2022
DOI: 10.1155/2022/1449286
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Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Abstract: Cordia africana Lam (Boraginaceae) is widely used in Ethiopian folk medicine for the treatment of different types of liver disorders. Thus, this study aimed to investigate the hepatoprotective effects of an aqueous (CAAE), 80% methanol extracts of C. africana stem bark (CAME), and the solvent fractions of the methanol extract against acetaminophen (APAP)-induced liver injury in rats. Acute toxicity test and APAP-induced lethality test were done on mice of either sex, while APAP dose selection test was done on … Show more

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Cited by 11 publications
(4 citation statements)
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“…The coarse powder (600 g) of Datura stramonium leaves was macerated in 80% methanol (1:7 leaves powder to solvent ratio) for 72 hours with mechanical shaking frequently. 15 This was repeated 3 times until the extract gave discoloration. Then the plant material was filtered with gauze and then by filter paper.…”
Section: Methodsmentioning
confidence: 99%
“…The coarse powder (600 g) of Datura stramonium leaves was macerated in 80% methanol (1:7 leaves powder to solvent ratio) for 72 hours with mechanical shaking frequently. 15 This was repeated 3 times until the extract gave discoloration. Then the plant material was filtered with gauze and then by filter paper.…”
Section: Methodsmentioning
confidence: 99%
“…The plant material was coarsely grounded into powder using a mortar and pestle. The coarse powder (600 g) of Datura stramonium leaves was macerated in 80% methanol (1:7 leaves powder to solvent ratio) for 72 hours with mechanical shaking frequently (15). This was repeated 3 times until the extract gave discoloration.…”
Section: Preparation Of Crude Extractmentioning
confidence: 99%
“…On first day, all the groups were treated with the drug and doses assigned to them and finally, after two hours received thioacetamide. On the second day, assigned doses were repeated along with Pentobarbitone sodium 40mg/kg i.p.loss of righting reflex was noted 10,11,12,13 .…”
Section: Assessment Of Hepatoprotective Activitymentioning
confidence: 99%