Hepatotoxicity of dinitro-O-cresol in rats (Rattus norvegicus)

Abstract

In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8th hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats

Two Consecutive Acute Coronary Syndrome Patients after Dinitro-Ortho-Cresol Exposure

“…The causes of pesticide poisoning are mostly insecticides, herbicides, and rodenticides. The fatalities caused by pesticides are often due to suicidal intentions (1). However, especially in the spring and summer time, the incidence of poisoning increases unwittingly or due to environmental reasons.…”