Heptachlor epoxide: Effects on calcium-mediated transmitter release from brain synaptosomes in rat

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

“… Insecticide Moser et al [ 259 ]: perinatal exposure produced neurochemical and persistent neurobehavioral changes, including alterations in spatial learning and memory. 95 Heptachlor epoxide Organo-chlorinei Kirby et al [ 260 ]: toxic effects of heptachlor epoxide may be responsible for loss of maximal dopamine uptake Insecticide Metabolite Yamaguchi et al [ 261 ]: effects on calcium mediated transmitter release from brain synaptosomes of rats. 96 Hexachlorobutadiene Solvent Badaeva et al [ 262 , 263 ]: neurotoxic effects in the postnatal period of ontogeny in the rats.…”

The Role of Cell Calcium in Current Approaches to Toxicology

“…Other organochorine insecticides, including heptachlor and lindane, which is a structural analog of inositol, have been shown to alter Ca2' homeostasis. The changes in nerve terminal [Ca2"]i may be responsible for the neurotoxic action of these pesticides (21)(22)(23)(24).…”

Mode of Inhibition of Chitin Synthesis by Diflubenzuron in the Cabbage Armyworm, <i>Mamestra brassicae</i> L.

“…The reaction was initiated by the addition of 100al 32P-ATP (final concentration 0.25 mm). After incubation at 30C for 20 min, the liberated 32P was measured following the method of Yamaguchi et al 19 For the Na+-K+ ATPase activity of midguts excised from the insects treated with diflubenzuron, newly molted final instar larvae were fed on the artificial diet containing 10 ppm diflubenzuron and the normal diet as a control, and sacrificed 24 hr after feeding was started.…”

“…Ca2+ ATPase activity was measured following the method of Yamaguchi et al 19 Preparation of enzyme source was the same as the above except for the sodium iodide treatment. The resulting pellets were suspended in 5 ml buffer C which consisted of 5 mm MgCl2, 100mm KCl, 1mm EGTA in 10mm Tris-HC1 (pH 7.5).…”