Hepatoprotective natural products

Bachar, Sitesh C.; Bachar, Ritesh; Jannat, Khoshnur; Jahan, Rownak; Rahmatullah, Mohammed

doi:10.1016/bs.armc.2020.06.003

Cited by 18 publications

(16 citation statements)

References 124 publications

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“…The leaves and stems showed a higher overall presence of photochemical groups. Phytochemicals are the bioactive compounds within plants, which produce medicinal properties (18). As such, the leaves may exhibit a larger range of health benefits than the stems and roots.…”

Section: Discussionmentioning

confidence: 99%

A phytochemical screening, antioxidant and antibacterial activity analysis in the leaves, stems and roots of Portulacaria afra

Basson

Teffo

Risenga

2022

J Herbmed Pharmacol

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Introduction: Portulacaria afra is a medicinal plant commonly used among African traditional healers to treat skin conditions and dehydration. The aim of this study was to scientifically validate the use of P. afra among traditional healers. Methods: Standard phytochemical colour tests were used to determine the presence of ten phytochemicals, using four solvents of varying polarities (hexane, ethyl acetate, methanol, and water). The antioxidant activity was determined using 1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide scavenging assays. An agar-well diffusion assay was used to determine the antibacterial activities of the leaves, stems, and roots of P. afra against Staphylococcus aureus and Escherichia coli. Results: P. afra exhibited a high phytochemical presence in the methanolic extracts, with seven out of the 10 phytochemical groups present. Flavonoids and phlobatannins were absent in all of the plant’s extracts. The methanolic root extract exhibited the highest DPPH scavenging activity (IC50=0.39) whilst the hexane leaf extract (IC50= 14.83) was the only extract to exceed the acceptable upper limit. The scavenging activity of the plant was stronger against hydrogen peroxide than it was against DPPH. The methanolic and hot water stem extracts displayed the largest zone of inhibition (of 20 mm) against E. coli. The cold-water and room-temperature water extracts, of all three plant parts, showed no zone of inhibition against either bacterial strain. Conclusion: P. afra has the capacity to be used as a nutritional supplement for its antioxidant properties, while the antibacterial properties may provide relief against E. coli infections.

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Section: Discussionmentioning

confidence: 99%

A phytochemical screening, antioxidant and antibacterial activity analysis in the leaves, stems and roots of Portulacaria afra

Basson

Teffo

Risenga

2022

J Herbmed Pharmacol

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“…Phytochemicals are compounds that occur naturally in plants as secondary metabolites. Several studies have reported the presence of different classes of secondary metabolites in the plant, including triterpenoids, flavonoids and alkaloids (Bachar et al 2020). P. capensis contains noteworthy phytochemicals; however, scientific studies investigating whether these compounds contribute to its medicinal properties are yet to be conducted.…”

Section: Phytochemistrymentioning

confidence: 99%

Pleurostylia capensis Turcz (Loes): A review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses

Thembane

2023

JOMPED

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Background: Pleurostylia capensis Turcz (Loes) is a tree species found in Africa that has been used in traditional medicine for various ailments.Aim: This review aims to investigate the phytochemistry, pharmacology and toxicity of P. capensis Turcz (Loes) and its ethnomedicinal uses.Method: A comprehensive search was conducted using electronic databases, including PubMed, Scopus and Web of Science. The keywords used were ‘Pleurostylia capensis’, ‘phytochemistry’, ‘pharmacology’, ‘toxicology’ and ‘ethnomedicine’. Studies were included if they reported on the phytochemical composition, pharmacological activities, toxicological evaluations and/or ethnomedicinal uses of Pleurostylia capensis.Results: A phytochemical analysis revealed the presence of various bioactive compounds including alkaloids, flavonoids, terpenoids and phenolic compounds. Pharmacological studies have reported the plant’s potential as an anti-inflammatory, antioxidant, antimicrobial and a potential agent for bone and articular cartilage regeneration. Toxicological evaluations have shown that the plant is safe for human consumption at recommended doses.Conclusion: The review highlights the potential of Pleurostylia capensis as a source of bioactive compounds with pharmacological activities. Toxicological evaluations have also shown that the plant is safe for human consumption. The review provides useful information for further research on the development of new drugs from natural products.Contribution: This review provides a comprehensive summary of the phytochemistry, pharmacology, toxicology of Pleurostylia capensis and its ethnomedicinal uses. The review highlights the potential of the plant as a source of bioactive compounds and provides a basis for further research on the development of new drugs from natural products.

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“…PCI has become the preferred treatment modality for STEMI patients however, for patients whose coronary anatomy renders them ineligible for such an intervention, CABG surgery is adopted as the primary reperfusion modality [ 72 ]. CABG is a surgical intervention which involves bypassing an atheromatous blockage in coronary arteries with harvested arterial or venous conduits [ 73 ]. PCI and CABG are associated with several drawbacks.…”

Section: Myocardial Infarction and Nanomedicinementioning

confidence: 99%

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Karam

Fahs

Maatouk

et al. 2022

Materials Today Bio

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Hepatoprotective natural products

Cited by 18 publications

References 124 publications

A phytochemical screening, antioxidant and antibacterial activity analysis in the leaves, stems and roots of Portulacaria afra

A phytochemical screening, antioxidant and antibacterial activity analysis in the leaves, stems and roots of Portulacaria afra

Pleurostylia capensis Turcz (Loes): A review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

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