Hepatoprotective Effects of Phloridzin on Hepatic Fibrosis Induced by Carbon Tetrachloride against Oxidative Stress-Triggered Damage and Fibrosis in Rats

Deng, Gai-Gai; Wang, Junzhi; Zhang, Qiaoyin; He, Hui; Wu, Fangfang; Feng, Tao; Zhou, Ji-Gang; Zou, Kun; Hattori, Masao

doi:10.1248/bpb.b12-00057

Cited by 37 publications

(29 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have suggested that fibrotic development can be controlled or inhibited through clinically therapeutic regimes [21]. In addition, plant-isolated active components, such as phloridzin [22], triterpenoid saponin [23] and puerarin [24], exert an effective antifibrotic role. Our data showed that body weight loss and hepatomegalia occurred in CCl 4 -injured rats, indicating that the signs of malnourishment were due to CCl 4 -induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Our previous studies have shown that plumbagin effectively inhibits hepatic stellate cell (HSC) proliferation. Thus, plumbagin-mediated anti-fibrotic effects in vivo merit further investigation. Methods: We used rat models to assess the potential benefits of plumbagin against CCl₄-induced liver fibrosis. Results: The results showed that plumbagin lowered the serum concentrations of liver functional enzymes (ALT, AST, ALB, TBIL) in CCl₄-fibrotic rats while reducing inflammatory cytokine levels (IL-6, TNF-a). As reflected in pathological examinations, rats that were administered plumbagin showed decreased collagen markers (HA, LN, PCIII and CIV) in liver tissues and improved hepatocellular impairments. In addition, plumbagin contributed to down-regulating NF-κB and TLR-4 mRNA in CCl₄-lesioned livers. As revealed in the immunohistochemical assay, plumbagin-administered rats showed reduced levels of a-SMA and TNF-a immunoreactive cells in liver tissue. Conclusion: Collectively, these findings offer appealing evidence that plumbagin may serve as an anti-fibrotic medication through inactivating the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Significant differences were observed relative to the normal group at p50.01 (**) and from the RU486 group at p50.05 (#) and p50.01 (##). (Deng et al, 2012) and anti-bacterial effects (Muthuswamy & Rupasinghe, 2007). In this study, we found that phloridzin was effective in improving LPL activity and TG metabolism in stressloaded mice.…”

Section: Discussionmentioning

confidence: 99%

Phloridzin improves lipoprotein lipase activity in stress-loaded miceviaAMPK phosphorylation

Wang

et al. 2014

International Journal of Food Sciences and Nutrition

View full text Add to dashboard Cite

Long-term stress exposure can lead to disturbed homeostasis and cause many life-style diseases. Phloridzin possesses various bioactivities, but the understanding of the effects of phloridzin on stress-related lipid metabolism disorder is limited. Our results demonstrate that phloridzin improved plasma lipoprotein lipase (LPL) activity and triglyceride metabolism in restrained mice. A decrease of angiopoietin-like protein 4 (ANGPTL4) mRNA expression and an increase of AMP-activated protein kinase (AMPK) phosphorylation were observed after phloridzin treatment. After inhibiting AMPK phosphorylation, the effects of phloridzin on the amelioration of plasma LPL activity and suppression of ANGPTL4 expression were blocked. In addition, cardiac AMPK phosphorylation, plasma LPL activity and ANGPTL4 expression were also affected by phloridzin, even if the glucocorticoid receptor was blocked. Taken together, the down-regulation of ANGPTL4 expression by phloridzin was probably via a direct activation of AMPK pathway. This discovery can provide a biochemical and nutritional basis for the use of phloridzin-containing food and beverage in daily life.

show abstract

“…Polyphenol-rich green tea and its principal constituent EGCG were found to ameliorate oxidative stress in various studies [160, 161]. Other polyphenols such as puerarin [162], baicalin [163], and phloridzin [136] also attenuated oxidative stress in various disease models. Apart from in vitro and in vivo evidence, sufficient clinical evidence also suggests the antioxidant potential of polyphenols.…”

Section: Polyphenols and Oxidative Stressmentioning

confidence: 99%

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Bhullar

Rupasinghe

2013

Oxidative Medicine and Cellular Longevity

350

194

View full text Add to dashboard Cite

Aging leads to numerous transitions in brain physiology including synaptic dysfunction and disturbances in cognition and memory. With a few clinically relevant drugs, a substantial portion of aging population at risk for age-related neurodegenerative disorders require nutritional intervention. Dietary intake of polyphenols is known to attenuate oxidative stress and reduce the risk for related neurodegenerative diseases such as Alzheimer's disease (AD), stroke, multiple sclerosis (MS), Parkinson's disease (PD), and Huntington's disease (HD). Polyphenols exhibit strong potential to address the etiology of neurological disorders as they attenuate their complex physiology by modulating several therapeutic targets at once. Firstly, we review the advances in the therapeutic role of polyphenols in cell and animal models of AD, PD, MS, and HD and activation of drug targets for controlling pathological manifestations. Secondly, we present principle pathways in which polyphenol intake translates into therapeutic outcomes. In particular, signaling pathways like PPAR, Nrf2, STAT, HIF, and MAPK along with modulation of immune response by polyphenols are discussed. Although current polyphenol researches have limited impact on clinical practice, they have strong evidence and testable hypothesis to contribute clinical advances and drug discovery towards age-related neurological disorders.

show abstract

Hepatoprotective Effects of Phloridzin on Hepatic Fibrosis Induced by Carbon Tetrachloride against Oxidative Stress-Triggered Damage and Fibrosis in Rats

Cited by 37 publications

References 32 publications

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Phloridzin improves lipoprotein lipase activity in stress-loaded miceviaAMPK phosphorylation

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Contact Info

Product

Resources

About