Hepatoprotective effects of parsley (Petroselinum Crispum) extract in rats with bile duct ligation

Ede, Seren; Özbeyli, Dilek; Erdoğan, Ömer; Çevik, Özge; Kanpalta, Fatma; Ercan, Feríha; Yanardağ, Refiye; Saçan, Özlem; Ertik, Onur; Yüksel, Meral; Şener, Göksel

doi:10.1016/j.ajg.2022.10.006

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…P. crispum Mill. was found to possess many pharmacological effects, including antioxidant, antibacterial, antifungal, hepatoprotective, antidiabetic, analgesic, antispasmodic, immunosuppressive, and gastroprotective properties [19][20][21][22][23][24][25][26][27][28]. The results of previous studies highlighted the presence of certain phenolic compounds, mainly ferulic acid, gallic acid, and quercetin.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Ganea,

Vicaș,

Gligor

et al. 2024

Molecules

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The status of parsley as a well-known folk medicine noted for its nutritional and medicinal properties prompted the exploration of its potential as a functional food and natural remedy. The paper aims to investigate the potential of parsley to enhance muscle function and alleviate psoriasiform dermatitis, eventually establishing it as a natural, well-tolerated alternative with specific benefits for both muscles and skin. This study examines the tolerability of parsley in a cohort of 937 participants by assessing immunoglobulin G (IgG) reactions. The findings reveal high tolerability, as 96.26% of participants experienced no adverse effects. Among the 902 individuals lacking hypersensitivity, 37.02% reported muscle cramps, with a notable 15.02% reduction observed in the subgroup consuming parsley juice. In the subset of 32 subjects with dermatitis, the application of parsley extract ointment led to a significant decrease in dermatological parameters (redness, thickness, scaling). While the control group exhibited improvements, statistical significance was not observed. Notably, four categories of affected area reduction were identified, with scaling demonstrating the most pronounced impact. The results propose that parsley holds promise for favorable tolerability, contributing to the alleviation of muscle cramps and presenting an effective alternative in dermatitis treatment. Nonetheless, sustained validation through long-term studies is imperative to substantiate these preliminary findings.

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Section: Discussionmentioning

confidence: 99%

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Ganea,

Vicaș,

Gligor

et al. 2024

Molecules

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“…36 The same dose of parsley leaf also showed therapeutic effects on the bile duct ligation-induced liver damage via prevention of liver fibrosis, which was evident from the reduction of liver damage biomarkers such as hydroxyproline and transforming growth factor (TGF)-β, DNA damage marker 8-hydroxy guanosine, and caspase-3 as an apoptosis marker. 37 In a study on highfructose-induced hepatic steatosis using the same treatment regimen with parsley leaf ethanolic extract, a remarkable decrease in hepatic inflammation and fibrosis was observed in histopathological evaluations. Along with a significant decrease in body weight, modulations were noted on hepatic enzymes and parameters of lipid profile including low-density lipoprotein cholesterol (LDL), triacylglycerol (TAG), and highdensity lipoprotein cholesterol (HDL).…”

Section: ■ Indigenous Traditional Knowledgementioning

confidence: 98%

“…Additionally, a significant improvement was observed in glycemic and lipid profile, as well as serum albumin and total protein . The same dose of parsley leaf also showed therapeutic effects on the bile duct ligation-induced liver damage via prevention of liver fibrosis, which was evident from the reduction of liver damage biomarkers such as hydroxyproline and transforming growth factor (TGF)-β, DNA damage marker 8-hydroxy guanosine, and caspase-3 as an apoptosis marker . In a study on high-fructose-induced hepatic steatosis using the same treatment regimen with parsley leaf ethanolic extract, a remarkable decrease in hepatic inflammation and fibrosis was observed in histopathological evaluations.…”

Section: Chemistry Of Parsleymentioning

confidence: 99%

Petroselinum crispum (Mill.) Fuss (Parsley): An Updated Review of the Traditional Uses, Phytochemistry, and Pharmacology

Bahramsoltani,

Ahmadian,

Daglia

et al. 2024

J. Agric. Food Chem.

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Petroselinum crispum (Mill.) Fuss (parsley) is a popular medicinal plant widely used in different traditional medicines all over the world. This paper provides an updated review on the traditional use, phytochemistry, and pharmacological activities of parsley. Parsley contains volatile compounds such as terpenes and terpenoids in the essential oil, as well as phenolic compounds in the plant extract. Parsley is traditionally used as a diuretic, liver and stomach tonic, and for urolithiasis and indigestion. Pharmacological investigations also confirm several biological activities of parsley including hepatoprotective, nephroprotective, antiurolithiatic, neuroprotective, cardioprotective, and antineoplastic effects in animal and cell-based studies. Parsley has currently demonstrated several pharmacological activities in preclinical studies; however, there is a big lack in clinical evidence. Considering parsley as a possible valuable medicinal food, future clinical trials are recommended to evaluate the clinical efficacy and safety of the plant in different health conditions.

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“…It has been determined that the extract reduces increased ALT, AST and bilirubin levels and improves oxidative damage parameters. It has been shown that P. crispum extract is protective against bile obstruction-induced hepatic damage and fibrosis in rats owing to its antioxidant and antiinflammatory effects [74].…”

Section: Antihepatotoxic Activitymentioning

confidence: 99%

Petroselinum Crispum (Mill.) Fuss (Parsley), a Food and Medicinally Important Plant: A Review of Recent Studies Between 2013-2023

Subaş,

Özgen,

Gökkaya

et al. 2024

Ankara Ecz. Fak. Derg.

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Objective: Petroselinum crispum (Mill.) Fuss is a bright green biennial medicinal and aromatic herb that grows almost all over the world. Today, it is one of the most commonly used culinary herbs. In addition to its use as food, it has been shown to possess broad pharmacological activities in several in vivo and in vitro studies. This study aimed to comprehensively summarize the current studies on the traditional use, phytochemical composition, pharmacological activities, clinical studies, toxicity, and drug interactions of parsley. Result and Discussion: According to the literature data, parsley is used as a diuretic, carminative, emmenagogue and for the prevention and treatment of kidney stone formation, the treatment of conditions such as urinary tract infections and stomach disorders. Its phytochemical composition consists of flavonoids, coumarins, phenolic compounds, organic acids, carotenoids, vitamins, minerals, fixed oil, essential oil, and other compounds. Studies on P. crispum have shown that it has a wide range of pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antihypertensive, antiplatelet, analgesic, antiinflammatory, antihepatotoxic, antinephrotoxic, anticancer, antiurolithiatic, wound healing, antiobesity, estrogenic and neuroprotective effects. This review comprehensively summarizes the scientific data of the last ten years (2013-2023) on P. crispum.

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Hepatoprotective effects of parsley (Petroselinum Crispum) extract in rats with bile duct ligation

Cited by 4 publications

References 24 publications

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis

Petroselinum crispum (Mill.) Fuss (Parsley): An Updated Review of the Traditional Uses, Phytochemistry, and Pharmacology

Petroselinum Crispum (Mill.) Fuss (Parsley), a Food and Medicinally Important Plant: A Review of Recent Studies Between 2013-2023

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