Hepatoprotective Potentials of Ethanolic Extract of Solanum melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats' and Liver Section Histology

Mbah, Uchendu O.; Egbuonu, Anthony Cemaluk C.; Achi, Ngozi; Nwanne, Ijere D.; Jeremiah, Obinna

doi:10.9734/ibrr/2019/45935

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Recall the groups 3, 4, 5 and 6 showed no significant difference (P =0.05) compared to the control group. This revealed that the extract may have ameliorated the MSG-induced toxic responses in the rats at those different dosages [3,7,12,13].…”

Section: Histology Results (H and E X400)mentioning

confidence: 88%

“…as an antioxidant, owing to its phytochemical contents [3,7,8] antidiabetic [9,10] hypolipidaemic agent [11,12] cardioprotective with haema-improvement roles [12] and a hepatoprotective agent [13].…”

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confidence: 99%

“…One could be consuming these foods in high quantities without consideration to the effects of MSG inadvertent use. There has been a report of possible liver dysfunction upon consumption of MSG in high concentration [13,15,16] enhanced appetite and food intake that could lead to obesity and even excitotoxicity in cells via its catabolic product; glutamate [17,18]. Others reported the adverse influence of MSG in animals to include impaired lipid metabolism and cardiac function [12,17] which could induce oxidative stress [3,19] and alter renal function [15,17].…”

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confidence: 99%

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Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

Mbah

Nwanne²,

Jeremiah

et al. 2019

Journal of Diagnostics

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This study evaluated the renal biofunction potentials of ethanolic extract of Solanum melongena Linn fruit on monosodium glutamate-intoxicated rats' and kidney histology using standard protocol. Twenty four Wistar rats that weighed 105.00 ± 7.00 g were used. The rats were assigned into 6 groups of 4 each and fed thus: Group 1 (control, feed and distilled water only), Group 2 (8000mg/kg body weight monosodium glutamate (MSG)), Group 3 (300mg/kg body weight (bw) the sample extract), Group 4 (8000mg/kg bw MSG + 100mg/kg bw the sample extract), Group 5(8000mg/kg bw MSG+ 300mg/kg bw the sample extract) and Group 6 (8000mg/kg bw MSG+ 500mg/kg bw the sample extract) daily for 14 days. The results were expressed as mean ± S.E.M and one-way analysis of variance (ANOVA), followed by a Duncan posthoc test was done to test for significance using SPSS version 22.0. The exposure of MSG resulted in a significant (P =0.05) increase in the activities of serum urea, creatinine, potassium ion, chloride ion, and sodium ion compared to the control. MSG and ethanolic extract of Solanum melongena Linn fruit co-treated groups at different concentrations were significantly (P =0.05) reduced to become comparable to the control group. MSG consumption in high concentration alters renal biofunction and this is also evident in the histology of the studied rats' kidney sections. However, the protective roles of ethanolic extract of Solanum melongena Linn fruit were notably at 500mg/kg of body weight in rats, a pointer to the dose-dependent function. Contribution/Originality: This research underscores the possible MSG-intoxication effects on the renal system in high concentration be it inadvertently or not and as well as the possible ameliorative roles of Solanum melongena Linn fruit on the affected organ on a dose-dependent function. 1. INTRODUCTION Solanum species (eggplants) belong to the family of Solanaceae and the plant genus Solanum. Solanum melongena is an economically important vegetable crop that is widely cultivated in the tropical region and a good source of vitamins, minerals, free water and phytochemicals [1-3]. This family includes fruits and vegetables such as potato (Solanum tuberosum L.), tomato, peppers and other medicinal plants like Atropa belladonna L. (deadly

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Section: Histology Results (H and E X400)mentioning

confidence: 88%

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confidence: 99%

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confidence: 99%

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Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

Mbah

Nwanne²,

Jeremiah

et al. 2019

Journal of Diagnostics

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Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well‐being. Infections due to virus, immune problems, cancer, alcohol abuse, and an overdose of drugs are some of the causes of liver diseases. Antioxidants derived from medicinal plants and conventional dietary sources can protect the liver from damages caused by oxidative stress system and various chemicals. Plants and plant‐derived phytochemicals are appealing hepatoprotective agents since they have less side effects and still there is a lot of interest shown in using herbal tonics for treating liver disorders. This review therefore primarily focuses on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective. Hosta plantaginea, Ligusticum chuanxiong, Daniella oliveri, Garcinia mangostana, Solanum melongena, Vaccinium myrtillus, Picrorhiza kurroa, and Citrus medica are some potential plants having hepatoprotective effects. We conclude that these phytochemicals and the plant extracts listed above are used in the future to treat a variety of liver diseases, additional research is still needed to develop safer and more potent phytochemical drugs.

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Phytochemical constituents and mineral composition of fruits of Solanum melongena and Cucumis sativus

Imo¹,

Abu²,

Emmanuel³

et al. 2020

Int. J. Curr. Res. Biosci. Plant Biol.

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Hepatoprotective Potentials of Ethanolic Extract of Solanum melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats' and Liver Section Histology

Cited by 4 publications

References 15 publications

Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Phytochemical constituents and mineral composition of fruits of Solanum melongena and Cucumis sativus

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