Hepatotoxicity due to atractylis gummifera-L

Georgiou, M.; Biol., D.; Sianidou, L.; Hatzis, Tassos; Papadatos, J.; Koutselinis, A.

doi:10.3109/15563658809038564

Cited by 61 publications

(31 citation statements)

References 5 publications

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“…About 200 cases have been reported since then [4,10], mainly by accidental substitutions or due to children chewing the sweet gum obtained from the latex of its subterranean parts. Although most poisoning cases occur in North Africa [10] they have also been reported among European countries: Greece [11]; Spain [12]; Italy [13]. If used internally it is extremely toxic, even at very low doses.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors of Atractylis gummifera L. poisoning, Morocco

Achour¹,

Rhalem²,

Elfakir³

et al. 2013

East Mediterr Health J

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In Morocco, acute Atractylis gummifera L. poisoning represents the leading cause of death by plant poisoning especially for children. All cases received in the Moroccan poison control centre from January 1981 to December 2009 (n = 467) were included in a retrospective study of the characteristics and risk factors of A. gummifera L. poisoning The most vulnerable age group was children (63.4% of cases). Most cases were due to accidental exposure (75.5%), but some were from therapeutic use (18.1%) or attempted abortion (7.4%). Patients presented with moderate poison severity signs (grade 2) in 22.3% of cases or severe signs (grade 3) in 21.0%. The mortality rate was 39.2%. The majority of deaths (81.1%) occurred in children aged < 15 years following accidental exposure. Multivariate logistic regression analysis revealed that risk factors for mortality were coma (OR = 20.5); hepatitis (OR = 52.7) and rural residence (OR = 7.26), while gastric decontamination was a protector factor (OR = 0.26). Medicine and Pharmacy of Fez, Fez, Morocco (Correspondence to S. Achour: achoursanae@gmail.com 1 Laboratory of Toxicology, University Hospital and Faculty of

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Section: Discussionmentioning

confidence: 99%

Prognostic factors of Atractylis gummifera L. poisoning, Morocco

Achour¹,

Rhalem²,

Elfakir³

et al. 2013

East Mediterr Health J

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“…This plant is a life-threatening poisoning where all plant parts are toxic (240). Moreover, A. gummifera has been associated with several cases of hepatotoxicity including hepato-renal injury (89), hepatic necrosis (91) and death (91,95). Moreover, two main constituents are responsible for A. gummifera toxicity, which are atractylosides and gummiferin.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, two main constituents are responsible for A. gummifera toxicity, which are atractylosides and gummiferin. The proposed mechanism of A. gummifera-induce hepatotoxicity could be due to mitochondrial toxicity via inhibition of oxidative phosphorylation and induction of oxidative stress (95,100). Callilepsis laureola or Impila is another dangerous herb (97).…”

Section: Discussionmentioning

confidence: 99%

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Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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“…One extracts from its small flowers a much appreciated perfume. [17] Henna grows naturally in tropical and subtropical regions of …”

Section: Lawsonia Inermismentioning

confidence: 99%

Risk of Intoxication the Plants More Used in Herbal Medicine in Morocco

Drissi¹

2017

WJPR

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ABSTRACTwhich not exceeding a rate of 1%. On the other hand, the Symptomatic distribution showed that the majority of the cases of poisonings were unknown (30%), followed by digestive signs (12%) and by thermal disorders (10%). Among these species, we haveselected the most used plants in herbal medicine in Morocco. The main plants that caused poisoning in Morocco in recent years, according to the APCM, there are Peganum harmala (50%), Nigella sativa (11%), Lawsonia inermis (7.5%), oleander (5.8%) Dysphania ambrosioides (5.1%). Twelve non-toxic plants can become toxic because they contain phytochemicals, such as Camellia sinensis (Green tea), Artemisia absinthium (Chiba) and Zingember officinale (Skingbir).

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Hepatotoxicity due to atractylis gummifera-L

Cited by 61 publications

References 5 publications

Prognostic factors of Atractylis gummifera L. poisoning, Morocco

Prognostic factors of Atractylis gummifera L. poisoning, Morocco

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Risk of Intoxication the Plants More Used in Herbal Medicine in Morocco

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