concentrated in a temperature regulated water bath set at 45oC. Qualitative and quantitative phytochemical analysis was carried out in both extracts. Both extracts was also subjected to various antioxidant analytical procedures such as free radical scavenging capacity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH), reducing power, and ferric reducing antioxidant power (FRAP) to determine antioxidant properties. The qualitative phytochemical analysis of both extracts revealed the presence of flavonoids, cardiac glycoside, terpenoids, alkaloids and saponins. However, quantitative studies revealed that proanthocyanidin, flavonoids and total phenol were significantly higher in ethanol extract compared to aqueous extract (p < 0.05). Both extracts exhibited antioxidant activities compared to reference antioxidant (Ascorbic acid). However, the reducing power of the aqueous extract was significantly higher than that of the ethanol extract.This result indicates that aqueous extract of A. booneistem-bark had lower phytochemical constituents but higher antioxidant activity compared to ethanol extract. The result of this study revealed that ethanol may be a better solvent for phytochemical extraction of A. boonei stem-bark.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Comparative Analysis of Phytochemical Constituents and Antioxidant Properties of Aqueous and Ethanol Extracts of Alstonia boonei Stem-Bark

Izum,

Olubodun

2023

The Bioscientist Journal

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“…These uncommon vegetable types of medicinal plants are only available in local markets and rural areas [3,4], which explains the limited research data available. They are used traditionally for the treatment of diabetes, body pains, wounds, arthritis, fever, cancer, ulcer, and epilepsy and have been reported to display antioxidant, antimicrobial, anti-inflammatory, anticancer, wound healing, and antiulcer activities [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

African Under-Utilized Medicinal Leafy Vegetables Studied by Microtiter Plate Assays and High-Performance Thin-Layer Chromatography–Planar Assays

Oresanya,

Orhan,

Heil

et al. 2024

Molecules

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Biological activities of six under-utilized medicinal leafy vegetable plants indigenous to Africa, i.e., Basella alba, Crassocephalum rubens, Gnetum africanum, Launaea taraxacifolia, Solanecio biafrae, and Solanum macrocarpon, were investigated via two independent techniques. The total phenolic content (TPC) was determined, and six microtiter plate assays were applied after extraction and fractionation. Three were antioxidant in vitro assays, i.e., ferric reducing antioxidant power (FRAP), cupric reduction antioxidant capacity (CUPRAC), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, and the others were enzyme (acetylcholinesterase, butyrylcholinesterase, and tyrosinase) inhibition assays. The highest TPC and antioxidant activity from all the methods were obtained from polar and medium polar fractions of C. rubens, S. biafrae, and S. macrocarpon. The highest acetyl- and butyrylcholinesterase inhibition was exhibited by polar fractions of S. biafrae, C. rubens, and L. taraxacifolia, the latter comparable to galantamine. The highest tyrosinase inhibition was observed in the n-butanol fraction of C. rubens and ethyl acetate fraction of S. biafrae. In vitro assay results of the different extracts and fractions were mostly in agreement with the bioactivity profiling via high-performance thin-layer chromatography–multi-imaging–effect-directed analysis, exploiting nine different planar assays. Several separated compounds of the plant extracts showed antioxidant, α-glucosidase, α-amylase, acetyl- and butyrylcholinesterase-inhibiting, Gram-positive/-negative antimicrobial, cytotoxic, and genotoxic activities. A prominent apolar bioactive compound zone was tentatively assigned to fatty acids, in particular linolenic acid, via electrospray ionization high-resolution mass spectrometry. The detected antioxidant, antimicrobial, antidiabetic, anticholinesterase, cytotoxic, and genotoxic potentials of these vegetable plants, in particular C. rubens, S. biafrae, and S. macrocarpon, may validate some of their ethnomedicinal uses.

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“…Traditionally, C. rubens is used as a nutraceutical and believed to have antibiotic, anti-helminthic, antiinflammatory, anti-diabetic, anti-malaria and blood regulation properties, and also treats indigestion, liver complaints, colds, intestinal worms and hepatic insufficiency [2,3]. Antimicrobial and hepatoprotective effects of the leaves of Crassocephalum rubens have been reported [4,5]. Also the antimicrobial, hepatoprotective, antioxidant, antinociceptive, anti-inflammatory, anthelmintic and cancer chemo-preventive actions of some species of the Crassocephalum genus are well established [6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Aerial Parts of Crassocephalum rubens (Juss. ex Jacq.) S. Moore and Cardiospermum grandiflorum (Sweet) Stem

Olaoluwa

Oladosu

Aiyelaagbe

et al. 2018

JOCAMR

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Aim: This paper presents the essential oils constituents of aerial parts of Crassocephalum rubens and stem of Cardiospermum grandiflorum. C. rubens is a Nigerian vegetable used as a nutraceutical and traditionally has been used as antibiotic, anti-helminthic, anti-inflammatory, antidiabetic, anti-malaria and blood regulating agents. C. grandiflorum (Sapindaceae) is considered a noxious weed in Australia and South Africa. The leaves are taken as vegetable in Ghana and have application for dermatological troubles, chest problems and fever. The plant has also been used in the treatment of jaundice, cough and kidney problems. Methodology: The essential oils were obtained by hydro-distillation in a Clevenger-type apparatus Short Communication

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Hepatoprotective effect of leaf extracts of <i>Crassocephalum rubens</i> (Juss. ex Jacq.) S. Moore in rifampicin-induced oxidative stress in Swiss mice

Cited by 5 publications

References 0 publications

Comparative Analysis of Phytochemical Constituents and Antioxidant Properties of Aqueous and Ethanol Extracts of Alstonia boonei Stem-Bark

Comparative Analysis of Phytochemical Constituents and Antioxidant Properties of Aqueous and Ethanol Extracts of Alstonia boonei Stem-Bark

African Under-Utilized Medicinal Leafy Vegetables Studied by Microtiter Plate Assays and High-Performance Thin-Layer Chromatography–Planar Assays

Essential Oils of Aerial Parts of Crassocephalum rubens (Juss. ex Jacq.) S. Moore and Cardiospermum grandiflorum (Sweet) Stem

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