Hepatosplenic candidiasis after neutropenic phase of acute leukaemia

Abstract

Hepatosplenic candidiasis following granulocytopenic periods is a relatively recently recognised problem in immunocompromised patients, particularly in those with acute leukaemia. We present three patients in whom diagnosis of hepatosplenic candidiasis was suspected on the basis of ultrasonographic (US), computed tomographic (CT) findings and confirmed by laparoscopy and biopsy of liver lesions. All three patients were successfully treated briefly with amphotericin B, followed by a longer period of fluconazole. In one patient laparotomy and surgical evacuation of abscesses was performed. This condition could be more often recognised by careful follow-up of liver function test, C-reactive protein level, ultrasonography, CT and MRI after recovery from chemotherapy-induced neutropenia.

Ojo de buey en tomografía hepática.

“…crónica diseminada, se inició el tratamiento con fluconazol durante tres meses, con el cual la paciente mejoró clínicamente (18)(19)(20). La imagen tomográfica de control un mes después mostró una resolución casi completa de las lesiones iniciales (figura 4), hallazgo con el que se continuó la quimioterapia programada.…”