Hepatotoxicity Related to Paraquat and Diquat Absorption Through Intact Skin

Peiró, Ana M.; Zapater, Pedro; Alenda, Cristina; Ramírez, Ana; Gutiérrez, Ana; Pérez‐Mateo, Miguel; Such, José

doi:10.1007/s10620-005-9056-2

Cited by 21 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can modulate the expression and activation of cellular regulatory systems such as NF-κB, leading to the inhibition of iNOS expression. Although curcumin has been proposed as a putative agent to protect against the oxidative stress generated after PQ injury, (Peiro et al, 2007;Soudamini et al, 1992) our data with N27 cells do not support this hypothesis and suggest that the use of curcumin as a therapeutic agent in the case of neurodegenerative disorders must be reevaluated.…”

Section: Discussioncontrasting

confidence: 56%

Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species

et al. 2009

View full text Add to dashboard Cite

Curcumin, the active compound of the rhizome of Curcuma longa has anti-inflammatory, antioxidant and antiproliferative activities. This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. While curcumin has been identified as an activator of apopotosis in several cell lines, the mechanism by which it initiates apoptosis, however, remains poorly understood. We considered curcumin from the point of view of its ability to protect against oxidative stress, the latter being one factor strongly implicated in the development of Parkinson’s disease. Althougth the etiology of Parkinson’s disease remains unknown, epidemiological studies have linked exposure to pesticides such paraquat to an increased risk of developing the condition. Analysis of the neurotoxic properties of these pesticide compounds has been focused on their ability to induce oxidative stress in neural cells. Given curcumin’s capacity to protect against oxidative stress, it has been considered as a potential therapeutic agent for neurodegenerative diseases such as Parkinson’s disease that involve an oxidative stress component. In the present report we describe the effect of curcumin in paraquat-mediated apoptosis of N27 mesencepahlic cells. We show that subtoxic concentrations of curcumin sensitize N27 mesencephalic cells to paraquat-mediated apoptosis.

show abstract

Section: Discussioncontrasting

confidence: 56%

Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The general population of industrialized countries is exposed to pesticide residues mainly through the diet (Melnyk and others ). Moreover, accidental poisonings caused by these toxic compounds occur among children and farmers (Peiró and others ; Chen and others ).…”

Section: The Possibility Of Using a Melanocarpa Berries And Their Prmentioning

confidence: 99%

“…This compound is characterized by high toxicity to humans and animals related to its redox activity (Dou and others ). Exposure to this xenobiotic leads to liver (Peiró and others ) and lung damage (Chen and others ). Moreover, this compound has been recognized to contribute to the development of Parkinson's disease (Chen and others ).…”

Section: The Possibility Of Using a Melanocarpa Berries And Their Prmentioning

confidence: 99%

See 1 more Smart Citation

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

Borowska

Brzóska

2016

Comp Rev Food Sci Food Safe

114

155

View full text Add to dashboard Cite

Aronia melanocarpa berries (chokeberries) constitute a very rich source of numerous substances exerting a beneficial impact on health, including mainly polyphenols (proanthocyanidins, anthocyanins, flavonoids, and phenolic acids), possessing antioxidative, anti-inflammatory, antiviral, anticancer, antiatherosclerotic, hypotensive, antiplatelet, and antidiabetic properties. Thus, the consumption of products made from chokeberries is of vital importance for health maintenance and protection. Nowadays, due to the growing prevalence of noncommunicable diseases and ubiquitous human exposure to numerous man-made and naturally occurring toxic substances, some of which are dangerous even at low amounts, it is very important to look for effective means of health protection. An important role in this regard may be played by A. melanocarpa berries; however, up to now the attention of scientists, nutritionists, and health practitioners has been focused mainly on the effectiveness of chokeberry products in the prevention and treatment of noncommunicable diseases, while only little attention has been paid to the possibility of their use to counteract the adverse health effects of exposure to xenobiotics. That is why in this review article the main interest has been focused on the possibility of using chokeberries in the protection against unfavorable health effects caused by the action of substances to which humans may be exposed environmentally and/or occupationally. The available experimental data indicate that not only the fruit but also the leaves of A. melanocarpa and their products may be effective means for prevention and treatment of the effects of toxic action of some xenobiotics in humans; however, further studies on this subject are necessary.

show abstract

“…This non-selective, contact herbicide has been used to control many submerged and floating aquatic macrophytes which interferes with the photosynthetic process, releasing strong oxidizers that rapidly disrupt and inactivate cells and cellular functions (at present banned in many EU countries). Severe oral diquat intoxication has been associated with cerebral haemorrhages and severe acute renal failure (Peiró et al, 2007). Also quinoxaline herbicides (containing the pyrazine fragment) are very useful herbicides.…”

Section: Pyrazine Herbicidesmentioning

confidence: 99%