Hepatoprotective Potential ofSargassum muticumagainst STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway

Abstract

Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Exposure to the MESM tremendously modulated the levels of hepatic enzyme markers ALP, ACP, ALT, and AST in Groups 3 and 4. The cytokine network was well regulated by suppressing the release of cytokines, and the levels of caspase-3 and caspase-9 were also reduced in Groups 3 and 4. The present study suggests that MESM treatment at 200 and 500 mg protected the liver and also minimizes the glucose level. Thus, the MESM plays a key role in rejuvenating the liver and can modulate diabetes’s pathogenic effect by reducing the glucose level.

Shorea roxburghii Leaf Extract Ameliorates Hyperglycemia Induced Abnormalities in High Fat/Fructose and Streptozotocin Induced Diabetic Rats

“…The secretion of abnormal levels of liver function enzymes in the blood are vital indicators of liver injury in DM. ALT, AST and ALP levels have been shown to be increased in hepatic insulin resistance and T2DM . In this study, SRL significantly reduced the level of these biomarkers of liver injury in the treated diabetic rats.…”

“…ALT, AST and ALP levels have been shown to be increased in hepatic insulin resistance and T2DM. [28,29] In this study, SRL significantly reduced the level of these biomarkers of liver injury in the treated diabetic rats.…”

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

“…Some studies have shown that curcumin protects astrocytes from oxidative stress, thus potentially using them for treating various neurodegenerative diseases [51]. In addition, DM is highly correlated with liver inflammation, cirrhosis, apoptosis, and ultimately causes liver malfunction [52].…”

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed High-fat Diet or a High-fat Diet Combined with STZ Treatment

“…Some studies have shown that curcumin protects astrocytes from oxidative stress, thus potentially using them for treating various neurodegenerative diseases [39]. In addition, DM is highly correlated with liver inflammation, cirrhosis, apoptosis, and ultimately causes liver malfunction [40]. The results of our experiment showed that a high-fat diet combined with streptozotocin treatment significantly upregulated MDA levels and significantly downregulated SOD levels in experimental rats.…”