HER2 expression and gene amplification in pT2a Gleason score 6 prostate cancer incidentally detected in cystoprostatectomies: comparison with clinically detected androgen-dependent and androgen-independent cancer

Overexpression of HER-2/neu in Patients with Prostatic Adenocarcinoma

“…This receptor is involved in various biological processes such as cell proliferation, differentiation, migration, and apoptosis. There is low expression of HER-2 in normal epithelial cells, including prostate epithelial cells (Montironi et al, 2006;Ali Nahit Sendur et al, 2012;Carrion et al, 2012).…”

Is There a Role for Prostate Tumour Overexpressed-1 in the Diagnosis of HGPIN and of Prostatic Adenocarcinoma? A Comparison with α-Methylacyl CoA Racemase

“…Some differences in marker expression between CyPs and RPs were observed. Such an observation suggested that there are differences in the field effects in terms of carcinogenesis between the two types of specimens (9)(10)(11)(12)(13)(14)(15).…”

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

“…There is a suggestion that HER-2 may have a role in prostate cancer development, however its expression is variable, ranging between 0 to 100% depending on the HER-2 assay used (Ratan et al, 2003) and gene amplification of the HER-2 gene ranges from 0 to 53% (Liu et al, 2001;Montironi et al, 2006). Despite this discrepancy, there is still a consistent association between HER-2 over expression and a higher risk tumor recurrence and death in men with prostate cancer according to a meta-analysis (Neto et al, 2010).…”