Herb–drug interactions: a mechanistic approach

Sharma, Ajay Kumar; Kapoor, Vijay K.; Kaur, Gurjot

doi:10.1080/01480545.2020.1738454

Cited by 14 publications

(3 citation statements)

References 89 publications

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“…P450 is a cytochrome with an essential role in metabolism, being susceptible to induction or inhibition caused by substances found in plants [47,[69][70][71][72] with consequent repercussions on the expected effects of drugs.…”

Section: Plant/diet-drug Interactionsmentioning

confidence: 99%

Use of Medicinal Plants: Interindividual Variability of Their Effects from a Genetic and Anthropological Perspective

Pereira da Silva Oliveira,

do Céu Costa,

Pires Bicho

2024

Medicinal Plants - Chemical, Biochemical, and Pharmacological Approaches

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The use of plants for nutritional and therapeutic purposes has been constant over the centuries. The variability of enzymatic activity between individuals and populations in an attempt to adapt has been a conditioning mechanism, reflected in the incidence and prevalence of certain diseases, possible adverse effects of plant-derived nutrients and their interaction with medications, in addition to interference in natural selection and consequent geographical distribution of specific genetic polymorphisms in harmony with indigenous medicinal plants. The metabolizer type may influence the anticancer protective effect of certain plant-derived constituents, with interindividual variability to be considered. This chapter will deepen and develop the role of using plants in different geographic areas and populations over the centuries in producing the genetic variability of the metabolism of plant constituents in the context of environmental adaptation and ecogenetics. Possible therapeutic/adverse effects due to this variability will be discussed.

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Section: Plant/diet-drug Interactionsmentioning

confidence: 99%

Use of Medicinal Plants: Interindividual Variability of Their Effects from a Genetic and Anthropological Perspective

Pereira da Silva Oliveira,

do Céu Costa,

Pires Bicho

2024

Medicinal Plants - Chemical, Biochemical, and Pharmacological Approaches

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“…These several viral variants of COVID-19 spread simultaneously around the world, but most clinical trials with curcumin applications in COVID-19 treatment did not easily establish the sample criteria for the patient’s viral mutants. There some pieces of evidence show that curcumin has a significant inhibitory effect on cytochrome P450 (CYP450) enzymes ( Mashayekhi-Sardoo et al, 2021 ; Sharma et al, 2022 ), which play important roles in the phase 1 metabolism of several clinical drugs, such as steroids ( Zhao N. et al, 2021 ). Generally, steroids are widely used for anti-inflammation in the clinical treatment of COVID-19 ( Lin et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

Fu¹,

Kang³

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a positive-strand RNA virus, and has rapidly spread worldwide as a pandemic. The vaccines, repurposed drugs, and specific treatments have led to a surge of novel therapies and guidelines nowadays; however, the epidemic of COVID-19 is not yet fully combated and is still in a vital crisis. In repositioning drugs, natural products are gaining attention because of the large therapeutic window and potent antiviral, immunomodulatory, anti-inflammatory, and antioxidant properties. Of note, the predominant curcumoid extracted from turmeric (Curcuma longa L.) including phenolic curcumin influences multiple signaling pathways and has demonstrated to possess anti-inflammatory, antioxidant, antimicrobial, hypoglycemic, wound healing, chemopreventive, chemosensitizing, and radiosensitizing spectrums. In this review, all pieces of current information related to curcumin-used for the treatment and prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through in vitro, in vivo, and in silico studies, clinical trials, and new formulation designs are retrieved to re-evaluate the applications based on the pharmaceutical efficacy of clinical therapy and to provide deep insights into knowledge and strategy about the curcumin’s role as an immune booster, inflammatory modulator, and therapeutic agent against COVID-19. Moreover, this study will also afford a favorable application or approach with evidence based on the drug discovery and development, pharmacology, functional foods, and nutraceuticals for effectively fighting the COVID-19 pandemic.

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“…Simultaneous administration of herbs and drugs has the potential to imitate, magnify, or oppose each of their individual pharmacological effects [ 1 ]. While herbs show promise as therapeutically effective medicines, it is generally believed that further research is needed to validate their effectiveness when given along with conventional medications.…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats

Asdaq¹,

Challa²,

Alamri

et al. 2021

Molecules

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This study was conducted to determine the potential interaction of aged garlic extract (AGE) with carvedilol (CAR), as well as to investigate the role of S-allyl-l-cysteine (SAC), an active constituent of AGE, in rats with isoproterenol (ISO)-induced myocardial dysfunction. At the end of three weeks of treatment with AGE (2 and 5 mL/kg) or SAC (13.1 and 32.76 mg/kg), either alone or along with CAR (10 mg/kg) in the respective groups of animals, ISO was administered subcutaneously to induce myocardial damage. Myocardial infarction (MI) diagnostic predictor enzymes, lactate dehydrogenase (LDH) and creatinine kinase (CK-MB), were measured in both serum and heart tissue homogenates (HTH). Superoxide dismutase (SOD), catalase, and thiobarbituric acid reactive species (TBARS) were estimated in HTH. When compared with other groups, the combined therapy of high doses of AGE and SAC given alone or together with CAR caused a significant decrease in serum LDH and CK-MB activities. Further, significant rise in the LDH and CK-MB activities in HTH was noticed in the combined groups of AGE and SAC with CAR. It was also observed that both doses of AGE and SAC significantly increased endogenous antioxidants in HTH. Furthermore, histopathological observations corroborated the biochemical findings. The cytoprotective potential of SAC and AGE were dose-dependent, and SAC was more potent than AGE. The protection offered by aged garlic may be attributed to SAC. Overall, the results indicated that a high dose of AGE and its constituent SAC, when combined with carvedilol, has a synergistic effect in preventing morphological and physiological changes in the myocardium during ISO-induced myocardial damage.

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Herb–drug interactions: a mechanistic approach

Cited by 14 publications

References 89 publications

Use of Medicinal Plants: Interindividual Variability of Their Effects from a Genetic and Anthropological Perspective

Use of Medicinal Plants: Interindividual Variability of Their Effects from a Genetic and Anthropological Perspective

Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats

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