Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Panovska, Tatjana Kadifkova; Kulevanova, S.; Gjorgoski, Icko; Богданова, М.; Petrushevska, Gordana

doi:10.2478/v10007-007-0020-x

Cited by 46 publications

(33 citation statements)

References 12 publications

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“…48 Benefits were comparable to those seen with silymarin, the hepatoprotective flavonolignan extract from milk thistle. Separate research supports that golden germander can act as an inflammation modulator.…”

Section: Teucrium: Hepatotoxic or Hepatoprotective?supporting

confidence: 55%

Herbal Medicine and Nonalcoholic Fatty Liver Disease

Yarnell

Abascal

2010

Alternative and Complementary Therapies

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Nonalcoholic fatty liver disease (NAFLD; previously called "fatty liver") is a spectrum of conditions that are extremely common, in fact, believed to be the most common cause of elevated serum liver transaminases in adults in the United States. Although research is preliminary, there are ample suggestions that medicinal plants, through their insulin sensitizing and liver protective effects, may speed healing of the liver and prevent NAFLD from occurring in the first place.

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Section: Teucrium: Hepatotoxic or Hepatoprotective?supporting

confidence: 55%

Herbal Medicine and Nonalcoholic Fatty Liver Disease

Yarnell

Abascal

2010

Alternative and Complementary Therapies

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“…The livers of rats treated with T. oliverianum extract exhibited an almost normal architecture, with the presence of double nucleus hepatocytes, except for a slight deformity of hepatocytes with pyknosis and clearing of cytoplasm. These histological findings asserted the hepatoprotective and anticancer efficacy of T. oliverianum (Panovska et al, 2007). Photomicrograph of liver tissue section of rat in HCC group treated with R. stricta extract showed focal of anaplastic hepatocytes associated with congestion in the portal vein.…”

Section: Discussionmentioning

confidence: 63%

Biochemical and histological evidences for the antitumor potential of <i>Teucrium Oliverianum</i> and <i>Rhazya stricta</i> in chemically-induced hepatocellular carcinoma

Shahat¹,

Alsaid²,

Kotob³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Teucrium oliverianum and Rhazya stricta are medicinal plants used in traditional and herbal medicine for the treatment of diabetes, liver diseases and inflammatory conditions. The present study was planned to investigate the antitumor efficacy of Teucrium oliverianum and Rhazya stricta in chemically-induced hepatocellular carcinoma (HCC) in rats. Materials and Methods: Forty adult male rats weighing 170-200 g were divided into four groups; each group was comprised of ten rats: (1): Normal healthy animals served as negative control group, (2): Hepatocellular carcinoma (HCC) group in which the rats were orally administered Nnitrosodiethylamine (dissolved in 0.9% normal saline), in a dose of 20 mg/kg b.wt. five times a week for six weeks, (3): HCC group treated with Teucrium oliverianum extract in a dose of 600 mg/kg b.wt for two months and (4): HCC group treated with Rhazya stricta extract in a dose of 750 mg/kg b.wt for two months. Serum alanine aminotransferase (ALT), asparatate aminotransferase (AST), alkaline phosphatase (ALP) and gammaglutamyl transferase (γ-GT) activities were estimated. Serum carcinoembyronic antigen (CEA), alpha-fetoprotein (AFP), alpha-L-fucosidase (AFU), glypican-3 (GPC-3), golgi protein 73 (Gp-73) and vascular endothelial growth factor (VEGF) levels were determined. Histopathological examination of liver tissue sections was also carried out. Results: The HCC group showed significant elevation in serum AST, ALT, ALP and γ-GT activities as well as CEA, AFP, AFU, Gpc-3, Gp 73 and VEGF levels versus the negative control group. Photomicrograph of liver tissue sections of rats in HCC revealed hepatic parenchyma with foci of anaplastic hepatocellular carcinoma as well as other foci of cystic cholangio carcinoma associated with areas of telangictasis with haemorrhage as well as individual hepatocellular necrosis. Conclusion: Treatment of HCC groups with Teucrium oliverianum or Rhazya stricta extract experienced significant improvement in the measured biochemical parameters as well as in the structural organization of the liver. In conclusion, the current study provided experimental evidences for the antitumor efficacy of Teucrium oliverianum and Rhazya stricta against hepatocellular carcinoma. Such effect could be attributed to hepatoprotective properties, antiproliferative activity and antiangiogenic potential.

