Hepatoprotective studies of a fraction from the fruits of Terminalia belerica roxb. On experimental liver injury in rodents

Abstract

The effects of an orally administered fraction (TB5) from the fruits of Tenninalia belerica in experimental liver injury induced by carbon tetrachloride (CC4) were studied. Hexobarbitone-induced sleep, zoxazolamineinduced paralysis, transaminases, bilirubin, total protein in serum and microsomal lipid peroxidation and triglycerides in liver were used as indices of liver injury.A significant hepatoprotective effect was observed as evident from shortened hexobarbitone 'sleep time' and zoxazolamine 'paralysis time' when compared with CCI, alone. Pre-and post-treatment of TB5 reduced, in a dose dependent manner, the elevated levels of serum tranaminases and bilirubin in rats, thus demonstrating its effect both as a prophylactic and curative. Its protective effects on microsomal lipid peroxidation and triglycerides in liver suggest a restorative effect in the process of CCC-induced liver damage. TB5 did not show any signs of toxicity up to oral doses of 3.2 g/kg in mice.

Hepatoprotective effect of Barrisal (herbal drug) on carbon tetrachloride induced hepatic damage in rats

“…CCl 4 treatment also causes significant increase in bilirubin level (Hyperbilirubinemia), because CCI 4 is also one of the most useful model to the severity of necrosis (Zimmerman, 1973). While there was no change in total protein level, these findings were in accordance with the observation that protein in general and albumin level in particular remains unchanged in acute liver damage (Anand et al, 1994). This brief period might not be sufficient to demonstrate any rise in serum protein levels.…”

Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia bellerica fruit

“…Dwivedi et al (1994), Srivastava et al (1992) and Khan and Gilani (in press) reported that Terminalia bellerica lowers the arterial blood pressure. A water soluble fraction obtained from the defatted fruits of Terminalia bellerica caused protection against CCl 4 -induced liver injury in rodents (Anand et al, 1994). In a clinical study, Terminalia bellerica was found to possess antispasmodic, antiasthmatic and antitussive effects (Trivedi et al, 1979).…”

Emodin reverses CCl4 induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence

“…The phenolic moiety of emodin might interact with membrane components to break the peroxidative chain reaction to stabilize the membrane. Various plant extracts and their active principles, that is Terminalia belerica 43 and gallic acid 40 have also been reported to possess membrane stabilizing effects against oxidative insult. The BSP is metabolized by MDMEs in liver and increase in BSP retention in plasma clearly indicates the fall in excretory capacity of liver 44 or unavailability of MDMEs in toxic conditions 45 .…”