Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats

Ajibola, Meraiyebu; Adetunji, Charles Oluwaseun; A, Stephanie; Joseph, Dare; Denen, Atsukwei

doi:10.11648/j.ajbls.20130104.12

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…Other than previously mentioned activities, the P. biglobosa extract has also been demonstrated to have antimalarial effect [ 11 ], whereas P. clappertoniana [ 75 ] and P. biglobosa [ 216 ] show nephro- and hepatoprotective effects, respectively ( Table 3 ). P. pendula seeds also enhance wound healing in immunosuppressed mice [ 217 ].…”

Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Saleh

Jalil

Zainalabidin

et al. 2021

IJMS

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The genus Parkia (Fabaceae, Subfamily, Mimosoideae) comprises about 34 species of mostly evergreen trees widely distributed across neotropics, Asia, and Africa. This review aims to provide an overview of the current status of the species from the genus Parkia in terms of its relationship between its phytochemistry and medical uses. Comprehensive information on Parkia species was retrieved from electronic databases, which were Web of Science, ScienceDirect, PubMed, and Google Scholar. This review identified nine species from genus Parkia with properties of medicinal use. They are used traditionally to treat several ailments, such as diabetes, diarrhea, wounds, hypertension, cough, chronic piles, conjunctivitis, and measles. The most common species studied are P. biglobosa, P. speciosa, P. javanica, P. bicolor, P. biglandulosa, P. filicoidea, and P. clappertoniana. A considerable number of secondary metabolites, such as terpenoids, phenolic acids, flavonoids (aglycone and glycosides), and numerous volatile compounds have been identified in this genus, which are responsible for their diverse pharmacological activities. Their extracts, pure compounds and seed lectins have been reported for their anticancer, antimicrobial, antihypertensive, antiulcer, antidiabetic, anti-inflammatory, antioxidant, antimalarial, hepatoprotective, and antidiarrheal activities. The information gathered in this review might be of help for future studies in terms of the current knowledge on the link between the phytochemical components and medicinal uses. This could facilitate more discoveries on its potentials particularly in the pharmacological characteristics and potential to be developed into modern medicines.

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Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Saleh

Jalil

Zainalabidin

et al. 2021

IJMS

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“…In addition,hepatoprotective effect of Azadirachtaindica was also shown to be comparable to that of vitamin E in this investigation. As a result, when Azadirachtaindica or vitamin E was used as a pretreatment in a corresponding dose for a period of time, hepatocyte damage was prevented 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous study explained that the hepatoprotective effect of Azadirachtaindica was found to be equivalent to that of vitamin E. As a result, pretreatment with Azadirachtaindica or vitamin E decreased hepatocyte damage, which could be related to antioxidative and lipid peroxidation inhibition property of Azadirachtaindica. These properties of Neem leaves play a fundamental role in fight against free radicals and other oxidant storms 2,18 . Histopathological findings from different resources showed that AzadirachtaIndica and Vitamin E has also a positive influence on biochemical parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The United State National Academy of Sciences has issued a report with the title, "Neem-a tree for solving global problem", which aimed to review all aspects of Neem tree including biological activities, pharmacological actions, clinical trials, and possible medicinal application of neem compounds or extracts together with their safetyvaluation. The leaves of the this tree have beneficial effects and are traditionally used in preparations of a lot ofmedicines havingimmunomodulatory, anti-hepatotoxicity, anti-oxidative stress, anti-inflammatory, anti-hyperglycemic, anti-ulcer, anti-malarial, anti-fungal, anti-bacterial, anti-viral, anti-mutagenic, and anticarcancereffects 2,9 . AzadirachtaIndica has an anti-oxidant and chemoprotective effect which is due to the presence of several active compounds like quercetin, nimbin, nimbidiol, azadirachtin, and nimbidin.Mallicket al hasconfirmed that neem leaves extract has non-toxic effect on liver and kidney of rats, even in higher doses 8 .…”

Section: Introductionmentioning

confidence: 99%

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Antioxidative Role of Azadirachta Indica Vit. E in Restoration of Histopathological changes in Acetaminophen induced liver

