Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Lambertucci, José Roberto; Cota, Gláucia; Pinto-Silva, Rogério Augusto; Serufo, José Carlos; Gerspacher-Lara, Rogério; Drummond, Sandra; Antunes, Carlos Maurício de Figueiredo; Nobre, Vandack; Rayes, Abdunnabi Ahmed Mustafa

doi:10.1590/s0074-02762001000900022

Cited by 49 publications

(65 citation statements)

References 13 publications

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“…However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation 10,14,15 .…”

Section: Clinical Definition Of Hepatosplenicmentioning

confidence: 99%

“…In endemic areas, at least four groups of individuals have been identifi ed using the data obtained by abdominal palpation and US examination: 1) a spleen >13cm and liver periportal fi brosis, as confi rmed by US; 2) a palpable spleen and spleen >13cm, as measured by US; 3) a spleen >13cm using US and 4) a palpable spleen 15,30 .…”

Section: Ultrasound In Hepatosplenic Schistosomiasismentioning

confidence: 99%

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Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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“…However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation 10,14,15 .…”

Section: Clinical Definition Of Hepatosplenicmentioning

confidence: 99%

Section: Ultrasound In Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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“…In Figure 1, [21][22][23][24] . All patients had three negative parasitological stool examinations by the Kato-Katz technique and they also reported previous treatment for schistosomiasis ranging from 2 to 5 years before being enrolled in the present investigation.…”

Section: Patientsmentioning

confidence: 99%

“…Since then, over 13 million treatments/ re-treatments were undertaken in the country 4,[18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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“…They are surrounded by granulomatous inflammatory reactions that eventually lead up to portal branch obstruction. The consequence is chronic deposition of collagen in periportal spaces, seen as fibrous plaques, while liver architecture is considerably preserved (Bogliolo 1957, Lambertucci 1993, Andrade et al 1997, Lambertucci et al 2001, Andrade 2004, Gryseels et al 2006. The correspondent clinical manifestation, hepatosplenic schistosomiasis, includes portal hypertension and its complications -splenomegaly, collateral circulation, oesophageal varices and ultimately, death from variceal bleeding.…”

mentioning

confidence: 99%

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Marinho¹,

Bretas

Voieta³

et al. 2010

Mem. Inst. Oswaldo Cruz

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Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Cited by 49 publications

References 13 publications

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

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