Hepatoprotective Effects of Tribulus terrestris Hydro-Alcholic Extract on Non-Alcoholic Fatty Liver- Induced Rats

Almasi, Fatemeh; Khazaei, Mozafar; Chehrei, Shima; Ghanbari, Ali

doi:10.4067/s0717-95022017000100054

Cited by 11 publications

(14 citation statements)

References 15 publications

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“…Previous research demonstrated that N-acetylcysteine provided protection against hepatic fibrosis in cirrhotic rat liver (13). Studies also showed that T. terrestris (4) and Ashwagandha (9) were effective in combating fibrosis in models of hepatotoxicity.…”

Section: Discussionmentioning

confidence: 98%

“…They administered T. terrestris at a dose of 500 mg/kg for 6 days and showed a decrease in liver enzymes. In an experimental fatty liver model induced by a high fructose diet, Almasi et al (4) reported that administered at doses of 500, 700 and 1000 mg/kg for 5 weeks led to a decrease in liver enzymes and hepatosteatosis in accordance with an increase in the dose. Their study was published after our study was completed.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, this plant extract has anti-bacterial, antioxidant and anti-toxic activities (3). Given the hypolipidemic and antioxidant effects of T. terrestris, it is thought to have hepatoprotective properties (4). Previous research demonstrated that tribulusamide A and B compounds were protective in hepatocytes in D-galactosamine-induced toxicity (5).…”

mentioning

confidence: 99%

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Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

Altay¹,

Doğan²,

Orhan³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Fibrosis, which develops during the progression of liver damage, is the previous stage of cirrhosis. Carbon tetrachloride is one of the most commonly used hepatic toxins in experimental animal models of liver fibrosis. It was investigated the hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine in an experimental model of liver fibrosis induced by carbon tetrachloride in this study. Fifty Wistar rats were divided into five groups of 10 each, as follows: 1) Control, 2) Carbon tetrachloride, 3) Carbon tetrachloride plus N-acetylcysteine, 4) Carbon tetrachloride plus T. terrestris, and 5) Carbon tetrachloride plus Ashwagandha group. At the end of 6 weeks, the rats were sacrificed, and serum and tissue samples were collected. Aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, malondialdehyde, NF-κB, collagen 1, nuclear factor erythroid-2-related factor 2, tumor necrosis factor-α were analyzed, and histopathological evaluation was performed. There were no significant differences in serum aspartate aminotransferase and alanine aminotransferase levels of the N-acetylcysteine-treated group versus those in the T. terrestris-and Ashwagandha-treated groups (p > 0.05). Liver malondialdehyde levels were lower in the Nacetylcysteine-, T. terrestris-and Ashwagandha-treated groups than in the carbon tetrachloride-administered group (p < 0.001). There were differences between groups in NF-κB, collagen 1, nuclear factor erythroid-2related factor 2 and tumor necrosis factor-α levels (p < 0.05). In conclusion, T. terrestris, Ashwagandha and Nacetylcysteine had protective effects on the liver in this experimental fibrosis model. T. terrestris was a little more effective than Ashwagandha in combating liver fibrosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

Altay¹,

Doğan²,

Orhan³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…Its various parts contain a variety of medicinally important chemical constituents, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. The activity depends on the concentration and the composition of active saponins, which in turn is influenced by the geographical origin of plant material [1][2][3][4][5][6]. Since the levels of Na, Mg, K, Ca, and Zn in analyzed samples of T. terrestris are higher than the levels considered as reference, the importance of the contribution by T. terrestris in the daily human needs can be considered The Ca, Fe, Zn content of the tested raw materials of T. terrestris, although high, cannot be used to supplement the intake, since any plant sources that have a high content of bi-or tri-valent ions have a low bioavailability due to their content of phytic acid, polyphenols, and tannins, which drastically limits absorption.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Major and Trace Element Content of Tribulus terrestris L. Wildlife Plants

Tkachenko¹,

Frontasyeva

Vasilev

et al. 2020

Plants

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The genus Tribulus L. (Zygophyllaceae) includes 12 species, the most important of which is Tribulus terrestris L. This annual herb grows in temperate and tropical climates, and has a rich chemical composition of biologically active substances and chemical elements. Medicinal plants, and the phytopreparations obtained from them, are becoming more and more popular in world practice as they are used to successfully treat human diseases. Their therapeutic effect is due to the presence in them, of a variety of natural compounds and biologically important trace elements, especially in higher concentrations present in higher doses. T. terrestris is becoming more and more popular for the treatment of diseases of the human genital area and sexual dysfunctions. The elemental content in the tissues of leaf, flower, and fruit of T. terrestris was determined by using multi-element instrumental epithermal neutron activation analysis. For the first time, 26 essential and trace elements were observed in the plant species collected in Russia (from cultivated) and China (wild growing). It was confirmed that the elemental composition of T. terrestris grass varies depending on the habitat (geographic zones). The place of growth affects the accumulation of elements by the plant.

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