Hepcidin decreases over the first year of life in healthy African infants

Mupfudze, Tatenda; Stoltzfus, Rebecca J.; Rukobo, Sandra; Moulton, Lawrence H.; Humphrey, Jean H.; Prendergast, Andrew J.

doi:10.1111/bjh.12567

Cited by 17 publications

(19 citation statements)

References 10 publications

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“…A similar decrease in hepcidin from the age of 6 wk to 1 y has been observed in term infants with no iron deficiency anemia (ferritin >12 μg/l and Hb >105 g/l at 3 and 6 mo and >100 g/l at 12 mo) (14). This decrease in hepcidin was accompanied by a similar decrease in concentrations of ferritin, and this previously described correlation between both biomarkers was not influenced by age.…”

Section: Articlessupporting

confidence: 84%

Serum hepcidin in infants born after 32 to 37 wk of gestational age

et al. 2015

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Background: Preterm infants are at risk of iron deficiency (ID). Hepcidin has been suggested as a good additional indicator of ID in preterm infants, next to ferritin. Methods: In a prospective observational study, we analyzed serum hepcidin in 111 infants born after 32+0 to 36+6 wk gestational age during the first 4 mo of life. results: Hepcidin concentrations decreased during the first 4 mo of life, and concentrations were lower in infants with ID compared to those without ID. Infants who developed ID at the age of 4 mo had already significantly lower levels of hepcidin at 1.5 mo of age, while ferritin was already significantly lower at the age of 1 wk. conclusion: Hepcidin concentrations of late preterm infants decrease during the first 4 mo of life. This decrease, which parallels a decrease of ferritin concentration, we interpret as a physiological response, aiming to increase iron availability. Hepcidin concentrations are lower in infants with ID compared with those without ID, with a notable change already observed at 1.5 mo of age. Hepcidin can be used as an early marker of ID, although an additive value of hepcidin over ferritin in the diagnosis of ID is not present.

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Section: Articlessupporting

confidence: 84%

Serum hepcidin in infants born after 32 to 37 wk of gestational age

et al. 2015

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“…These values can be used as for any other hepcidin assay worldwide that is standardized using the same secondary RM for calibration. 22 TA B L E 5 Results of linear regression models for hepcidin/ferritin ratio (pmol/µg) adjusted for age and time of blood sampling and stratified by sex 26.8%, with ß -0.057, CI -0.072 to -0.041 (P .000), ß 0.175, CI 0.023-0.326 (P .024), ß 0.432, CI 0.221-0.643 (P .000) for age, sampling time 12-3 PM and sampling time 3-6 PM, respectively. c For females, multivariate linear regression model with log-transformed hepcidin/ferritin ratio as the dependent variable and age (continuous variable) and sampling time as independent variables showed R 2 13.6%, with ß -0.042, CI -0.063 to -0.021 (P .000), ß 0.179, CI 0.026-0.384 (P .087), ß 0.250, CI -0.039-0.539 (P .089) for age, sampling time 12-3 PM and sampling time 3-6 PM, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Analyses were stratified by sex because of sex-specific differences in hepcidin levels and iron homeostasis that have been described earlier. 20,26,27,30,38,39 SPSS version 22 was used for data analysis.…”

Section: Males Femalesmentioning

confidence: 99%

“…The wide reference ranges reflect the substantial interindividual variation in serum hepcidin concentrations. Because of the earlier described sex-specific differences in both adults and children 20,26,27,30,39 regarding serum hepcidin levels, all analyses were stratified for sex. As shown in Table 2 and Table S2, we did not observe a difference in serum hepcidin levels between males and females.…”

Section: Age-and Sex-specific Reference Ranges For Serum Hepcidin Conmentioning

confidence: 99%

“…20 Implementation of measurement of serum hepcidin levels in clinical pediatrics is hampered by the lack of standardized reference values for healthy children from different age groups, relative to iron status. [24][25][26] Available studies concern either small series with limited age groups or series including children with (anemia of) inflammation. 16,[27][28][29][30][31] As a first step to the implementation of serum hepcidin measurements in pediatric clinical practice, we established age-and sex-specific (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Standardized serum hepcidin values in Dutch children: Set point relative to body iron changes during childhood

