Hepatotoxic and haematological effects of Nigerian Bonny light crude oil in male albino rats

Orisakwe, Orish Ebere; Akumka, David D.; Njan, Anoka A.; Afonne, Onyenmechi Johnson; Okechi, O. O.

doi:10.1080/02772240400026823

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…Studies that demonstrate detrimental effects of BLCO in different organs and animals exist. Oral administration of BLCO has been shown to be hematotoxic with severe pathologic liver changes in the forms of necrosis and oedema . It has also been reported to be nephrotoxic .…”

Section: Introductionmentioning

confidence: 98%

“…Oral administration of BLCO has been shown to be hematotoxic with severe pathologic liver changes in the forms of necrosis and oedema. 2 It has also been reported to be nephrotoxic. 3,4 Intraperitoneal injection of adult guinea pigs with BLCO at 2.50 and 5.0 ml kg À1 body weight for 2 days increased the availability of crude oil hydrocarbons in the liver cells with subsequent induction of unscheduled mitochondrial DNA synthesis and alteration of mitochondrial/endoplasmic reticulum Ca 2+ sequestration or Ca 2+ -concentration gradient, leading to inhibition of Ca 2+ influx into the cytosol as well as increased regenerative DNA concentration in partially hepatectomized rat liver.…”

Section: Introductionmentioning

confidence: 99%

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Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil

Adedara

Farombi

2012

Cell Biochemistry & Function

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The use of Nigerian bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders, burns, foot ulcers and reproductive capacity is a common practice in the southern part of Nigeria. Towards understanding the mechanism and the reversibility of hepatotoxicity induced by BLCO, adult male Wistar rats were orally administered with BLCO at 0, 50, 100 and 200 mg kg(-1) for 21 days. One-half of the rats were sacrificed on day 22, whereas the remaining half stayed for an additional 21 days without treatment. Whereas the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione S-transferase were significantly (p < 0.05) increased, gamma glutamyl transferase activity was significantly decreased in a dose-dependent manner. The levels of glutathione, hydrogen peroxide and malondialdehyde were significantly elevated in BLCO-treated animals. In addition, hepatic degeneration was accompanied with elevation in serum aminotransferases activities without affecting bilirubin levels. Whereas most of the above-mentioned parameters were consistent in animals from withdrawal experiment, both total and conjugated bilirubin levels were significantly increased after 21 days of BLCO-treatment withdrawal. Taken together, BLCO-induced hepatotoxicity could be due to increased oxidative stress which was not reversible upon withdrawal of treatment within the time course of investigation in male rats.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil

Adedara

Farombi

2012

Cell Biochemistry & Function

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“…Although Orisakwe et al (2000) have reported the analgesic effect of BLCO compared with that of aspirin and justified its folkloric use for pain of leg ulcer and foot rot, its nephrotoxicity based on alterations in serum electrolytes, urea, and creatinine and pathological changes in kidney biopsies have also been reported (Orisakwe et al,2004b). In addition, BLCO has been reported to be hematotoxic and caused a significant dose‐dependent increases in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels but significantly decreased alkaline phosphatase level compared with the controls (Orisakwe et al,2005). BLCO has been shown to induce alterations in the liver mitochondria DNA concentrations, cytoplasmic total hydrocarbon, and calcium concentrations in adult guinea pigs exposed by intraperitoneal injection for 2 days (Oruambo and Jones,2007).…”

Section: Introductionmentioning

confidence: 99%

Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil

Adedara

Teberen

Ebokaiwe

et al. 2011

Environmental Toxicology

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The local population of Niger-Delta in the Southern part of Nigeria have used bonny light crude oil (BLCO) as a remedy for various ailments and are exposed to some extent to this widespread environmental contaminant or its metabolites through the food chain. BLCO's hepatorenal toxicity was studied using oxidative stress indices to elucidate the precise nature and mechanism of action. BLCO was orally administered at concentrations of 0, 200, 400, and 800 mg kg⁻¹ to adult male rats for 7 days. After exposure, kidney weight was unaffected, but liver weight decreased significantly at 800 mg kg⁻¹ only compared with control. BLCO exposure resulted in dose-dependent elevation of serum aminotransferases, total bilirubin, urea, and creatinine. Activities of superoxide dismutase and catalase decreased significantly, whereas γ-glutamyltransferase activity and the level of glutathione increased significantly in BLCO-treated animals compared with control in both liver and kidney of rat. Renal activities of glucose-6-phosphatase and 5'-nucleotidase markedly decreased in a dose-dependent manner in BLCO-exposed rats. In addition, the levels of hydrogen peroxide and lipid peroxidation significantly increased, dose dependently, in liver and kidney of BLCO-treated rats compared with control. BLCO-treated rats showed marked degeneration of kidney evident in cortical hemorrhages, tubular necrosis, protein casts, and cellular infiltration. However, no treatment-related liver histopathology was observed. The results suggested that BLCO elicits disruption of antioxidant status and concomitant elevation of hydrogen peroxide and lipid peroxidation differentially in liver and kidney of rats. The hepatorenal toxicity of BLCO could be due to induction of oxidative stress in liver and kidney.

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“…The ingestion and absorption of this crude oil either orally or through consumption of polluted species or by skin contact represents pathways for delivery of potential toxicants in the crude oil into the system. Other investigations on BLCO have reported that it is hepatotoxic, hematotoxic and nephrotoxic (Orisakwe et al, 2004;Orisakwe et al, 2005;Igwe et al, 2008).…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 94%

Serum Heavy Metal Content of Albino Rats Exposed to Bonny Light Crude Oil.

F.U¹,

K.O²,

Ogunka-Nnoka³

2016

IJAR

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Hepatotoxic and haematological effects of Nigerian Bonny light crude oil in male albino rats

Cited by 16 publications

References 9 publications

Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil

Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil

Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil

Serum Heavy Metal Content of Albino Rats Exposed to Bonny Light Crude Oil.

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