Hepatosis Dietetica, Nutritional Myopathy, Mulberry Heart Disease and Associated Hepatic Selenium Levels in Pigs

Moir, D C; Masters, H. G.

doi:10.1111/j.1751-0813.1979.tb15855.x

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…In one experimental study, tissue selenium concentration did not appear to be related to the incidence of MHD‐related lesions (Sharp et al., 1972b). In Western Australia, hepatic selenium concentrations were not low in pigs with MHD (Moir and Masters, 1979). In field cases, heart and kidney selenium concentrations were similar in pigs of either group, i.e.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E and Selenium Levels are Within Normal Range in Pigs Diagnosed with Mulberry Heart Disease and Evidence for Viral Involvement in the Syndrome is Lacking

Shen

Thomas

Ensley

et al. 2011

Transboundary and Emerging Diseases

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Mulberry heart disease (MHD) in pigs is characterized by lesions of acute haemorrhagic myocarditis and myocardial necrosis. The objectives of this study were to determine the levels of vitamin E and selenium and 13 other trace minerals in heart and liver tissues and to determine the prevalence of certain viral infections in heart tissues from MHD-affected and MHD-unaffected pigs and the vitamin E and selenium concentration in feed samples from selected farms with MHD. Based on the pathological examination, 114 pigs were separated into MHD lesion-negative (L-NEG) (n = 57) and MHD lesion-positive (L-POS) (n = 57) groups. Seventy-three samples (40 L-NEG and 33 L-POS) were subjected to chemical analysis, and 66 (32 L-NEG and 34 L-POS) were subjected to PCR detection for viral pathogens. Lower (P < 0.05) levels of myocardial copper, lower (P < 0.05) levels of hepatic magnesium and higher (P < 0.05) levels of myocardial and hepatic sodium were detected in the L-POS cases. Although lower (P < 0.05) levels of hepatic selenium were detected in L-POS group, all were within the normal range. Analysis of feed samples (n = 22) revealed that selenium levels in all the samples were above the legal limit (0.3 ppm) for pigs. Vitamin E levels in all feed samples were above 20 IU/kg. Among the 66 pigs subjected to PCR detection, there were 19, 4, 13, 8, 2 and 1 animals positive for porcine circovirus type 2, porcine reproductive and respiratory syndrome virus, pan-herpes virus, porcine enterovirus, pan-pestivirus and porcine parvovirus, respectively. Clear evidence of viral association with L-POS was lacking.

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Section: Discussionmentioning

confidence: 99%

Vitamin E and Selenium Levels are Within Normal Range in Pigs Diagnosed with Mulberry Heart Disease and Evidence for Viral Involvement in the Syndrome is Lacking

Shen

Thomas

Ensley

et al. 2011

Transboundary and Emerging Diseases

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“…Deficiencies of vitamin E result in a wide variety of pathological changes in animal tissues. The main manifestations in pigs of vitamin E deficiency and Se deficiency are dietetic microangiopathy or Mulberry heart disease, hepatosis dietetica, and nutritional myopathy (Moir & Masters, 1979). Death from vitamin E and Se deficiencies, which is most likely to be seen in weaned pigs, is sporadic but can reach 5-10% of the herd (Van Vleet & Kennedy, 1989).…”

Section: Lipid Peroxidation: Vitamin E Requirementmentioning

confidence: 99%

“…Death from vitamin E and Se deficiencies, which is most likely to be seen in weaned pigs, is sporadic but can reach 5-10% of the herd (Van Vleet & Kennedy, 1989). It is suggested that mulberry heart disease is particularly related to vitamin E deficiency (Moir & Masters, 1979;Rice & Kennedy, 1989).…”

Section: Lipid Peroxidation: Vitamin E Requirementmentioning

confidence: 99%

Lipid peroxidation status as an index to evaluate the influence of dietary fats on vitamin E requirements of young pigs

