HER-2, EGFR, Cox-2 and Ki67 expression in lymph node metastasis of canine mammary carcinomas: Association with clinical-pathological parameters and overall survival

Araújo, Marina Rios de; Campos, Leonardo; Damasceno, Karine Araújo; Gamba, Conrado de Oliveira; Ferreira, Ênio; Cassali, Geovanni Dantas

doi:10.1016/j.rvsc.2016.03.020

Cited by 40 publications

(44 citation statements)

References 49 publications

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“…Previous studies have reported a lower survival rate in animals presenting regional lymph node metastases (stage IV) compared to animals without lymph node involvement (Araujo et al, 2016), and worse prognoses were associated with distant metastases (stage V) compared to stages I- IV (Yamagami et al, 1996;Karayannopoulou Arq. Bras.…”

Section: Discussionmentioning

confidence: 97%

Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms

Nunes

Campos

Teixeira

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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Canine mammary neoplasms (CMNs) are the most frequent lesions and in female dogs. However, studies correlating pathological criteria with clinical evolution in female dogs with mammary neoplasms are scarce. The present study aims to present epidemiological, clinical-pathological and overall survival data to help establish the prognosis and understand the biological behavior of CMNs. A total of 1539 cases were included (85% malignant and 13% benign). Tumor size was an important prognostic factor and was associated with overall patient survival (P< 0.0001). Most dogs diagnosed with malignant neoplasms (83%) had initial clinical staging, although 17% had regional or distant metastases at the time of diagnosis and lower overall survival (P< 0.0001). Carcinoma in mixed tumor was the most frequent histological type and had a better prognosis. Solid carcinomas, micropapillary carcinomas and carcinosarcomas were considered histological types with aggressive biological behavior and were associated with a worse prognosis and lower overall survival (P< 0.0001).

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Section: Discussionmentioning

confidence: 97%

Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms

Nunes

Campos

Teixeira

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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“…There was, however, a relative uncertainty of predictability of this spontaneous cancer as a translational model, as the natural history and prognostic factors have been described in relatively small cohorts [ 19 – 25 , 27 – 41 ]. The present study is of particular interest because (1) mammary carcinomas in situ have been carefully excluded from analysis, using p63 immunohistochemistry when necessary, which is rarely, if ever, performed in veterinary studies, but of paramount importance in human breast oncology; (2) the cases were reviewed blindly by veterinary and medical pathologists, until consensus diagnoses were achieved, which permitted interpretation of canine samples using the criteria used for human breast cancer; (3) this is the largest cohort of CMCs described so far, which allowed for multivariate survival analyses with sufficient statistical power; (4) this study is one of the rare reports [ 14 , 15 , 17 , 30 , 37 ] of locoregional recurrence, distant metastasis-free interval, and specific survival in dogs with CMCs, as most previous studies focused on disease-free survival and overall survival only [ 18 – 21 , 23 – 25 , 28 , 29 , 31 , 32 , 35 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Nguyen

Peña

Ibisch

et al. 2017

Breast Cancer Res Treat

111

128

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Purpose Dogs have been proposed as spontaneous animal models of human breast cancer, based on clinicopathologic similarities between canine and human mammary carcinomas. We hypothesized that a better knowledge of the natural history and prognostic factors of canine invasive mammary carcinomas would favor the design of preclinical trials using dogs as models of breast cancer. Methods The 2-year outcome of 350 female dogs with spontaneous invasive mammary carcinoma was studied. The investigated prognostic factors included age at diagnosis,

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“…In our cohort, no HER2-overexpressing tumors as defined by a 3+ immunohistochemical score were observed. Previous studies dealing with canine mammary tumors have, however, reported significant levels of HER2 expression in CMC without any agreement on its prognostic value [ 27 , 49 , 50 ]. Nevertheless, the existence of HER2-overexpressing mammary tumors in dogs has to be considered as doubtful for methodological reasons (selection of antibodies, dilution, scoring criteria, and absence of appropriate controls).…”

Section: Discussionmentioning

confidence: 99%

Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance

Abadie

Nguyen

Loussouarn

et al. 2017

Breast Cancer Res Treat

102

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PurposeRelevant animal models of human breast cancer are currently needed, especially for the aggressive triple-negative breast cancer subtype. Recent studies and our results (Part 1) indicate that spontaneous canine invasive mammary carcinomas (CMCs) resemble human breast cancer by clinics and pathology as well as behavior and prognostic indicators. We hypothesized that the current molecular classifications of human breast cancer, used for therapeutic decision, could be relevant to dogs.MethodsThree hundred and fifty female dogs with spontaneous CMC and a 2-year follow-up were retrospectively included. By immunohistochemistry, CMCs were classified according to Nielsen (Clin Cancer Res 10:5367–5374, 2004) and Blows (PlosOne doi: 10.1371/journal.pmed.1000279, 2010) into the subtypes of human breast cancer.ResultsFour immunophenotypes were defined either according to Nielsen classification (luminal A 14.3%, luminal B 9.4%, triple-negative basal-like 58.6%, and triple-negative nonbasal-like 17.7% CMCs); or to Blows classification (luminal 1−: 11.4%, luminal 1+: 12.3%, Core basal phenotype: 58.6%, and five-negative phenotype: 17.7%). No HER2-overexpressing CMC as defined by a 3 + immunohistochemical score was observed in our cohort. By univariate and multivariate analyses, both immunophenotypical classifications applied to CMCs showed strong prognostic significance: luminal A or luminal 1+ CMCs showed a significantly longer disease-free interval (HR = 0.46), Overall (HR = 0.47), and Specific Survival (HR = 0.56) compared to triple-negative carcinomas, after adjustment for stage.ConclusionsIn our cohort, triple-negative CMCs largely predominated (76%), were much more prevalent than in human beings, and showed an aggressive natural behavior after mastectomy. Dogs are thus potent valuable spontaneous models to test new therapeutic strategies for this particular subtype of breast cancer.

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HER-2, EGFR, Cox-2 and Ki67 expression in lymph node metastasis of canine mammary carcinomas: Association with clinical-pathological parameters and overall survival

Cited by 40 publications

References 49 publications

Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms

Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms

Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance

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