Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth, Elizabeta; Valore, Erika V.; Territo, Mary; Schiller, Gary J.; Lichtenstein, Alan; Ganz, Tomas

doi:10.1182/blood-2002-10-3235

Cited by 1,252 publications

(1,205 citation statements)

References 14 publications

Supporting

Mentioning

1,093

Contrasting

Unclassified

Order By: Relevance

“…Hepcidin expression is increased in obesity 25 and other chronic inflammatory states. 46 Increased circulating hepcidin may reduce both gastrointestinal iron absorption 26 and iron release from the reticuloendothelial system. 47 Although we did not measure hepcidin concentrations, measurements of CRP indicated inflammation was clearly increased with greater adiposity (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

et al. 2008

View full text Add to dashboard Cite

Background: Overweight is increasing in transition countries, while iron deficiency remains common. In industrialized countries, greater adiposity increases risk of iron deficiency. Higher hepcidin levels in obesity may reduce dietary iron absorption. Therefore, we investigated the association between body mass index (BMI) and iron absorption, iron status and the response to iron fortification in populations from three transition countries (Thailand, Morocco and India). Methods: In Thai women (n ¼ 92), we examined the relationship between BMI and iron absorption from a reference meal containing B4 mg of isotopically labeled fortification iron. We analyzed data from baseline (n ¼ 1688) and intervention (n ¼ 727) studies in children in Morocco and India to look for associations between BMI Z-scores and baseline hemoglobin, serum ferritin and transferrin receptor, whole blood zinc protoporphyrin and body iron stores, and changes in these measures after provision of iron. Results: In the Thai women, 20% were iron deficient and 22% were overweight. Independent of iron status, a higher BMI Z-score was associated with decreased iron absorption (P ¼ 0.030). In the Indian and Moroccan children, 42% were iron deficient and 6.3% were overweight. A higher BMI Z-score predicted poorer iron status at baseline (Po0.001) and less improvement in iron status during the interventions (Po0.001). Conclusions: Adiposity in young women predicts lower iron absorption, and pediatric adiposity predicts iron deficiency and a reduced response to iron fortification. These data suggest the current surge in overweight in transition countries may impair efforts to control iron deficiency in these target groups. Interactions of the 'double burden' of malnutrition during the nutrition transition may have adverse consequences.

show abstract

Section: Discussionmentioning

confidence: 99%

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Hepcidin is downregulated in hypoxia and may explain the increase in iron absorption under hypoxia and the increased iron release from reticuloendothelial cells. Chronic inflammatory models (turpentine injection) in mice result in a pattern similar to anemia of chronic disease [49], and increased urinary excretion of hepcidin is observed in humans with anemia of chronic disease [50]. These data have suggested that hepcidin is the regulator in anemia of chronic disease [51].…”

Section: Physiology Of Ironmentioning

confidence: 93%

Iron deficiency: A concise review

2005

View full text Add to dashboard Cite

Iron deficiency is a major worldwide health problem. There is recent evidence that the anemia is only the last manifestation of the syndrome and that symptoms occur before the anemia is manifest. Advances in outlining the physiology of iron deficiency have been made, gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for the intravenous administration have developed. This review will highlight the epidemiology, physiology, clinical presentation, and treatment options. Am.

show abstract

“…Kulaksiz et al [7] reported that hepcidin was produced as an intrinsic peptide in the epithelial cells of the tubule and collecting duct in mammalian kidney and may be released luminally into the urine. In a study on 46 patients with chronic renal failure, not yet on dialysis, serum hepcidin correlated with 51Cr-EDTA clearance (r ¼ À0.44; P ¼ 0.005), creatinine clearance, serum creatinine, b-trace protein and cystatin C [5]. However, the authors did not provide biochemical characteristics of the studied population, not even a mean serum creatinine.…”

Section: Introductionmentioning

confidence: 92%

Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis

Małyszko

Pawlak

et al. 2006

Am. J. Hematol.

View full text Add to dashboard Cite

Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anemia, hypoxia, or inflammation. Hepcidin could also act as an indicator of functional iron deficiency in these patients. Cross-sectional study was performed to assess hepcidin correlations with renal function, iron status, and hsCRP in patients with chronic renal failure on conservative treatment, on hemodialyses, and in kidney transplant recipients. Iron status, complete blood count, creatinine, albumin, lipids were assessed using standard laboratory methods. GFR was estimated using MDRD formula. Hepcidin and high sensitivity CRP were measured using commercially available kits. Ferritin and hepcidin were higher in hemodialyzed patients, kidney transplant recipients, and patients with chronic renal failure over controls. In patients with chronic renal failure, hepcidin correlated significantly with total protein, albumin, creatinine, and eGRF. In kidney transplant recipients, hepcidin correlated significantly in univariate analysis, with total protein, ferritin, time after transplantation, creatinine, eGRF and tended to correlate with cholesterol. In hemodialyzed patients hepcidin, correlated significantly with triglycerides, albumin, creatinine, urea, residual renal function, and hsCRP. In healthy volunteers, hepcidin was related to triglycerides and ferritin. Multiple regression analysis in hemodialyzed patients showed that hepcidin was independently related to creatinine, triglycerides, and residual renal function. Multiple regression analysis in kidney transplant recipients showed that hepcidin was independently related only to GFR and ferritin. Elevated hepcidin in all groups of patients studied may be due to low grade inflammation, frequently encountered in this population and mainly to impaired renal function. Am. J. Hematol. 81:832-837, 2006. V V C 2006 Wiley-Liss, Inc.

show abstract

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Cited by 1,252 publications

References 14 publications

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

Iron deficiency: A concise review

Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis

Contact Info

Product

Resources

About