Hepatotoxicity associated with first-line antitubercular drugs in children at a tertiary care facility

Aims: The study aims to synthesize bioactive hybrid pharmacophores (thiazole ring and imidazo[2,1-b]thiazole system) by incorporating them to one biological assessment molecular system. Background: Literature survey revealed that various imidazo[2,1-b]thiazoles, thiazoles and hydrazones have powerful anti-mycobacterial activity. Objective: This study demonstrates the effectiveness of molecular hybridization and the scope for imidazo[2,1-b]thiazole-hydrazone-thiazoles to develop as promising anti-mycobacterial agents. Method: Several imidazo[2,1-b]thiazole–hydrazine-thiazoles 5a-g, 7a,b, 9a,b, 11a,b, 13, and 15a,b were generated using a molecular hybridization strategy and assessed against Mycobacterium tuberculosis (ATCC 25618) for their in vitro antituberculous activity. Result: Derivative 7b (MIC = 0.98 μg/mL) has shown the most promising anti-mycobacterial activity among the series tested. Brief structure-activity relationship studies found that the thiazole of chlorophenyl or pyridine or coumarin had a significant relation with the anti-mycobacterial activity. Conclusion: Promising anti-mycobacterial activity of compound 7b compared with reference drug suggests that this compound may contribute as a lead compound in search of new potential anti-mycobacterial agents.

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Hepatotoxicity associated with first-line antitubercular drugs in children at a tertiary care facility

Cited by 3 publications

References 6 publications

Adverse drug reactions in children and adolescents on daily antitubercular regimen: An observational longitudinal study

Adverse drug reactions in children and adolescents on daily antitubercular regimen: An observational longitudinal study

An updated review of medicinal plants useful in the treatment of tuberculosis

Synthesis of New Thiazole Clubbed Imidazo[2,1-b]thiazole Hybrid as Antimycobacterial Agents

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