Hepatoprotective Potential of Elsholtzia densa Against Acute and Chronic Models of Liver Damage in Wistar Rats

Abstract

The aim of the present study was to evaluate the hepatoprotective activity of methanolic extract of Elsholtzia densa against experimentally induced acute (CCl) and chronic (paracetamol) liver injury in albino wistar rats. Activity was measured by monitoring the serum levels of ALT, ALP AST and LDH, total protein levels, bilirubin and albumin. The results of the CCl and paracetamol-induced liver toxicity experiments showed that the rats treated with the methanolic extract of Elsholtzia densa exhibited a significant decrease in biochemical parameters as well as the proteins, which were all elevated in the CCl and paracetamol group. The extract at a concentration of 300 mg/kg body wt. showed a significant decline (P≤0.05) in the levels of AST, ALT, ALP and LDH to 69.50±2.23IU/L, 60.01±2.25IU/L,46.20±2.24 IU/L and 150.21±5.68IU/L in CCl injected animals and 51.12±2.20 IU/L,49.15±3.25 IU/L, 44.12±2.56 IU/L and 125.15±4.45 IU/L in paracetamol-treated animals when compared to the control group. The activities of tissue antioxidants GSH, GPx, GR, GST and CAT was significantly (P≤0.05) restored in dose dependent manner in animals treated with extracts as with acute and chronic hepatotoxic models. The current study confirmed the hepatoprotective effect of methanolic extract of Elsholtzia densa against the model hepatotoxicant CCl and paracetamol.

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

“…The improvement of survival rates and attenuation of liver histological damage in APAP-induced liver injury model further validated that SAFE could alleviate liver injury. These results were confirmed by other previous findings, the increase of survival rate, decrease of serum markers, and alleviation of liver histological damage in APAP-induced liver damage after the treatment of different plant extracts [62, 63]. Normally, clinical dose of APAP mainly binds to glucuronic acid or sulfate in the liver and then is excreted into plasma or bile [64, 65].…”

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

“…Pourahmad J et, al. revealed that the hepatotoxicity caused by diclofenac is associated with oxidative stress [13]. On the other hand, liver toxicity decreases with antioxidant compounds, which is another indication of the effect of oxidative stress and free radicals on liver toxicity [14][15][16].…”

Panorama atual do modelo de indução da hepatotoxicidade por paracetamol para estudos de hepatoproteção em ratos: Scoping review / Current overview of the model of induction of hepatotoxicity by paracetamol for studies of hepatoprotection in rats: Scoping review

“…A dose mais utilizada pelos autores foi a de 2.000 mg/kg, representando 26 trabalhos no total de 114, seguido de 1.000 g/kg (21 trabalhos), o gráfico abaixo permite visualizar melhor a distribuição das doses encontradas (Figura 5). A metodologia de indução também foi muito diversificada, desde doses únicas (ELBE et al, 2018) até indução contínua por dias (ZARGAR et al, 2018).…”