Sodha¹,

Abbasi²,

Mawani³

et al. 2021

PJMHS

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Aim: To study the comparative effect of Acetaminophen induced liver toxicity with aqueous extract of Azadirachta Indica (Neem) and vitamin E on the basis of liver Histopathology. Methods: Sixty Wistar Rats of both sexes were split into four groups. Each group contained 15 animals. The control group was group A, Group B was treated orally with single dose of Paracetamol 2 mg / kg by weight, Group C was administrated orally with aqueous Neem extract 500 mg/kg +2 mg/Kg by weight oral Paracetamol, and Group D was given orally paracetamol+Neem extract+Vitamin E with 100mg/Kg/body weight for 15 days. Rats from all groups were decapitated, the liver was sliced, and liver tissues were taken for histological examination. Tissue samples were fixed in 10% formaldehyde, embedding in paraffin followed by Hematoxylin and Eosin dye (H&E) and observed under 400x magnification with a digital microscope. Results: On Histopathological examination of the rat`s liver in we found that the control group had a normal appearance, colour, and uniform surface without any necrosis. Group B showed severe necrosis and haemorrhagic patches. In comparison, Group C revealed normal appearance, colour, and smooth surface with no necrotic alterations. Livers from the group D looked virtually normal in terms of colour, undersurfaces, and organ weight. However, hepatoprotective effects were observed in the Group C and D. Therefore, we can conclude that Azadirachta indica and Vitamin E could serve as a good medication for defence against liver injury. Conclusion: Our findings showed thatextract of Azadirachta Indica and Vitamin E exhibited hepatoprotective effects on the Wistar rats that were subjected to Acetaminophen. Key words: Azadirachta Indica leaf extract, Vitamin E, hepatoprotective Paracetamol, Wistar rats.

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“…The Voucher number ABU/7064 was given to the sample which was deposited to the herbarium in the same Department for reference purposes. The methods of Soetan et al and Meraiyebu et al [16,17] was used to processed plant sample. The extration was done with a Soxhlet's apparatus for 4 hours using the methods of Asuzu and Onu and Builder et al [18,19].…”

Section: Collection Processing and Extraction Of Plant Materialsmentioning

confidence: 99%

Acute Toxicity Profile of Crude Methanolic Stem Bark Extract of Parkia Biglobosa in West African Dwarf (Wad) Goats

Josiah,

Adama,

Obi

et al. 2023

Preprint

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Despite the high demand for herbal medicines for treatment of health disorder, there are still concerns associated with not only their use, but their safety. This study aimed at providing information on the potential toxicity profile of the stem bark extracts of P. biglobosa in goats. For this purpose, the stem bark parts of P. biglobosa were collected and processed. The acute toxicity, biochemical and histopathological analysis in goats were determined. The results of phytochemical constituents revealed the presence of alkaloids, anthraquinones, cardiac glycosides, glycosides, oils, phlobatannins, reducing sugar, saponins and tannins (condensed and hydrolysable). The results of acute toxicity studies showed no mortality with up to 5000 mg/ kg of the body weight. The blood collected revealed that, CMSBE, have no significant (P>0.05) effect on biochemical parameters of WAD goats . However, there were slight changes in glucose concentration, cholesterol and triglyceride level, though they were no statistically significant (P>0.05). The extracts did not also have deleterious effect on morphology of the tissues observed during histopathology. The study has scientifically demontrated that, stem bark extract of P. biglobosa have LD50 that is greater than 5,000 mg/kg and it can be inferred that the plant might have a wide margin of safety typical of treatment of some diseases. It is therefore recommended that despite the non-toxicity as demonstrated in this present study, detailed toxic and pharmacological effects of the extracts of P. biglobosa stem bark in other animals should be investigated.

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Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats

Cited by 5 publications

References 14 publications

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Antioxidative Role of Azadirachta Indica Vit. E in Restoration of Histopathological changes in Acetaminophen induced liver

Acute Toxicity Profile of Crude Methanolic Stem Bark Extract of Parkia Biglobosa in West African Dwarf (Wad) Goats

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