Hepatoprotective Effect of Thymol on Chemical-induced Hepatotoxicity in Rodents

Janbaz, Khalid Hussain; Saeed, Sheikh A.; Gilani, A.H.

doi:10.3923/pjbs.2003.448.451

Cited by 16 publications

(2 citation statements)

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“…These results are in concurrence with Grespan et al [36]. In addition, thymol treatment rescued hepatocellular damage as evidenced by prevention of any increase in serum ALP, AST, or ALT activities [88]. Likewise, treating rats with thyme extract markedly reduced the elevated activities of ALT, AST, and ALP and the elevated level of total bilirubin in serum towards normal values, reflecting its efficacy for protecting against liver damage and demonstrating membrane stabilizing activity [89,90].…”

Section: Discussionsupporting

confidence: 84%

Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress

Ahmed

Galaly

Mostafa

et al. 2022

Oxidative Medicine and Cellular Longevity

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Doxorubicin (DOX) is an effective anticancer agent with a wide spectrum of activities. However, it has many adverse effects on various organs especially on the liver. Thymol, one of the major components of thyme oil, has biological properties that include anti-inflammatory and antioxidant activities. Thus, this study was designed to examine thyme oil and thymol for their ability to prevent doxorubicin-induced hepatotoxicity in Wistar rats. Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2 mg/kg bw/week, for seven weeks. Doxorubicin-injected rats were supplemented with thyme oil and thymol at doses 250 and 100 mg/kg bw, respectively, four times/week by oral gavage for the same period. Treatment of rats with thyme oil and thymol reversed the high serum activities of AST, ALT, and ALP and total bilirubin, AFP, and CA19.9 levels, caused by doxorubicin. Thyme oil and thymol also reduced the high levels of TNF-α and the decreased levels of both albumin and IL-4. These agents ameliorated doxorubicin-induced elevation in hepatic lipid peroxidation and associated reduction in GSH content and GST and GPx activities. Further, the supplementation with thyme oil and thymol significantly augmented mRNA expression of the level of antiapoptotic protein Bcl-2 and significantly downregulated nuclear and cytoplasmic levels of the hepatic apoptotic mediator p53. Thus, thyme oil and thymol successfully counteracted doxorubicin-induced experimental hepatotoxicity via their anti-inflammatory, antioxidant, and antiapoptotic properties.

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Section: Discussionsupporting

confidence: 84%

Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress

Ahmed

Galaly

Mostafa

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…The extract exhibited a positive hepatoprotective activity by decreasing the levels of biochemical parameters assessed, like serum AST, ALT and ALP [33]. Janbaz et al investigated hepatoprotective activity of thymol against paracetamol and carbon tetrachloride induced hepatic damage in rodents [37]. Velanganni and Balasundaram examined protective effect of vitamin A, ascorbic acid and alpha-tocopherol on 2, 4-dimethyl amino azo-benzene induced hepatoma in rats.…”

Section: Hepatoprotection Against Chemicalsmentioning

confidence: 99%

Multiple approach of natural hepato-protectant against chemical toxicity

Mahour¹

2022

World J. Bio. Pharm. Health Sci.

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Plants are the major source of various ingredients which are responsible for the treatment of diseases and complications. They are used from ancient times mentioned in the Ayurveda and various Vedas because herbal medicine and their products are safe, very effective and environmental eco-friendly. They are less toxic and easily available. On the other hand, liver is the major vital organ performing major functions in the body like detoxification, biotransformation etc. It synthesizes proteins and produces biochemical’s necessary for digestion and growth. Its other roles in metabolism include the regulation of glycogen storage, decomposition of red blood cells and the production of hormones. In spite of this environment pollutants or toxicants accumulate in the liver and causes ill effects on liver. They change the architecture of hepatocytes and diminished the functions of liver due to this reason metabolism of the body changes. Hence there is urgent need to some liver tonic. Considering all these facts present review article explored the natural hepatoprotectant against chemical toxicity.

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Coriander (Coriandrum sativum L.): A Potential Source of High‐Value Components for Functional Foods and Nutraceuticals‐ A Review

Sahib

Anwar

Gilani

et al. 2012

Phytotherapy Research

232

152

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Coriander (Coriandrum sativum L.), a herbal plant, belonging to the family Apiceae, is valued for its culinary and medicinal uses. All parts of this herb are in use as flavoring agent and/or as traditional remedies for the treatment of different disorders in the folk medicine systems of different civilizations. The plant is a potential source of lipids (rich in petroselinic acid) and an essential oil (high in linalool) isolated from the seeds and the aerial parts. Due to the presence of a multitude of bioactives, a wide array of pharmacological activities have been ascribed to different parts of this herb, which include anti-microbial, anti-oxidant, anti-diabetic, anxiolytic, anti-epileptic, anti-depressant, anti-mutagenic, anti-inflammatory, anti-dyslipidemic, anti-hypertensive, neuro-protective and diuretic. Interestingly, coriander also possessed lead-detoxifying potential. This review focuses on the medicinal uses, detailed phytochemistry, and the biological activities of this valuable herb to explore its potential uses as a functional food for the nutraceutical industry.

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Hepatoprotective Effect of Thymol on Chemical-induced Hepatotoxicity in Rodents

Cited by 16 publications

References 1 publication

Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress

Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress

Multiple approach of natural hepato-protectant against chemical toxicity

Coriander (Coriandrum sativum L.): A Potential Source of High‐Value Components for Functional Foods and Nutraceuticals‐ A Review

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