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“…Medicinal properties of various species of Teucrium are reported in literature showing antioxidant, antibacterial, antifungal activities [3-7]. Teucrium polium has been reported to possess antispasmodic, antimicrobial, anti-inflammatory, [8], hepatoprotective effect, [9] and analgesic properties [10]. While Teucrium chamaedrys has been used as antimalarial, antispasmodic and for gastric pain, kidney disorders, heart diseases etc [11,12].…”

Section: Introductionmentioning

confidence: 99%

Analysis of chemical constituents and antinociceptive potential of essential oil of Teucrium Stocksianum bioss collected from the North West of Pakistan

Shah

Ullah

Shah

et al. 2012

BMC Complement Altern Med

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BackgroundMedicinal plants are used for the treatment of different diseases in almost all cultures. Teucrium species grow wildly at different geographical locations around the world. Teucrium stocksianum is used in folk medicine for the treatment of diarrhea, cough, jaundice and abdominal pain. Scientific study on Teucrium stocksianum shows that it possesses anthelmintic, cytotoxic and antispasmodic activity. The aim of our present study is to identify the chemical composition and antinociceptive potential of the essential oil extracted from Teucrium stocksianum bioss.MethodEssential oil (EO) from the aerial parts of Teucrium stocksianum were extracted by hydrodistillation process. The qualitative and quantitative composition of essential oil was determined with Gas chromatography/Mass spectrometer. Antinociceptive activity was determined by acetic acid induced writhing method. Percent inhibition of writhes of the test concentration was determined by comparing it with that of control. Tween-80 emulsion 2.5% (5 ml/kg b.w) was used as a control while Diclofenic sodium 50 mg/kg (b.w) was used as a standard drug.ResultsThe chromatogram of the essential oil of Teucrium stocksianum shows differences both qualitatively and quantatively from essential oil composition reported in other countries. Hydrodistillation of Teucrium stocksianum yielded 0.4% (v/w), pale yellowish oil on dry basis. A total of 26 chemicals were identified by GC-MS accounting for 90.28% of the oil. The major components of essential oil were δ-cadinene (12.92%), α-pinene (10.3%), myrcene (8.64%), β-caryophyllene (8.23%), germacrene D (5.18%) and limonene (2.36%). Essential oil of Teucrium stocksianum has shown outstanding antinociceptive activity. It has been observed that increase in percent writhe inhibition (PWI) occurred from 20-80 mg/kg (b.w) and maximum writhe inhibition has been noted at a concentration of 80 mg/kg (b.w), but PWI decreased at 160 mg/kg, which may be due to some toxic effect of higher dose. ED50 value for Teucrium stocksianum was calculated as 31.5 ± 1.72415 mg/kg (b.w).ConclusionOur results indicate that there is a lot of variation in the composition of essential oil of Teucrium stocksianum boiss, which may be due to different climatic and experimental conditions. Secondly, the essential oil possesses strong antinociceptive activity and could be used in analgesic preparations especially for topical use.

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Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Cited by 46 publications

References 12 publications

Herbal Medicine and Nonalcoholic Fatty Liver Disease

Herbal Medicine and Nonalcoholic Fatty Liver Disease

Biochemical and histological evidences for the antitumor potential of <i>Teucrium Oliverianum</i> and <i>Rhazya stricta</i> in chemically-induced hepatocellular carcinoma

Analysis of chemical constituents and antinociceptive potential of essential oil of Teucrium Stocksianum bioss collected from the North West of Pakistan

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