Hepatoprotective effects of sericin on aging-induced liver damage in mice

Bagheri, Yasin; Sadigh-Eteghad, Saeed; Fathi, Ezzatollah; Mahmoudi, Javad; Abdollahpour, Abdollah; Namini, Nasim Jalili; Malekinejad, Zahra; Mokhtari, Kiarash; Barati, Alireza; Montazersaheb, Soheila

doi:10.1007/s00210-021-02160-9

Cited by 5 publications

(3 citation statements)

References 61 publications

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“…The SD mice as well as the MSD‐treated group showed the disappearance of most of the previous histological alterations caused by DEN to be more or less similar to that of the control group except for some cellular diffuse degeneration. These results are in line with previous findings 6,14,44,45 . Interestingly, SS is capable alone to bring the liver tissue to its normal appearance.…”

Section: Discussionsupporting

confidence: 93%

“…These results are in line with previous findings. 6,14,44,45 Interestingly, SS is capable alone to bring the liver tissue to its normal appearance. ki67, a proliferative marker used routinely in the pathologic evaluation for all cancers, 46 showed a pattern characterized by increasing Ki67 expression in the liver from DEN-induced mice.…”

Section: Immunohistochemical Assessmentmentioning

confidence: 99%

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Promising growth inhibitory potential of extracted natural silk sericin biopolymer against DEN‐induced liver tumor in male mice

Bakr,

Sadek,

El‐Samad

et al. 2024

J of Applied Polymer Sci

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Silk sericin (SS), a protein biopolymer, is gaining an increasing attention in a variety of biomedical applications. Our objective was to identify the optimal extraction method yielding the highest silk protein content, to assess its chemical elemental composition, to characterize it, and to compare its conformation by X‐ray diffraction and Fourier‐transform infrared versus that of the commercial one. Herein, alkali and high temperature is the perfect approach. This study aimed further to test whether extracted SS could attenuate the adverse hepatotoxic effects induced by diethylnitrosamine (DEN) in mice. Animals were injected intraperitoneally once weekly for four consecutive weeks with physiological saline (0.9% NaCl), DEN (25 mg/kg), SS (1 g/kg) 90 min prior to DEN injection, melatonin (10 mg/kg) followed within 1 h with the administration of SS and 30 min later with DEN. The results confirmed the hepatotoxicity of DEN manifested by an increase in liver enzymes' activity, and pathological changes in the liver tissue. The combined use of SS and/or melatonin with DEN returned most of the parameters to values similar to the controls. Briefly, chemically characterized SS seems a valuable extract for further consideration as anti‐carcinogenic agent. It has the potential to upgrade liver cancer chemotherapeutic agents.

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Section: Discussionsupporting

confidence: 93%

Section: Immunohistochemical Assessmentmentioning

confidence: 99%

Promising growth inhibitory potential of extracted natural silk sericin biopolymer against DEN‐induced liver tumor in male mice

Bakr,

Sadek,

El‐Samad

et al. 2024

J of Applied Polymer Sci

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“…Understanding the causes and mechanisms of these remote effects is necessary to investigate the preventive and therapeutic pathways [9,10]. Accordingly, different preventive and therapeutic approaches have been investigated to decrease kidney I/R-induced injury in distant organs [11,12].…”

Section: Introductionmentioning

confidence: 99%

Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats

et al. 2023

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Acute kidney injury (AKI) is a common subsequent problem after many medical conditions. AKI is associated with distant organ dysfunction where systemic inflammation and oxidative stress play major roles. In this study, the effect of Prazosin, an α1-Adrenergic receptor antagonist, was investigated on the liver injury induced by kidney ischemia-reperfusion (I/R) in rats. Male adult Wistar rats (n=21) were divided into three groups: sham, kidney I/R, and kidney I/R pre-treated with Prazosin (1 mg/kg). Kidney I/R was induced by vascular clamping of the left kidney for 45 min to reduce the blood flow. Oxidative and antioxidant factors along with apoptotic (Bax, Bcl-2, caspase3), and inflammatory (NF-κβ, IL-1β, and IL-6) factors were measured in the liver at protein levels. Prazosin could reserve liver function (p<0.01) and increase glutathione level (p<0.05) after kidney I/R significantly. Malonil dialdehyde (MDA), a lipid peroxidation marker, was diminished more significantly in Prazosin-treated rats compared to the kidney I/R group (p<0.001). Inflammatory and apoptotic factors were diminished by Prazosin pre-treatment in the liver tissue (p<0.05). Pre-administration of Prazosin could preserve liver function and decrease its inflammatory and apoptotic factors under kidney I/R conditions.

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