Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury in mouse

Chen, Chen; Liu, Xiang; Qi, Shanshan; Dias, Alberto Carlos Pires; Yan, Jun; Zhang, Xiaoying

doi:10.1016/j.ijbiomac.2019.11.002

Cited by 26 publications

(12 citation statements)

References 27 publications

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“…In our study, growth factors in fetus livers were investigated in pregnant rats given paracetamol. Depending on the dose of paracetamol, VEGF-A, FETU-A and SOST values increased and the VEGF-A and FETU-A were found to be similar to other studies [25]. More clinical and experimental studies are needed to determine the extent to which paracetamol affects the organs and development of the fetus in pregnant women.…”

Section: Discussionsupporting

confidence: 52%

Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses

et al. 2020

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Amaç: Parasetamol gebe, çocuk ve yaşlılar gibi önemli gruplar tarafından yaygın olarak kullanılmaktadır. Özellikle gebelikte fazla dozda alınan parasetamol karaciğer yetmezliklerine neden olmaktadır. Çalışmamızın amacı gebelik döneminde yaygın olarak olarak kullanılan parasetamolün fetüs karaciğeri üzerine etkilerini biyokimyasal olarak araştırmaktır. Yöntemler: Çalışmamızda 10 adet (n=2) gebe sıçanlardan Wistar Albino cinsi rastgele seçilen kontrol grubu, 50 mg/kg parasetamol grubu, 125 mg/kg parasetamol grubu, 250 mg/kg parasetamol grubu ve 500 mg/kg parasetamol grubu olmak üzere beş gruba ayrıldı. Gavaj yoluyla parasetamol, belirlenen dozlarda gebe sıçanlara verildi. Gebeliğin 20. gününde sezeryan ile fetüsler alındı (her gruptan 10 adet fetus alındı). Sonrasında fetus karaciğerleri biyokimysasal analiz için alındı. Biyokimyasal olarak vascular endothelial growth factor A (VEGF-A), FETU-A (α2-heremans-schmid glikoprotein) ve Sclerostin (SOST) değerleri incelendi. Bulgular: Bu çalışmada parasetamol dozu arttıkça karaciğer hepatosit hücrelerinde değişiklikler görülmektedir. VEGF-A ve FETU-A'da düzenli artış görülmektedir. SOST ise 250 mg/kg dozunda yükselirken, 500 mg/kg parasetamol grubunda azalmıştır. (p<0.05) Sonuç: Sonuç olarak gebelikte yüksek dozda parasetamol kullanımının fetüskaraciğerinde ve biyokimyasal değerde değişiklik meydana getirdiği görülmektedir. Bu çalışmada gebelikte masum analjezik olarak reçetesiz satılan ve çok kullanılan parasetamol'un yüksek dozda kullanımı konusunda dikkat edilmesi gerektiğini ve bu çalışmanın yapılacak diğer çalışmalara referans olacağını düşünmekteyiz.

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Section: Discussionsupporting

confidence: 52%

Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses

et al. 2020

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“…IL-10 is usually considered to be an anti-inflammatory cytokine which can inhibit the production and response of pro-inflammatory cytokines in innate and adaptive immunity. However, APAP-induced liver injury could also lead to an abnormal increase in IL-10 content because the production of IL-10 was related to the time and degree of liver injury [36].…”

Section: Discussionmentioning

confidence: 99%

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Hao

Chen

et al. 2022

Nutrients

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Liver injury caused by an overdose of acetaminophen (APAP) is a major public health problem. This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver’s detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP—induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.

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“…People are urgent to find more alternative active ingredients in our daily food and health care products, and sanghuang polysaccharides are in line with this (Aida et al, 2009 ; Yang M. Y. et al, 2019 ; Li N. Y. et al, 2021 ; Martinez-Medina et al, 2021 ; Yadav and Negi, 2021 ). Innumerable works, in vitro and in vivo , have been implemented to substantiate that the sanghuang polysaccharides have multiple biological activities and health benefits, such as antioxidant and anti-aging (Wang et al, 2014a ; Yuan et al, 2018 ; Zuo et al, 2021 ), anti-tumor and immunomodulatory (Chen et al, 2011 ; Liu et al, 2018 ; Wan et al, 2020 ), anti-inflammatory and anti-nociceptive (Li et al, 2015 ; Wang et al, 2019 ; Sun et al, 2021 ), anti-diabetic (Kim et al, 2010 ; Wu et al, 2016 ; Khursheed et al, 2020 ), anti-microbial (Lee S. M. et al, 2010 ; Reis et al, 2014 ), anti-fatigue (Zhong, 2020 ), hepatoprotective (Liu et al, 2019b ; Zhang et al, 2019 ; Chen C. et al, 2020 ), neuroprotective (Liu Y. H. et al, 2015 ; Yang P. et al, 2019 ) activities, etc. Even though the bioactivities of sanghuang polysaccharides are intensively mined, scientific research focusing on deciphering the structure-bioactivity relationships and underlying mechanisms is still relatively insufficient.…”

Section: Physicochemical and Structural Propertiesmentioning

confidence: 99%

“…Compared with the untreated groups, the P. linteus polysaccharide treatment harbored a notable reduction in liver fibrosis in a thioacetamide-induced liver damage mice model via regulation of the oxidative stress pathways, heat shock pathways, and metabolic pathways, referring to a total of 13 differentially expressed proteins, including actin, tubulin α-1C chain, preprohaptoglobin, hemopexin, galectin-5, glutathione S-transferase α4, branched chain keto acid dehydrogenase heterotetrameric E1 subunit-α, glutathione S-transferase κ, glyceraldehyde-3-phosphate dehydrogenase, thiosulfate sulfurtransferase, betaine-homocysteine S-methyltransferase 1, quinoid dihydropteridine reductase, and ribonuclease UK114 (Wang H. L. et al, 2012 ). Chen C. et al ( 2020 ) evaluated the hepatoprotective effect of an isolated P. linteus polysaccharide against the acetaminophen-stimulated liver injury in mice, which was attributed to its antioxidant functions, by decreasing cytochrome P450 2E1 expression and hepatic release of cytokines, improving the levels of phase II enzymes, exhibiting hepatic-repairing performance, and accelerating metabolism of acetaminophen.…”

Section: Physicochemical and Structural Propertiesmentioning

confidence: 99%

Current advances and potential trends of the polysaccharides derived from medicinal mushrooms sanghuang

Wang

Zhou

et al. 2022

Front. Microbiol.

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For thousands of years, sanghuang is distinctive as a general designation for a group of precious and rare Chinese medicinal mushrooms. Numerous investigations have revealed that polysaccharide is one of the important biological active ingredients of sanghuang with various excellent biological activities, including antioxidant, anti-aging, anti-tumor, immunomodulatory, anti-inflammatory, anti-diabetic, hepatoprotective, and anti-microbial functionalities. For the past two decades, preparation, structural characterization, and reliable bioactivities of the polysaccharides from fruiting bodies, cultured mycelia, and fermentation broth of sanghuang have been arousing extensive interest, and particularly, different strains, sources, and isolation protocols might result in obvious discrepancies in structural features and bioactivities. Therefore, this review summarizes the recent reports on preparation strategies, structural features, bioactivities, and structure-activity relationships of sanghuang polysaccharides, which will enrich the knowledge on the values of natural sanghuang polysaccharides and support their further development and utilization as therapeutic agents, vaccines, and functional foods in tonic and clinical treatment.

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Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury in mouse

Cited by 26 publications

References 27 publications

Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses

Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Current advances and potential trends of the polysaccharides derived from medicinal mushrooms sanghuang

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