Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-iduced oxidative damage in rats

Lin, Hsin-Fu; Tseng, Hsien-Chun; Wang, Chau‐Jong; Lin, Jin-Jin; Lo, Chia-Wen; Chou, Fen‐Pi

doi:10.1016/j.cbi.2007.08.008

Cited by 172 publications

(119 citation statements)

References 30 publications

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“…The surrounding CAM showed a few angiogenesis formation. However, in the control group, a number of angiogenesis were observed: S. nigrum could inhibit the angiogenesis on CAM 162 . Solanum nigrum L. (SN) is an herbal plant that has been used as hepatoprotective and anti-inflammatory agent in Chinese medicine.…”

Section: Issn: 0975-8232mentioning

confidence: 88%

Untitled

2012

IJPSR

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This article reviews, connected the gap between the folkloric use of Solanum nigrum and the results of evidence based experiments. Although Solanum nigrum is a rich source of one of plants most dreaded toxins solanine, it has appreciably monstrated its potential as a reservoir of antioxidants having hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory.effects. The review encompasses in-vitro, in vivo and clinical studies done on Solanum nigrum, while examining.whether or not correct scientific measures have been taken in generating experimental evidences for its traditional uses. This review would afford research scientist to know how much is known and what is left undone in the investigation of Solanum nigrum. The compounds considered in this revieware flavonoids and other phenolics, alkaloids (especially indole terpenoid and purine alkaloids), essential oils and other terpenoids, cannabinoids, lucosinolates and isothiocyanates, and compounds having human hormone activity. The review concludes with a discussion of the possible evolutionary mechanisms that have led to the evolution of UV-B regulation of secondary metabolite accumulation. Many Ayurveda philosophers and healers praised about the properties of this plant and utilized in various disorders. Here, a review made on the screening of Solanum nigrum for various activities. It is found that the drug is very potential and can be used for various applications as mentioned in Ayurveda. Black nightshade grows as a weed, found in the dry parts of India and other parts of the world. It has a medicinal usage and has been used as a traditional folk medicine for treating various ailments such as pain, fever and liver disorders. Generally, black nightshade is very rich in nutritive values, which are capable of supplying minerals, vitamins, hormones and proteins. This herb elaborates a wide variety of medicinal properties such as anticancer, antioxidant, neuroprotective, cytoprotective, antimicrobial, antinociceptive and antipyretic properties.

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Section: Issn: 0975-8232mentioning

confidence: 88%

Untitled

2012

IJPSR

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“…Thus, it can be concluded from the present study that S. nigrum aerial parts ethanolic extract has anti-oxidant activity as it neutralized the oxidant biomolecules involved in oxidative damage to lipid membranes. S. nigrum extract has been reported as a potent antioxidant against various diseases and oxidative stress induced degenerative processes [14,15]. This antioxidant potential of the extract is might be due to the presence of excess phenolic compounds like flavonoids, Vitamin C, steroids and β-carotene.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of ethanolic extract of Solanum nigrum for lipofundin-induced hyperlipidemia in Rabbits

Imran¹

2016

PAB

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Attenuation of hyperlipidemia with extract of medicinally important plant and reversal of lipid disorders is clinically very important. The aim of present study was to identify the therapeutic potential of Solanum nigrum ethanolic extract in lowering the cholesterol level in lipofundin treated hyperlipidimic rabbits in vivo. 20% lipofundin was used to induce hyperlipidmia in rabbits @ 2 ml/kg body weight through slow intravenous administration in the marginal ear vein for 7 days. For next 2 weeks the control group was placed at standard diet, whereas the test group was given the ethanolic crude extract of Solanum nigrum at the dose of 300 mg/kg body weight. On the completion of treatment blood samples were collected from both control and test groups and were analyzed for the lipid profile values. It was observed in the test group after treatment with ethanolic extract of S. nigrum, the raised level of serum total cholesterol, triglyceride, highdensity lipoprotein, low-density lipoprotein were decreased towards normal values. Thus the present study demonstrated that S. nigrum possessed significant anti-hyper lipidimic activity in lipofundin induced hyperlipidimic rabbits.

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“…For example, Solanum nigrum extract can protect liver against the CCl 4 -induced oxidative damage in rats, and has the antiviral potential against HCV, HBV and HIV [28][29][30].Ursolic acid extracted from Hedyotis diffusa Wild possesses hepatoprotective ability and can inhibit HBV replication by blocking the HBx [31].Saikosaponins, the main active constituents of Radix Bupleuri, have been shown to possess immunomodulatory, hepatoprotective, anti-tumor and anti-viral activities, and Saikosaponin c exhibits anti-HBV activity and Saikosaponin d possesses potent cytotoxicity against human hepatocellular carcinoma cells [32]. The extracts of Sedum sarmentosum showed strong hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes [33].…”

Section: Comparison Of Total Efficacy Of Drugs On Chbmentioning

confidence: 99%

Investigation of therapeutic effect of Longchai Formula Granule on chronic hepatitis B patients: A double-blind, controlled and randomized clinical trial

Yan

et al. 2017

BIO Web Conf.

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Abstract. Objective: To objectively evaluate the clinical efficacy of Longchai Formula Granule (LCFG) on chronic hepatitis B (CHB). Methods: According to GCP, 100 CHB patients who meet enter criterion were encoded and divided randomly into the test group (50 cases) and the control group (50 cases). The patients in test group were treated with LCFG and matrine capsule simulation agent, the patients in control group was treated with matrine capsule and LCFG simulation agent. Both groups have 12-week treatment period. The changes of Chinese medicine symptoms, ALT, AST, graduation of liver function, HBeAg, HBsAg, HBV-DNA in CHB patients were observed and compared. Results: After unblinding, statistical data showed that there were 82 effective actual CHB cases composed of 40 CHB patients in test group (10 cases dropout) and 42 CHB patients in control group (8 cases dropout). The total efficient of Chinese symptoms improvement and ALT in test group is better than the control group (P<0.05). The contents of AST, the graduation of liver function, HBeAg, HBsAg, and HBV-DNA in two groups were totally improved than before treatment, but there was no significant differences between groups (P>0.05). As a whole, it shows a tendency that the change of these values in test group induced by LCFG is better than these values in control group induced by matrine capsule. Conclusions: In summary, LCFG is effective for CHB patients and has no significant difference with matrine cpasules. However, LCFG is better than matrine capsule in the improvement of symptomatology and liver function.

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Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-iduced oxidative damage in rats

Cited by 172 publications

References 30 publications

Untitled

Untitled

Therapeutic potential of ethanolic extract of Solanum nigrum for lipofundin-induced hyperlipidemia in Rabbits

Investigation of therapeutic effect of Longchai Formula Granule on chronic hepatitis B patients: A double-blind, controlled and randomized clinical trial

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