Herb drug interaction of Tinospora cordifolia (Willd.) Miers extract and Glimepiride: In vivo and in silico studies

Thomas, Asha; Shaikh, Aaftab S.; Raje, Amol A.; Lokhande, Kiran Bharat; Swamy, K. Venkateswara; Nagore, Dheeraj; Doke, Rohit R

doi:10.5958/0975-6892.2020.00068.4

Cited by 1 publication

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“…Consequently, it was found that Vd and CL for glimepiride were lowered. This alteration in PK parameters may be due to the inhibitory potential of berberine and other alkaloids present in Tinospora cordifolia extract on the activity of CYP2C9 (Thomas et al, 2020). Vora et al reported that the Tinospora cordifolia aqueous extract (400 mg/kg, p.o.)…”

Section: Introductionmentioning

confidence: 99%

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Thikekar

Thomas

Chitlange

2021

Phytotherapy Research

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Global diabetes epidemic is the major cause of fatality and lethality. As per IDF 2019 report, diabetes caused 4.2 million deaths, approximately 463 million people are living with diabetes and by 2045, this will rise to 700 million. Nowadays, the physicians and common people in both developed and developing countries are using medicinal plants and their formulations to treat diseases with the postulation that organic commodities are safe for consumption. These plants may act as inhibitors or inducers of the Cytochrome P450 or transport and efflux proteins or both and may alter gastrointestinal, renal functions leading to Herb‐Drug Interactions. This review intends to focus on the frequently employed medicinal plants, their traditional uses, their Cytochrome P450 inhibition or induction activity, phytochemical, and pharmacological effects, established HDI with the help of in vitro tools, in vivo pharmacokinetics and pharmacodynamics studies to understand the impact of herbs on ADME of the drug and whether it is beneficial, harmful or has no effect respectively. This review will help the physicians and other health care professionals as a reference guide to update their knowledge and expertise about HDI. However, more quality research in this area is needed to evaluate the efficacy of many herbal medicines, thereby reducing side effects and improving the safety of patients.

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Section: Introductionmentioning

confidence: 99%