Donker

Galesloot²,

Laarakkers

et al. 2019

Pediatric Blood & Cancer

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Background: Use of serum hepcidin measurements in pediatrics would benefit from standardized age-and sex-specific reference ranges in children, in order to enable the establishment of clinical decision limits that are universally applicable. Procedure:We measured serum hepcidin-25 levels in 266 healthy Dutch children aged 0.3-17 years, using an isotope dilution mass spectrometry assay, standardized with our commutable secondary reference material (RM), assigned by a candidate primary RM. Results:We constructed age-and sex-specific values for serum hepcidin and its ratio with ferritin and transferrin saturation (TSAT). Serum hepcidin levels and hepcidin/ferritin and TSAT/hepcidin ratios were similar for both sexes. Serum hepcidin and hepcidin/ferritin ratio substantially declined after the age of 12 years and TSAT/hepcidin ratio gradually increased with increasing age. Serum hepcidin values for Dutch children <12 years (n = 170) and >12 years (n = 96) were 1.9 nmol/L (median); 0.1-13.1 nmol/L (p2.5-p97.5) and 0.9 nmol/L; 0.0-9.1 nmol/L, respectively. Serum ferritin was the most significant correlate of serum hepcidin in our study population, explaining 15.1% and 7.9% of variance in males and females, respectively. Multivariable linear regression analysis including age, blood sampling time, iron parameters, ALT, CRP, and body mass index as independent variables showed a statistically significant negative association between age as a dichotomous variable (≤12 vs >12 years) and log-transformed serum hepcidin levels in both sexes. Conclusions:We demonstrate that serum hepcidin relative to indicators of body iron is age dependent in children, suggesting that the set point of serum hepcidin relative to stored and circulating iron changes during childhood. K E Y W O R D Schild, ferritin, hepcidin, pediatric reference ranges, transferrin saturation

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Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants

Aranda

Bedmar²,

Arija

et al. 2018

Ann Hematol

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The aims of this study were to describe hepcidin levels and to assess their associations with iron status and the main variants in the HFE gene in healthy and full-term newborns during the first year of life, as a longitudinal study conducted on 140 infants. Anthropometric and biochemical parameters, hepcidin, hemoglobin (Hb), serum ferritin (SF), transferrin saturation (TS), mean corpuscular volume (MCV), and C-reactive protein (CRP), were assessed in 6- and 12-month-olds. Infants were genotyped for the three main HFE variants: C282Y, H63D, and S65C. Hepcidin levels increased from 6 to 12 months of age (43.7 ± 1.5 to 52.0 ± 1.5 ng/mL; p < 0.001), showing higher levels in infants with better iron status compared to those with iron deficiency (ID) (44.8 ± 1.5 vs 37.9 ± 1.3 ng/mL, p < 0.018, and 54.3 ± 1.5 vs 44.0 ± 1.4 ng/mL, p < 0.038, in 6- and 12-month-olds, respectively). In multivariate linear regression models, iron status was found to be associated with hepcidin levels in infants with wild-type HFE gene (p = 0.046 and p = 0.048 in 6- and 12-month-olds, respectively). However, this association was not found in HFE-alteration-carrying infants. Hepcidin levels increased in healthy infants during the first year of life and were positively associated with iron levels only in infants with wild-type HFE gene, a situation that requires further investigation.

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Hepcidin decreases over the first year of life in healthy African infants

Cited by 17 publications

References 10 publications

Serum hepcidin in infants born after 32 to 37 wk of gestational age

Serum hepcidin in infants born after 32 to 37 wk of gestational age

Standardized serum hepcidin values in Dutch children: Set point relative to body iron changes during childhood

Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants

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