Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Bansal, Jharna; Kumar, Nitin; Malviya, Rishabha; Sharma, Pramod Kumar

doi:10.5530/pc.2014.3.2

Cited by 11 publications

(6 citation statements)

References 96 publications

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“…Besides this ejection of bile, the collection, as well as detoxification of various drugs and xenobiotics, proceeds through the liver. The hepatic reticuloendothelial system (RES) clears stimulated clotting factors, proteolytic enzyme/inhibitor complexes, and fibrin–fibrinogen cleavage proceeds (Bansal et al 2014 ). Liver-related diseases are one of the biggest health disorders in the world; the pathogenesis of hepatic ailments as well as the role of oxidative stress inflammation are well accomplished (Malhi and Gores 2008 ; Tacke et al 2009 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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“…Around 160 phyto constituents taken from 101 plant species have been proved to possess hepatoprotective activity ( Ali et al, 2019 ). Despite developments in modern medicine system, there are just a few effective natural medicines in the market that can be used to boost the liver function, protect the damage or help to regenerate hepatic cells ( Bansal et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Chenopodium album extract ameliorates carbon tetrachloride induced hepatotoxicity in rat model

Hussain

Asrar

Rasul

et al. 2022

Saudi Journal of Biological Sciences

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“…Phyllanthus niruri aids memory enhancement, help to reduce fatigue and possess anti-ageing and anti-stress properties [ 21 ]. Also, Aloe vera , Tephrosia purpurea and Eclipta alba have hepatoprotection, blood cleansing synergy and also help in managing gastrointestinal integrity and heart burn [ 22 ]. Eclipta alba , Aloe vera , Tephrosia purpurea and Phyllanthus niruri together offer hepatoprotection weight loss therapy.…”

Section: Introductionmentioning

confidence: 99%

Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats

Kale

Akinpelu

Bakare

et al. 2018

BMC Complement Altern Med

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BackgroundThis present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fructose feeding (20%W/V) ad libitum for 2 weeks and streptozotocin (STZ, 40 mg/kg) (15th Day) intraperitoneally.MethodsSeventy-two hours after STZ injection, fourty-eight diabetic rats were divided into eight of 6 rats/group: Diabetic normal untreated, glibenclamide (GBLI, 0.07 mL/kg) or yoyo (YB, 0.43), ruzu (RB, 0.08), fajik (FJB, 0.20), oroki (OB, 0.16), and fidson (FB, 0.43)/ mL/kg bitters respectively. Controls normal and diabetic untreated groups received intragastric carboxylmethylcellulose (CMC, 1 mL/kg) for eleven days.ResultsT2D was characterized in rats by an increased (p < 0.001–0.05) blood glucose levels (BGL), total cholesterol, triglycerides, low-density lipoprotein and alanine aminotransferase compared with control CMC group. Similarly, hepatic and pancreatic malondialdehyde (MDA) were increased by 180 and 97% respectively. Polyherbal treatments demonstrated efficacies on BGL as follow: YB (55.6%, 160.7 mg/dL); RB (59.7%, 145.2 mg/dL); FJB (59.8%, 243.4 mg/dL); OB (60.8%, 194.5 mg/dL) and FB (61.3%, 203.3 mg/dL) respectively by day 11 (versus GBLI, 65.1%) compared with control untreated diabetic rats. Also, elevated TC, LDL cholesterol, ALT were lowered (p < 0.05) by YB, FJB, and FB respectively in rats. YB, FJB, and OB lowered MDA levels in treated rats. Further, YB, RB, FJB and FB restored changes in liver, and pancreas histopathology. Predominant non-polar bioactive include oleic, hexadecanoic, octadecanoic among others following gas chromatography-mass spectrophotometry analyses.ConclusionOverall, these present results demonstrate anti-hyperglycemic potentials, although with cautions, of some polyherbal in T2D rats, which may, in part, be antioxidants mediated.

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Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Cited by 11 publications

References 96 publications

Phytochemistry and pharmacological activity of the genus artemisia

Phytochemistry and pharmacological activity of the genus artemisia

Chenopodium album extract ameliorates carbon tetrachloride induced hepatotoxicity in rat model

Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats

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