Hepatotoxic and Neurotoxic Potential of Iron Oxide Nanoparticles in Wistar Rats: a Biochemical and Ultrastructural Study

Mabrouk, Mostafa; Fouad, Ghadha Ibrahim; El-Sayed, Sara A.M.; Rizk, Maha Z.; Beherei, Hanan H.

doi:10.1007/s12011-021-02943-4

Cited by 13 publications

(7 citation statements)

References 120 publications

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“…However, elevated AST and ALT activities were not associated with hepatotoxicity, as demonstrated by the histopathological investigation of the liver (Figure 11b-d). This elevated serum levels of transaminases might be demonstrated as a normal biological response against exposure to nanoparticles, as explained previously [58].…”

Section: Discussionsupporting

confidence: 67%

Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies

et al. 2022

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Magnesium silicate (MgS) nanopowders doped with barium oxide (BaO) were prepared by sol-gel technique, which were then implanted into a fracture of a tibia bone in rats for studying enhanced in vivo bone regeneration. The produced nanopowders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), scanning electron microscope with energy-dispersive X-ray spectrometry (SEM-EDX) and transmission electron microscope (TEM). Mechanical and bactericidal properties of the nanopowders were also determined. Increased crystallinity, particle diameter and surface area were found to decrease after the BaO doping without any notable alterations on their chemical integrities. Moreover, elevated mechanical and antibacterial characteristics were recognized for higher BaO doping concentrations. Our animal studies demonstrated that impressive new bone tissues were formed in the fractures while the prepared samples degraded, indicating that the osteogenesis and degradability of the BaO containing MgS samples were better than the control MgS. The results of the animal study indicated that the simultaneous bone formation on magnesium biomaterial silicate and barium MgS with completed bone healing after five weeks of implantations. The findings also demonstrated that the prepared samples with good biocompatibility and degradability could enhance vascularization and osteogenesis, and they have therapeutic potential to heal bone fractures.

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Section: Discussionsupporting

confidence: 67%

Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies

et al. 2022

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“…By adding CuO dopant, the isotherms demonstrated noticeable changes. According to International Union of Pure and Applied Chemistry (IUPAC) classification, the resulting isotherm curves for all samples show hysteresis behavior with two branches, adsorption, and desorption, demonstrating the presence of open pores between its particles 23,33 …”

Section: Resultsmentioning

confidence: 99%

Copper‐doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention

El‐Sayed,

ElShebiney,

Beherei

et al. 2024

J Biomed Mater Res

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Calvarial defects of bone present difficult clinical situations, and their restoration using biocompatible materials requires special treatments that enable bone regeneration. Magnesium phosphate (MgP) is known as an osteoinductive biomaterial because it contains Mg2+ ions and P ions that enhance the activity of osteoplast cells and help in bone regeneration. In this study, MgP and CuO‐doped MgP were fabricated and characterized for their physicomechanical properties, particle size, morphology, surface area, antibacterial test, and in vitro bioactivity evaluation using the following techniques: X‐rays diffraction, Fourier‐transformer infrared, TEM, and Brunauer, Emmett and Teller (BET) surface area, X‐rays photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM). Furthermore, these nanopowders were implanted in adult inbred male Wistar rats and studied after two periods (28 and 56 days). The results demonstrated that the obtained semiamorphous powders are in nanoscale (≤ 50 nm). XPS analysis ensured the preparation of MgP as mono MgP and CuO were incorporated in the structure as Cu2+. The bioactivity was supported by the observation of calcium phosphate layer on the nanopowders' surface. The in vivo study demonstrated success of MgP nanopowders especially those doped with CuO in restoration of calvarial defect bone. Therefore, fabricated biomaterials are of great potential in restoration of bone calvarial defects.

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“…IONPs-chloride, IONPs-lactate, and IONPs-nitrate (100 mg/kg) showed no obvious signs of toxicity in rats after oral administration for 14 days. Compared to IONPs@lactate and IONPs@nitrate, IONPs@chloride was the safest compound and induced less oxidative stress in rats [ 51 ]. IONPs functionalized with or without human albumin were both biocompatible in rats, which did not change the system hemodynamic or microcirculation.…”

Section: Applications Of Ionps In Animal Modelsmentioning

confidence: 99%

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng,

Shi,

Zhu

et al. 2024

J Nanobiotechnol

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The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable and low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs in clinical use at present. Some IONPs approved for clinical use have been withdrawn due to insufficient understanding of its biomedical applications. Therefore, a systematic summary of IONPs’ preparation and biomedical applications is crucial for the next step of entering clinical practice from experimental stage. This review summarized the existing research in the past decade on the biological interaction of IONPs with animal/cells models, and their clinical applications in human. This review aims to provide cutting-edge knowledge involved with IONPs’ biological effects in vivo and in vitro, and improve their smarter design and application in biomedical research and clinic trials. Graphical Abstract

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Hepatotoxic and Neurotoxic Potential of Iron Oxide Nanoparticles in Wistar Rats: a Biochemical and Ultrastructural Study

Cited by 13 publications

References 120 publications

Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies

Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies

Copper‐doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

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