Heptadentate chelates for <sup>89</sup>Zr-radiolabelling of monoclonal antibodies

Guillou, Amaury; Ouadi, Ali; Holland, Jason P.

doi:10.1039/d2qi00442a

Inorg. Chem. Front.

2022

DOI: 10.1039/d2qi00442a

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Heptadentate chelates for ⁸⁹Zr-radiolabelling of monoclonal antibodies

Amaury Guillou

Ali Ouadi

Jason P. Holland

Abstract: Zirconium complexation chemistry is an important area of research in the context of developing radiolabelled proteins for applications in diagnostic positron emission tomography (PET) imaging. Herein, we report the synthesis...

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Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Lin,

Lechermann,

Huestis

et al. 2024

Angewandte Chemie

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This review discusses recent advances in light‐driven radiochemistry for three key isotopes: fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission tomography (PET). In the case of fluorine‐18, the predominant approach involves the use of cyclotron‐produced [18F]fluoride or reagents derived thereof. Light serves to activate either the substrate or the fluorine‐18 labeled reagent. Advancements in carbon‐11 photomediated radiochemistry have been leveraged for the radiolabeling of small molecules, achieving various transformations, including 11C‐methylation, 11C‐carboxylation, 11C‐carbonylation, and 11C‐cyanation. Contrastingly, zirconium‐89 photomediated radiochemistry differs from fluorine‐18 and carbon‐11 approaches. In these cases, light facilitates a postlabeling click reaction, which has proven valuable for the labeling of large biomolecules such as monoclonal antibodies. New technological developments, such as the incorporation of photoreactors in commercial radiosynthesizers, illustrate the commitment the field is making in embracing photochemistry. Taken together, these advances in photomediated radiochemistry enable radiochemists to apply new retrosynthetic strategies in accessing novel PET radiotracers.

show abstract

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Lin,

Lechermann,

Huestis

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Lin,

Lechermann,

Huestis

et al. 2024

Angew Chem Int Ed

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Evaluation of coumarin-tagged deferoxamine as a Zr(IV)-based PET/fluorescence dual imaging probe

Romano,

Zizi,

Salvatore

et al. 2023

Journal of Inorganic Biochemistry

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Heptadentate chelates for ⁸⁹Zr-radiolabelling of monoclonal antibodies

Abstract: Zirconium complexation chemistry is an important area of research in the context of developing radiolabelled proteins for applications in diagnostic positron emission tomography (PET) imaging. Herein, we report the synthesis...

Cited by 4 publications

References 42 publications

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Evaluation of coumarin-tagged deferoxamine as a Zr(IV)-based PET/fluorescence dual imaging probe

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Heptadentate chelates for 89Zr-radiolabelling of monoclonal antibodies

Abstract: Zirconium complexation chemistry is an important area of research in the context of developing radiolabelled proteins for applications in diagnostic positron emission tomography (PET) imaging. Herein, we report the synthesis...

Cited by 4 publications

References 42 publications

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Evaluation of coumarin-tagged deferoxamine as a Zr(IV)-based PET/fluorescence dual imaging probe

Contact Info

Product

Resources

About

Heptadentate chelates for ⁸⁹Zr-radiolabelling of monoclonal antibodies