Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats

Sunitha, Sukumaran; Nagaraj, M.; Varalakshmi, P.

doi:10.1016/s0367-326x(01)00259-3

Cited by 153 publications

(104 citation statements)

References 26 publications

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“…As the title plant is rich in curcuminoids, it may be responsible for wound healing activity. The plant extracts also shows antioxidant activity i.e., free radical scavenging activity which might reduces lipid peroxidation, may not only prevent or slows down the onset of necrosis but also improve vascularity 32 . The experimental plant also shows antimicrobial activity as reported earlier these are the factors count for wound healing activity of Curcuma longa rhizomes.…”

Section: Discussionmentioning

confidence: 99%

Potential of Ethanolic Extract of Ficus Benghalensis on Open Wounds and Inflammation

Charde¹,

Dhongade²,

Charde³

et al. 2012

Int Jour of Pharmc Res

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AbstractsThe present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of Curcuma longa Linn rhizomes. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the study was supported with evaluation of granuloma tissue to estimate hydroxyproline content and histopathological evaluation. The anti-inflammatory study was carried out by using carageenan induced rat paw odema method. The tested extract of different dilutions in range 200µg/ml to 1000 µg/ml shows activity in range of 9.34% to 18.55%. Significant increase in wound closure rate, skin breaking strength, granuloma breaking strength was observed. The hydroxyproline content was also increased with decrease in scar area. The initial healing action might be due to increased collagen deposition and better alignment, with the obtained results it can be concluded that Curcuma longa extract has significant wound healing activity and initial healing may be due to presence of some terpenoids and antimicrobial agents. The extract shows prominent anti-inflammatory activity as compared to that of standard (Ibuprofen gel). The extract shows good anti-inflammatory activity on carageenan induced rat paw odema method.

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Section: Discussionmentioning

confidence: 99%

Potential of Ethanolic Extract of Ficus Benghalensis on Open Wounds and Inflammation

Charde¹,

Dhongade²,

Charde³

et al. 2012

Int Jour of Pharmc Res

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show abstract

“…In Wistar rats, lutein and lycopene treatment caused lower numbers of hepatic placental glutathione S-transferase-positive pre-neoplastic lesions in the liver and lower hepatic DNA strand breakage (Toledo et al, 2003). Other natural antioxidants such as lupeol and pomegranate extracts all have prevention and treatment effects in liver disease (Sunitha et al, 2001). We believe that with the development of better and synthetic chemistry purification technology the rational design of suitable antioxidant mixtures may find use in the prevention of HCC, cirrhosis and other liver diseases.…”

Section: Steroidsmentioning

confidence: 99%

NF-κB signaling, liver disease and hepatoprotective agents

2008

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“…Linomat V autosampler was used for spotting of standard lupeol (2,4,6,8,10, and 12 µl each) and sample solutions (10 µl each) operated with 6 mm band length, distance between the tracks 10 mm, distance from the bottom of the plate, 8.0 mm. The linear ascending developments were carried out up to a distance of 75 mm in a CAMAG twin trough chamber presaturated with mobile phase toluene:methanol:formic acid (7:3:0.3 v/v) for 25 minutes, and anisaldehyde is used as derivatizing reagent.…”

Section: Chromatographic Analysismentioning

confidence: 99%

“…The different concentrations (2,4,6,8,10, and 12 ng spot −1 ) of lupeol were applied on the HPTLC plate in triplicates, separately. The plate was developed as prescribed above.…”

Section: Linearitymentioning

confidence: 99%

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Lupeol Validation and Quantification in Heteropogon Contortus (L.) Beauv. (Spear Grass) Through High-Performance Thin-Layer Chromatography

Kaur

Gupta

2017

Asian J Pharm Clin Res

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Objective: This is aimed to study the chromatographic evaluation of triterpenoid, i.e., lupeol from methanolic extracts of leaves, stem, and inflorescence of Heteropogon contortus. Methods:The high-performance thin-layer chromatography (HPTLC) densitometry determination of lupeol was performed using optimized mobile phase toluene:methanol:formic acid (7:3:0.3 v/v) with a derivatization of freshly prepared anisaldehyde-sulfuric acid. For densitometry measurements, the plates were scanned at 530 nm absorbance/reflectance wavelength. Quantification of lupeol marker compound in H. contortus leaves, stem, and inflorescence is estimated using 2-12 µg/spot. Results:The appearance of light purple bands on the chromatograms confirmed the lupeol component in plant samples. Further, the confirmation of the compound is done from the densitometric scanning by comparing λ max values. From this, it is reported that lupeol is present in leaf samples, i.e., 10 mg/g of dry wt., while in rest of the two samples, it is found absent. Conclusion:The leaves of H. contortus (spear grass) are a good source of lupeol and can be used as an alternate natural source to synthesize herbal drugs to control cancer and other anti-inflammatory agents. The presently selected HPTLC is validated and most accurate for the quantification and identification of lupeol present in the selected plant. The leaves of the species which are rich in lupeol can be used in pharmaceutical industry.

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Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats

Cited by 153 publications

References 26 publications

Potential of Ethanolic Extract of Ficus Benghalensis on Open Wounds and Inflammation

Potential of Ethanolic Extract of Ficus Benghalensis on Open Wounds and Inflammation

NF-κB signaling, liver disease and hepatoprotective agents

Lupeol Validation and Quantification in Heteropogon Contortus (L.) Beauv. (Spear Grass) Through High-Performance Thin-Layer Chromatography

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