Hepcidin in Children and Adults with Acute Leukemia or Undergoing Hematopoietic Cell Transplantation: A Systematic Review

Słomka, Artur; Łęcka, Monika; Styczyński, Jan

doi:10.3390/cancers14194936

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…Elevated serum hepcidin level in combination with Hb-for-age Z-score were found to be predictive for Kawasaki disease [30]. In patients with acute leukemia or undergoing hematopoietic cell transplantation who frequently received red blood cell concentrate transfusions, serum ferritin and hepcidin levels were upregulated at the same time by systemic iron overload [31]. Furthermore, higher levels of serum hepcidin level was noted in obese children and adolescents, which may suggest a low-grade inflammatory state and may reflect in increased iron content in these patient groups [32].…”

Section: Discussionmentioning

confidence: 99%

Elevated Urinary Hepcidin Level and Hypoferremia in Infants with Febrile Urinary Tract Infection: A Prospective Cohort Study

Hsu

Tang

Su³

et al. 2023

Children

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To evaluate the kinetics of serum and urinary hepcidin levels along with anemia-related parameters during the infection course of infants with febrile urinary tract infection (UTI), we enrolled febrile infants aged one to four months in this prospective study. Febrile patients with UTI were allocated into Escherichia coli (E. coli) or non-E. coli groups according to urine culture results. Septic workup, blood hepcidin, iron profile, urinalysis, and urinary hepcidin–creatinine ratio were collected upon admission and 3 days after antibiotic treatment. In total, 118 infants were included. On admission, the febrile UTI group showed a significant reduction in serum iron level and a significant elevation of urinary hepcidin–creatinine ratio compared to the febrile control counterpart. Moreover, urinary hepcidin–creatinine ratio had the highest odds ratio, 2.01, in logistics regression analysis. After 3 days of antibiotic treatment, hemoglobin and the urinary hepcidin–creatinine ratio were significantly decreased. Patients with an E. coli UTI had a significantly decreased urinary hepcidin–creatinine ratio after 3 days of antibiotics treatment, whereas the non-E. coli group showed insignificant changes. Our study suggested that the urinary hepcidin–creatinine ratio elevated during acute febrile urinary tract infection and significantly decreased after 3 days of antibiotics treatment, especially in E. coli UTI.

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Section: Discussionmentioning

confidence: 99%

Elevated Urinary Hepcidin Level and Hypoferremia in Infants with Febrile Urinary Tract Infection: A Prospective Cohort Study

Hsu

Tang

Su³

et al. 2023

Children

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“…In these studies, the number of patients with MDS did not constitute the majority [37][38][39][40]. The inclusion of such manuscripts may pose a challenge when drawing valid conclusions; the papers referenced were the focus of our prior systematic review [32].…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…In a previous publication, we explored the role of hepcidin in acute leukemias [32]. However, as far as we are aware, there is still no systematic review that completely addresses the role of hepcidin in MDS.…”

Section: Introductionmentioning

confidence: 99%

The Role of Hepcidin in Myelodysplastic Syndromes (MDS): A Systematic Review of Observational Studies

Słomka,

Pokrzywa,

Strzała

et al. 2024

Cancers

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Iron overload emerges as a serious complication in myelodysplastic syndromes (MDS), particularly associated with frequent transfusions during the course of the disease. The discovery and description of hepcidin’s mechanisms of action have contributed to a deeper understanding of iron metabolism. The existing literature reports a potential role of hepcidin in MDS, yet these data are fragmented and presented in an unstructured, somewhat chaotic manner. Hence, to address the existing data, we performed a systematic review of observational studies examining hepcidin levels in MDS. An extensive review of three bibliographic databases (Pubmed, Web of Science, and Scopus) enabled us to identify 12 observational studies. These studies focused primarily on adult patients with low-risk MDS who underwent transfusions and chelation therapy. An in-depth analysis of these manuscripts led to four main conclusions: (1) although high serum hepcidin levels are associated with MDS, most studies generally have not found a significant difference in these levels between patients and healthy individuals; (2) serum hepcidin levels are specific to MDS type; (3) serum hepcidin levels in MDS are strongly associated with transfusions and the genetic status of patients; and (4) high-risk MDS is associated with high serum hepcidin levels. While we have furnished a comprehensive summary of the significance of hepcidin in MDS, there are still gaps that future research should address. This pertains primarily to the capacity of hepcidin in predicting adverse outcomes for MDS patients and evaluating the efficacy of chelation therapy or the need for transfusion.

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“…Hepcidin is crucial in this mechanism [8]. Interleukin 6 (IL-6) is involved in the regulation of serum iron levels via the control of ferroportin 1 which is an iron transporter.…”

Section: Introductionmentioning

confidence: 99%

Effect of iron deficiency anemia on blood levels of interleukin 6 and infection rates in children: a pilot study

et al. 2023

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Introduction: Iron deficiency is the most common micronutrient deficiency worldwide. Iron activates the growth and differentiation of immune cells and cytokine actions. Interleukin 6 is a pro-inflammatory cytokine that stimulates the differentiation of B lymphocytes into plasma cells and activates T lymphocytes. Our study aimed to evaluate the correlation between blood levels of iron and interleukin 6 (IL-6) and its impact on infection rates in children. Materials and methods:The study included 36 children. The serum concentration of IL-6, iron, and morphology parameters from a venous blood sample were assessed. An anonymous survey of children's parents was conducted regarding the frequency of infections before and after the diagnosis of anemia.Results: In the study group, the levels of IL-6 were higher than in the control group and showed greater variability between individual patients. There was a statistically significant, negative correlation between IL-6 and iron levels within the study group (p = 0.012), and a decrease in the number of viral diarrheas after the diagnosis of anemia compared to the state before diagnosis (p = 0.041). There was no statistically significant change in the number of colds or the mean duration of infection (p = 0.144, p = 0.498), nor in the incidence of other infectious diseases and antibiotics intake in the study group before and after iron deficiency anemia diagnosis (p = 0.500, p = 0.219).Conclusions: IL-6 might play a role in iron deficiency anemia. Increased levels of IL-6 were shown not to correspond with visible changes in rates and the course of colds, but did result in a reduction in the frequency of viral diarrhea. Further research on a larger group of carefully selected patients is required to determine the effect of anemia on the immune system.

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Hepcidin in Children and Adults with Acute Leukemia or Undergoing Hematopoietic Cell Transplantation: A Systematic Review

Cited by 8 publications

References 45 publications

Elevated Urinary Hepcidin Level and Hypoferremia in Infants with Febrile Urinary Tract Infection: A Prospective Cohort Study

Elevated Urinary Hepcidin Level and Hypoferremia in Infants with Febrile Urinary Tract Infection: A Prospective Cohort Study

The Role of Hepcidin in Myelodysplastic Syndromes (MDS): A Systematic Review of Observational Studies

Effect of iron deficiency anemia on blood levels of interleukin 6 and infection rates in children: a pilot study

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