Wang

Leibholz²,

Bryden

et al. 1996

Br J Nutr

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The aims of the present study were to establish a suitable criterion for estimating the vitamin E requirement for young pigs, and to investigate the influence of dietary fats on the requirement of this nutrient. In Expt 1 weaned pigs were given a semi-purified diet supplemented with 0,20, or 100 mg DLa-tocopheryl acetate/kg. Pigs in Expt 2 were fed on diets containing 10 g sunflower oil (SO) stripped of vitamin E/kg in diets 1 and 2,100 g SO/kg in diets 3 and 4, and 100 g tallowkg in diet 5. Diets 2,4 and 5 were supplemented with DL-a-tocopheryl acetate at 20 mg/kg for 0-28 d and 50 mg/kg for 29-56 d of the experiment respectively. Results showed that vitamin E concentrations in plasma and tissues reflected dietary levels of vitamin E. No apparent clinical signs of vitamin'E deficiency were observed, but pigs fed on diets without vitamin E supplementation showed a higher (P < 0.05) lipid peroxidation status as indicated by Sobarbituric acid-reactive substances in erythrocytes, and ethane and pentane levels in exhaled gases than those fed on supplemental diets. This indicated that the former was deficient in vitamin E. Data in Expt 1 suggested that supplementation with 20 mg DL-a-tocopheryl acetate/kg is adequate for young pigs when the diet contains 30 g lard/kg. However, results in Expt 2 showed that this level was inadequate when the diet contains 100 g SO/kg or its equivalent to 70 mg polyunsaturated fatty acids (PUFA)/g. Vitamin E and lipid peroxidation status of pigs were affected by both dietary vitamin E and dietary PUFA. This demonstrates that the requirement for vitamin E in young pigs increases as PUFA levels in the diet increase. The present study shows that lipid peroxidation response of pigs is a suitable index to evaluate vitamin E requirements.

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“…Vitamin E addition confirmed the particular function of the vitamin as a lipid antioxidant and should be taken into consideration when diets with high PUFA concentrations are fed. (Fink et al, 1967;Moir and Masters, 1979), nutritional muscular dystrophy (NMD) also referred to as white muscle disease is one main consequence of dietary Se deficiency which is typical for ruminants (Hoshino et al, 1989;Bostedt and Schramel, 1990;Kozat, 2007) and turkeys (Scott et al, 1967). According to the literature, Se is the most effective nutritive factor for preventing NMD of gizzard, heart and skeletal muscle in turkeys (Scott, 1966;Scott et al, 1967;.…”

Section: Discussionmentioning

confidence: 99%

Investigation into selenium requirement of growing turkeys offered a diet supplemented with two levels of vitamin E

Mueller

Fischer

Most

et al. 2009

Animal Physiology Nutrition

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To evaluate dietary selenium (Se) requirement in turkeys offered a diet supplemented with two levels of vitamin E (VE), 96 newly hatched male BIG 6 chicks (58.4 +/- 4.12 g) were divided into eight groups of 12 animals each and fed maize soya diets containing 0.05, 0.10, 0.20 and 0.30 mg Se/kg from sodium selenate in combination either with the natural VE content (approximately 10 IU/kg) or with a VE addition of 50 IU/kg. Animals from all the groups were highly performant and their final body weights (1746 +/- 190 g) after 35 days on experiment were not significantly different. According to its dietary supply, Se concentration in the liver and plasma increased dose dependently. Independent of dietary VE, the activities of GPx3 in plasma and of GPx1 in liver and breast muscle increased to a larger extent in turkeys supplemented with 0.10 and 0.20 mg Se/kg in relation to animals with low marginal Se supply (0.05 mg/kg). Supplementation of 0.30 mg Se/kg only slightly increased further selenoprotein activities. 2-Thiobarbituric acid reactive substances in the liver were strongly reduced by dietary VE, but not by Se. Plasma aspartate aminotransferase (AST) and creatine kinase (CK) activities did not show muscular lesions in none of the groups. Although there were no signs of muscular lesions even in turkeys with marginal Se and moderate VE supply, the activity of selenoproteins in various organs increased up to 0.30 mg Se/kg diet, independent of VE supply. It was concluded that for growing turkeys the Se supply should meet at least a level of 0.20 mg/kg diet as currently recommended by the National Research Council and Gesellschaft für Ernährungsphysiologie. Vitamin E addition confirmed the particular function of the vitamin as a lipid antioxidant and should be taken into consideration when diets with high PUFA concentrations are fed.

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Hepatosis Dietetica, Nutritional Myopathy, Mulberry Heart Disease and Associated Hepatic Selenium Levels in Pigs

Cited by 10 publications

References 10 publications

Vitamin E and Selenium Levels are Within Normal Range in Pigs Diagnosed with Mulberry Heart Disease and Evidence for Viral Involvement in the Syndrome is Lacking

Vitamin E and Selenium Levels are Within Normal Range in Pigs Diagnosed with Mulberry Heart Disease and Evidence for Viral Involvement in the Syndrome is Lacking

Lipid peroxidation status as an index to evaluate the influence of dietary fats on vitamin E requirements of young pigs

Investigation into selenium requirement of growing turkeys offered a diet supplemented with two levels of vitamin E

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