Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Pallerla, Praneetha; Yellu, Narsimha Reddy

doi:10.1186/s40816-019-0123-1

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…In this study, the activity level of antioxidant enzymes of liver tissue was decreased which was indicator of oxidative stress generated after administration of CCl4 in mice. Decrease in the level of Glutathione peroxidase, catalase and superoxide dismutase is also indicator of lipid peroxidation (Pallerla et al, 2019). These enzymes scavenged the free radicals in coordination with each other.…”

Section: Hepatoprotective Studymentioning

confidence: 99%

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

2021

THE JAPS

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Ficus carica (Fig) is considered to be first plant which is cultivated on earth. Fruit of this plant is delicious, medicinally important and is being consumed by human population since centuries. The present study was designed to assess the role of Ficus carica fruit as hepatoprotective agent in animal model. Crude methanolic extract of Ficus carica fruit and its derived n-hexane and aqueous fractions were used to study its curative effect on CCl4 induced toxicity in mice. Animals were divided into seven groups (n=5). Group I animals were treated with normal saline only, Group II was treated with olive oil (vehicle control), Group III was treated with CCl4 (toxic control) 0.2 ml/kg b.w, Group IV was treated with silymarin (standard drug) and Group V, VI and VII were treated with plant extract and fractions at different doses (200 mg/kg and 400 mg/kg b.w). Hepatoprotective effect was determined by investigating liver markers (Alanine transaminase, Aspartate aminotransferase, Alkaline phosphatase and bilirubin) using blood while in vivo antioxidant potential was found out by determining the activity of Glutathione peroxidase, Catalase and Superoxide dismutase. Histopathology of liver was also done. The aqueous fraction showed significant hepatoprotective effect against toxicity in mice as well as exhibited higher antioxidant value. The aqueous fraction of Ficus carica would be a good candidate for pharmaceutical industry as a hepatoprotective agent.

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Section: Hepatoprotective Studymentioning

confidence: 99%

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

2021

THE JAPS

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Hepatoprotective effects of extracts, fractions and compounds from the stem bark of Pentaclethra macrophylla Benth: Evidence from in vitro and in vivo studies

Bomgning

Ponou

Fotio

et al. 2021

Biomedicine & Pharmacotherapy

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Hepatoprotective Potential of Pomegranate in Curbing the Incidence of Acute Liver Injury by Alleviating Oxidative Stress and Inflammatory Response

et al. 2021

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Hepatitis is an inflammatory disease of the liver and is considered one of the leading causes of death worldwide. Due to its scavenging activity, Punica granatum may be used for the treatment and prevention of liver diseases. The current study investigated the protective mechanism underlying the effects of pomegranate against a rat model of carbon tetrachloride–induced liver injury. Intraperitoneal injection of CCl4 resulted in liver inflammation, oxidative stress, and accumulation of lipid in hepatocytes. CCl4 induced a downregulation of superoxide dismutase (SOD), glutathione (GSH), and melonaldehyde (MDA). Pomegranate protection was assessed in terms of biochemical parameters, histopathology, and immunohistochemistry. Promegranate administration decreased inflammation, elevated serum enzymes and ROS production, and countered the debilitating effects caused by CCl4. In addition, CCl4-induced histological changes were absent in the crude pomegranate extract group, which also enhanced the scavenging activity of reactive oxygen species by enhancing the antioxidant defense mechanism as confirmed by detecting MDA, SOD, and GSH expressions. The migration of CD68+ macrophages was halted at the injured area of the central vein and the number of macrophages was reduced to the normal control by the crude extract compared to the positive control silymarin group. Likewise, protective effects of ethylacetate and the aqueous fraction of the crude extract were also observed. However, the butanol and n-hexane fractions displayed increased levels of ALT, AST, and ALP as compared to silymarin. About 25% damage to hepatocytes was observed in the butanol and n-hexane group by histopathological examination, which is a little better compared to the CCl4-treated group. The crude extract and its ethyl acetate and aqueous fractions may be accountable for the hepatoprotective potential of Punica granatum, which was further confirmed by in vivo experiments. Together, these findings confirm that pomegranate exerts hepatoprotective activity against CCl4-induced oxidative stress and liver damage.

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Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Cited by 3 publications

References 14 publications

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

Hepatoprotective effects of extracts, fractions and compounds from the stem bark of Pentaclethra macrophylla Benth: Evidence from in vitro and in vivo studies

Hepatoprotective Potential of Pomegranate in Curbing the Incidence of Acute Liver Injury by Alleviating Oxidative Stress and Inflammatory Response

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