Hepatosplenic T-cell lymphoma: a rare cause of hepatosplenomegaly

Lladò, Ana; Tomé, Ana; Henrique, Maria; Farinha, Pedro

doi:10.1136/bcr-2013-009423

Cited by 4 publications

(4 citation statements)

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“…If none of the above-mentioned tests are positive, possibility of other infective agents should not be forgotten—CMV [ 37 ], malaria [ 38 ], parvovirus b19 [ 39 ], influenza [ 40 ], rubella [ 41 ], hepatitis A [ 42 ], adenovirus [ 43 ], schistosomiasis [ 44 ], histoplasmosis [ 45 ], MAV [ 34 ], typhoid fever [ 47 ]—and the samples should be tested against these microorganisms.…”

Section: Discussionmentioning

confidence: 99%

“…Next step for differential diagnosis, if none of the infective agents are confirmed, should be exclusion of malignancies, which require a more invasive approach—biopsy of bone marrow, spleen, and lymph nodes [ 34 , 47 – 50 ]. We recommend obtaining enough specimens to test them for splenic tumors, sarcoidosis, Gaucher’s disease as well [ 51 – 53 ].…”

Section: Discussionmentioning

confidence: 99%

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Visceral leishmaniasis misdiagnosed as an upper respiratory infection and iron-deficiency anemia in a 20-month-old male patient: a case report

Chakhunashvili,

Kvirkvelia

2024

J Med Case Reports

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Background Visceral Leishmaniasis should be suspected in every patient with a history of splenomegaly, fever, and pancytopenia. It is one of the most dangerous forms of infection and prompt recognition is the key to positive outcome. Case presentation A 20-month-old Caucasian male patient was brought to our hospital as an outpatient with the complaint of persistent fever, which did not improve with empiric antibiotic treatment (> 96 hour after the initial dose). The antibiotic treatment had been prescribed by primary care physician at polyclinic, who also referred the patient to hematologist due to anemia, who prescribed iron supplement. Despite multiple subspecialist visits, bicytopenia was, unfortunately, left unidentified. Upon physical examination no specific signs were detected, however, spleen seemed slightly enlarged. Patient was admitted to the hospital for further work-up, management and evaluation. Abdominal ultrasound, complete blood count and c-reactive protein had been ordered. Hematologist and infectionist were involved, both advised to run serology for Epstein-Barr Virus and Visceral Leishmaniasis. The latter was positive; therefore, patient was transferred to the specialized clinic for specific management. Conclusion Both in endemic and non-endemic areas the awareness about VL should be increased among the medical professionals. We also recommend that our colleagues take the same approach when dealing with bicytopenia and fever, just as with pancytopenia and fever. The medical community should make sure that none of the cases of fever and pancytopenia are overlooked, especially if we have hepatomegaly and/or splenomegaly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Visceral leishmaniasis misdiagnosed as an upper respiratory infection and iron-deficiency anemia in a 20-month-old male patient: a case report

Chakhunashvili,

Kvirkvelia

2024

J Med Case Reports

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“…HSTCL has a dismal clinical course with poor prognosis, and a reported median overall survival of 6–11 months 14 31 32. To date, the most common therapeutic strategies have been CHOP and HyperCVAD (fractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone), alternating with high-dose methotrexate and cytorabine, followed by autologous or allogeneic stem cell transplantation 3 7 14.…”

Section: Discussionmentioning

confidence: 99%

Hepatosplenic T-cell lymphoma in a young immunocompetent man

et al. 2016

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Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive type of peripheral T-cell lymphoma that is characterised by extranodal disease, with infiltration and proliferation of malignant T-cells within the liver, spleen and bone marrow. The authors report the case of a young immunocompetent man, who was admitted to the hospital with a history of prolonged, unexplained fever, fatigue and weight loss. Initial blood work showed mild pancytopaenia and imaging studies revealed hepatosplenomegaly. The diagnosis was challenging, initially mimicking infectious disease, and it required an extensive investigation that ultimately revealed the characteristic clinical, histopathological and cytogenetic features of HSTCL. The clinical course was aggressive, and despite multiagent chemotherapy, the patient died 4 months after the diagnosis. This case highlights the difficulty of diagnosing HSTCL and the importance of considering it in a differential diagnosis of hepatosplenomegaly in young men who present with constitutional symptoms and no lymphadenopathy.

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“…A imunofenotipagem das células podem auxiliar no raciocínio pois tumores usualmente expressam CD2, CD3 superfi cial, CD7 e CD16 e em muitos casos tumores não expressam CD4, CD5 ,e CD8. A maioria dos casos de linfoma hepatoesplênico de células T expressa receptores de Células T γδ (LLADÓ et al, 2014).…”

Section: A Etiologia Da Hepatoesplenomegaliaunclassified

Doenças infecciosas: inovações e aprendizados para área médica

2023

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CERONI, Dimitri et al. Osteoarticular infections in young children: what has changed over the last years?. Swiss medical weekly, v. 144, p. w13971, 2014. KROGSTAD P.et al. Osteomielite. In: Feigin e Cherry's Textbook of Pediatric Infectious Diseases, 8ª ed. Elsevier, Filadélfia. p.516, 2018. KROGSTAD, P.; PHILLIPS, William A. Hematogenous osteomyelitis in children: management. UpToDate Online.[web-based textbook]. Baron EL (ed), UpToDate, Waltham, MA, 2019. KRZYSZTOFIAK, Andrzej et al. Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children. Italian journal of pediatrics, v. 47, n. 1, p. 1-12, 2021. LE SAUX, Nicole. Diagnosis and management of acute osteoarticular infections in children. Paediatrics & Child Health, v. 23, n. 5, p. 336-343, 2018. MCNEIL, J. Chase et al. Clinical and microbiologic variables predictive of orthopedic complications following Staphylococcus aureus acute hematogenous osteoarticular infections in children. Clinical Infectious Diseases, v. 69, n. 11, p. 1955-1961, 2019. MCNEIL, J. Chase. Acute hematogenous osteomyelitis in children: clinical presentation and management. Infection and drug resistance, v. 13, p. 4459, 2020. DE MESY BENTLEY, Karen L. et al. Evidence of Staphylococcus aureus deformation, proliferation, and migration in canaliculi of live corti-tanto, por mais que seja uma doença amplamente conhecida, sempre será uma síndrome que exige cuidado e atenção em sua abordagem, haja vista o impacto que teve na história da medicina ao longo dos anos e que permanece tendo. Deve ser dada sempre a devida atenção à prevenção da doença, bem como seus aspectos clínicos e sociais, buscando cada vez mais formas de tratamento.Além disso, torna-se inegável a participação do Sistema Único de Saúde em diagnosticar, prevenir, informar, notificar e servir de apoio para o contexto da Aids, comprovando que o Brasil, de maneira geral, tem tomado diversas medidas que tem tornado eficaz sua diminuição, que é evidenciada estatisticamente e pela queda de 18,7% dos casos nos últimos anos.

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Hepatosplenic T-cell lymphoma: a rare cause of hepatosplenomegaly

Cited by 4 publications

References 16 publications

Visceral leishmaniasis misdiagnosed as an upper respiratory infection and iron-deficiency anemia in a 20-month-old male patient: a case report

Visceral leishmaniasis misdiagnosed as an upper respiratory infection and iron-deficiency anemia in a 20-month-old male patient: a case report

Hepatosplenic T-cell lymphoma in a young immunocompetent man

Doenças infecciosas: inovações e aprendizados para área médica

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